Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Samantha L, Schwartz"'
Autor:
Janani Parameswaran, Nancy Zhang, Elke Braems, Kedamawit Tilahun, Devesh C Pant, Keena Yin, Seneshaw Asress, Kara Heeren, Anwesha Banerjee, Emma Davis, Samantha L Schwartz, Graeme L Conn, Gary J Bassell, Ludo Van Den Bosch, Jie Jiang
Publikováno v:
eLife, Vol 12 (2023)
GGGGCC (G4C2) hexanucleotide repeat expansion in the C9ORF72 gene is the most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The repeat is bidirectionally transcribed and confers gain of toxicity. Howev
Externí odkaz:
https://doaj.org/article/b5c4b7e784d04f559aa8ececa782ffe9
Autor:
Sara E. Gookin, Matthew R. Taylor, Samantha L. Schwartz, Matthew J. Kennedy, Mark L. Dell’Acqua, Kevin C. Crosby, Katharine R. Smith
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 14 (2022)
The nanoscale architecture of synapses has been investigated using multiple super-resolution methods, revealing a common modular structure for scaffolds, neurotransmitter receptors, and presynaptic proteins. This fundamental organization of proteins
Externí odkaz:
https://doaj.org/article/ce3db4c3150a42509ceaf51515256aad
Autor:
Janani Parameswaran, Nancy Zhang, Elke Braems, Kedamawit Tilahun, Devesh C Pant, Keena Yin, Seneshaw Asress, Kara Heeren, Anwesha Banerjee, Emma Davis, Samantha L Schwartz, Graeme L Conn, Gary J Bassell, Ludo Van Den Bosch, Jie Jiang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::711038c3720bbc1e8b5b669bbcb076db
https://doi.org/10.7554/elife.85902.sa2
https://doi.org/10.7554/elife.85902.sa2
Autor:
Brian G. Hiester, Matthew I. Becker, Aaron B. Bowen, Samantha L. Schwartz, Matthew J. Kennedy
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Long-term potentiation (LTP) of excitatory synapses is a major form of plasticity for learning and memory in the central nervous system. While the molecular mechanisms of LTP have been debated for decades, there is consensus that LTP induction activa
Externí odkaz:
https://doaj.org/article/96b7fc19d82f44ee8f4e415176264528
Autor:
Janani Parameswaran, Nancy Zhang, Kedamawit Tilahun, Devesh C. Pant, Ganesh Chilukuri, Seneshaw Asress, Anwesha Banerjee, Emma Davis, Samantha L. Schwartz, Graeme L. Conn, Gary J. Bassell, Jie Jiang
GGGGCC (G4C2) hexanucleotide repeat expansion in the C9orf72 gene is the most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The repeat is bidirectionally transcribed and confers gain of toxicity. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbe09d352dcd8f93266fc4bcf1474dc8
https://doi.org/10.1101/2022.06.06.495030
https://doi.org/10.1101/2022.06.06.495030
Autor:
Shamika Danzy, Virginia K. Vachon, Esther N. Park, Graeme L. Conn, Samantha L. Schwartz, Anice C. Lowen
Publikováno v:
Nucleic Acids Research
2′-5′-Oligoadenylate synthetases (OAS) are innate immune sensors of cytosolic double-stranded RNA (dsRNA) and play a critical role in limiting viral infection. dsRNA binding induces allosteric structural changes in OAS1 that reorganize its cataly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a093557dc2f53f59e701219494fa269
http://europepmc.org/articles/PMC7367156
http://europepmc.org/articles/PMC7367156
Autor:
Samantha L. Schwartz, Debayan Dey, Julia Tanquary, Camden R. Bair, Anice C. Lowen, Graeme L. Conn
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The innate immune system is a collection of essential frontline defenses against infectious pathogens such as viruses. Currently, however, we do not fully understand how one innate immune sensor of double-stranded RNA (dsRNA), oligoadeny
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a329b4a4b33225ff074d4b96d931712
https://doi.org/10.1073/pnas.2107111119
https://doi.org/10.1073/pnas.2107111119
Autor:
Jennifer N. Bourne, Samantha L Schwartz, Olga Prikhodko, Alexandra Lucas, Kevin C. Crosby, Harrison J. Ramsay, Christina S. Winborn, Brooke L. Sinnen, Hannah S. Actor-Engel, Mark L. Dell'Acqua, Katherine R. Smith, Matthew J. Kennedy
Publikováno v:
eNeuro
Secreted amyloid-β (Aβ) peptide forms neurotoxic oligomeric assemblies thought to cause synaptic deficits associated with Alzheimer's disease (AD). Soluble Aβ oligomers (Aβo) directly bind to neurons with high affinity and block plasticity mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a3cd662ac39a6426dae965e984308ba
https://pubmed.ncbi.nlm.nih.gov/34789478
https://pubmed.ncbi.nlm.nih.gov/34789478
Autor:
Aaron B. Bowen, Christina S. Winborn, Dean J Kareemo, Thomas Schwarz, Amos Gutnick, Mason S Kleinjan, Samantha L Schwartz, Ashley M. Bourke, Matthew J. Kennedy
Publikováno v:
The Journal of cell biology. 220(9)
Here we introduce zapalog-mediated endoplasmic reticulum trap (zapERtrap), which allows one to use light to precisely trigger forward trafficking of diverse integral membrane proteins from internal secretory organelles to the cell surface with single
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8663b67731fceb23935c6cfd0b702d2f
https://pubmed.ncbi.nlm.nih.gov/34241635
https://pubmed.ncbi.nlm.nih.gov/34241635
Autor:
Kathleen E. Sullivan, Paul Gray, Debayan Dey, Lars M. Koenig, Daniel F. R. Boehmer, Davide Montin, Matthias Griese, Tomohiro Morio, Tsubasa Okano, Hirokazu Kanegane, Thomas Magg, Francesco Licciardi, Samantha L. Schwartz, Julia Ley-Zaporozhan, Andrés Caballero-Oteyza, Meino Rohlfs, Karl Reiter, Esther N. Park, Jennifer Heimall, Kazutoshi Cho, Michael H. Albert, Brenda M. Calderon, Kento Inoue, Christoph Walz, Christoph Klein, Fabian Hauck, Ronald M. Ferdman, Graeme L. Conn
Analysis of autoinflammatory and immunodeficiency disorders elucidates human immunity and fosters the development of targeted therapies. Oligoadenylate synthetase 1 is a type I interferon-induced, intracellular double-stranded RNA (dsRNA) sensor that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c5d3086f2b9ce81b7c525bee36de15a
https://hdl.handle.net/2318/1878269
https://hdl.handle.net/2318/1878269