Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Samantha L Bell"'
Autor:
Huntly M Morrison, Julia Craft, Rafael Rivera-Lugo, Jeffery R Johnson, Guillaume R Golovkine, Samantha L Bell, Claire E Dodd, Erik Van Dis, Wandy L Beatty, Shally R Margolis, Teresa Repasy, Isaac Shaker, Angus Y Lee, Russell E Vance, Sarah A Stanley, Robert O Watson, Nevan J Krogan, Daniel A Portnoy, Bennett H Penn, Jeffery S Cox
Publikováno v:
PLoS Pathogens, Vol 19, Iss 6, p e1011088 (2023)
Macrophages employ an array of pattern recognition receptors to detect and eliminate intracellular pathogens that access the cytosol. The cytosolic carbohydrate sensors Galectin-3, -8, and -9 (Gal-3, Gal-8, and Gal-9) recognize damaged pathogen-conta
Externí odkaz:
https://doaj.org/article/bb529b2bbf75461d932dc89cb0aeb02a
Autor:
Krystal J Vail, Bibiana Petri da Silveira, Samantha L Bell, Noah D Cohen, Angela I Bordin, Kristin L Patrick, Robert O Watson
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009888 (2021)
Rhodococcus equi is a major cause of foal pneumonia and an opportunistic pathogen in immunocompromised humans. While alveolar macrophages constitute the primary replicative niche for R. equi, little is known about how intracellular R. equi is sensed
Externí odkaz:
https://doaj.org/article/2ac9b5fc418b491eb0a4f4d8c3eba144
Autor:
Chi G Weindel, Samantha L Bell, Krystal J Vail, Kelsi O West, Kristin L Patrick, Robert O Watson
Publikováno v:
eLife, Vol 9 (2020)
The Parkinson’s disease (PD)-associated gene leucine-rich repeat kinase 2 (LRRK2) has been studied extensively in the brain. However, several studies have established that mutations in LRRK2 confer susceptibility to mycobacterial infection, suggest
Externí odkaz:
https://doaj.org/article/4caa4bf04ba84861995ba7c4bd7c84fd
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20047 (2011)
Plasmodium falciparum causes the most virulent form of malaria and encodes a large number of molecular chaperones. Because the parasite encounters radically different environments during its lifecycle, many members of this chaperone ensemble may be e
Externí odkaz:
https://doaj.org/article/b12a8692958341f4b44fc4a3fd501b0d
Autor:
Tao Jing, Jeffery S. Cox, Kelsi O West, Pingwei Li, Kristin L. Patrick, Robert O. Watson, Allison R Wagner, A. Phillip West, Sylvia Torres-Odio, Samantha L. Bell, Caitlyn T. Hoffpauir
Publikováno v:
J Immunol
Tripartite motif-containing proteins (TRIMs) play a variety of recently described roles in innate immunity. Although many TRIMs regulate type I IFN expression following cytosolic nucleic acid sensing of viruses, their contribution to innate immune si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::556cf515744928016485d01393233fef
https://doi.org/10.4049/jimmunol.1901511
https://doi.org/10.4049/jimmunol.1901511
Autor:
Jason Karpac, Baoyu Zhao, Pingwei Li, Chi G Weindel, Cory Mabry, Kristin L. Patrick, Eduardo R. Martinez, Phillip West, Aja K. Coleman, Jordan J VanPortfliet, Krystal J Vail, Xiao Zhao, Robert O. Watson, Samantha L Bell
SUMMARYHuman mutations in mitochondrial-associated genes are associated with inflammatory diseases and susceptibility to infection. However, their mechanistic contributions to immune outcomes remain ill-defined. We discovered that the disease-associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9e2f7252780f4ed937aacbe248e920a
https://doi.org/10.1101/2021.11.18.469014
https://doi.org/10.1101/2021.11.18.469014
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
mBio
mBio
Mycobacterium tuberculosis (Mtb) causes one of the deadliest infectious diseases worldwide. Upon infection, Mtb is phagocytosed by macrophages and uses its virulence-associated ESX-1 secretion system to modulate the host cell. We showed previously th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bafcc6ecaf7abb75e360443d7f272dfd
https://journals.asm.org/doi/10.1128/mBio.01871-20
https://journals.asm.org/doi/10.1128/mBio.01871-20
Autor:
Yang Liu, Pengbiao Xu, Jun-Yuan Ji, Xiaofeng Fu, Mengmeng Liu, Fenglei Du, Baoyu Zhao, Samantha L. Bell, Fanxiu Zhu, Arthur Laganowsky, Yuanjiu Lei, Pingwei Li, A. Philip West, Xinsheng Gao, Chang Shu, Banumathi Sankaran, Robert O. Watson, Xueyun Zheng
Publikováno v:
Nature
Nature, vol 569, iss 7758
Nature, vol 569, iss 7758
Nucleic acids from bacteria or viruses induce potent immune responses in infected cells1-4. The detection of pathogen-derived nucleic acids is a central strategy by which the host senses infection and initiates protective immune responses5,6. Cyclic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d3c9e1444d72ffdc524911895f0c75
https://doi.org/10.1038/s41586-019-1228-x
https://doi.org/10.1038/s41586-019-1228-x
Autor:
Chi G. Weindel, Eduardo L. Martinez, Xiao Zhao, Cory J. Mabry, Samantha L. Bell, Krystal J. Vail, Aja K. Coleman, Jordyn J. VanPortfliet, Baoyu Zhao, Allison R. Wagner, Sikandar Azam, Haley M. Scott, Pingwei Li, A. Phillip West, Jason Karpac, Kristin L. Patrick, Robert O. Watson
Publikováno v:
Cell. 185:3214-3231.e23
Although mutations in mitochondrial-associated genes are linked to inflammation and susceptibility to infection, their mechanistic contributions to immune outcomes remain ill-defined. We discovered that the disease-associated gain-of-function allele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa1c9c6f5595b9edba7b01127d4e15a6
https://doi.org/10.1016/j.cell.2022.06.038
https://doi.org/10.1016/j.cell.2022.06.038
Autor:
A. Phillip West, Robert O. Watson, Camila Guerra Martinez, Joshua D. Bryant, Sylvia Torres-Odio, Samantha L. Bell, Yuanjiu Lei, Carl W. Tong, Christine E. Birdwell, Laura Ciaccia West
Publikováno v:
Science Advances. 7
Mitochondrial dysfunction is a key driver of inflammatory responses in human disease. However, it remains unclear whether alterations in mitochondria-innate immune cross-talk contribute to the pathobiology of mitochondrial disorders and aging. Using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7108e75f2d535be54d4f32994e544b20
https://doi.org/10.1126/sciadv.abe7548
https://doi.org/10.1126/sciadv.abe7548