Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Samantha K. Segall"'
Autor:
Richard Ohrbach, Célia Marisa Rizzatti-Barbosa, Shad B. Smith, Samantha K. Segall, William Maixner, Roger B. Fillingim, Charles Knott, Pekka T. Männistö, Marc Parisien, Douglas Tsao, Josee Gauthier, Joel D. Greenspan, Marjo Piltonen, Carolina B. Meloto, Marino Convertino, Dmitri V. Zaykin, Luda Diatchenko, Ilkka Reenilä, Svetlana A. Shabalina, Nikolay V. Dokholyan, Gary D. Slade
Publikováno v:
Pain
Supplemental Digital Content is Available in the Text. A catechol-O-methyltransferase genetic marker of pain led to the discovery of an alternative enzyme that acts through dopamine rather than epinephrine, characteristic of reference catechol-O-meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8a66c67c4ae453da23a9facb0281fcc
https://doi.org/10.1097/j.pain.0000000000000273
https://doi.org/10.1097/j.pain.0000000000000273
Autor:
Tim Wiltshire, Danielle Cunningham, Samantha K. Segall, Xia Wen, Carolina B. Meloto, Lisa M. Tarantino, Jeffrey S. Mogil, Svetlana A. Shabalina, Josee Gauthier, Sarasa Tohyama, Loren J. Martin, Luda Diatchenko
Publikováno v:
Pain
Supplemental Digital Content is Available in the Text. A functional mouse Comt allele, associated with pain behaviour, increases Comt expression by inserting an early polyadenylation signal and removing naturally occurring regulatory microRNA signals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0f4267c45f406de5bcb0505a3161b8a
https://doi.org/10.1097/j.pain.0000000000000258
https://doi.org/10.1097/j.pain.0000000000000258
Autor:
Samantha K. Segall, Naim U. Rashid, Inna Belfer, Shad B. Smith, Qian Liu, Gary D. Slade, Robert R. Edwards, William R. Lariviere, William Maixner, Feng Dai, Luda Diatchenko, Eric Bair, Claudia M. Campbell, Jeffrey S. Mogil
Publikováno v:
Pain. 154:1368-1376
The enzyme catechol-O-methyltransferase (COMT) metabolizes catecholamine neurotransmitters involved in a number of physiological functions including pain perception. Both human and mouse COMT genes possess functional polymorphisms contributing to int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43beefcb412f83a2bf5aa0e65b292619
https://doi.org/10.1016/j.pain.2013.04.028
https://doi.org/10.1016/j.pain.2013.04.028
Autor:
Luda Diatchenko, Samantha K. Segall, Tim Wiltshire, Inna Belfer, Ze'ev Seltzer, William Maixner
Publikováno v:
CNS & Neurological Disorders - Drug Targets. 11:222-235
The enzyme catechol-O-methyltransferase (COMT) has been shown to play a critical role in pain perception by regulating levels of epinephrine (Epi) and norepinephrine (NE). Although the key contribution of catecholamines to the perception of pain has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e383df5b692ec1ddc460f1ef781cc3b
https://doi.org/10.2174/187152712800672490
https://doi.org/10.2174/187152712800672490
Autor:
Cindy L. Ehlers, Kimberly L. Seaton-Smith, Samantha K. Segall, Ian R. Gizer, David A. Gilder, Heidi S. Feiler, Kirk C. Wilhelmsen, James V. Lee, Cassandra Vieten
Publikováno v:
Drug and Alcohol Dependence. 113:125-132
Ample data suggest that alcohol dependence represents a heritable condition, and several research groups have performed linkage analysis to identify genomic regions influencing this disorder. In the present study, a genome-wide linkage scan for alcoh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e348da0310500333da21201f5da914
https://doi.org/10.1016/j.drugalcdep.2010.07.017
https://doi.org/10.1016/j.drugalcdep.2010.07.017
Comt1 genotype and expression predicts anxiety and nociceptive sensitivity in inbred strains of mice
Autor:
Laura Grabowski-Boase, Samantha K. Segall, J. S. Marron, Lisa M. Tarantino, Tim Wiltshire, Andrea G. Nackley, William R. Lariviere, Gary D. Slade, Luda Diatchenko, Josee Gauthier, Thomas M. Maynard, Janice S. Bailey, Brian M. Steffy, X. Lu, J. R. Walker
Publikováno v:
Genes, Brain and Behavior. 9:933-946
Catechol-O-methyltransferase (COMT) is an ubiquitously expressed enzyme that maintains basic biologic functions by inactivating catechol substrates. In humans, polymorphic variance at the COMT locus has been associated with modulation of pain sensiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a5bb93e66c3c7c5f25d7dc03e59d55b
https://doi.org/10.1111/j.1601-183x.2010.00633.x
https://doi.org/10.1111/j.1601-183x.2010.00633.x
Autor:
Cindy L. Ehlers, Cassandra Vieten, James V. Lee, Ian R. Gizer, Kirk C. Wilhelmsen, Heidi S. Feiler, Samantha K. Segall, K. L. Seaton-Smith, David A. Gilder
Publikováno v:
Psychological Medicine. 41:799-808
Tobacco-related illnesses have been estimated to claim 435,000 lives annually, thus constituting a serious and costly public health issue (Mokdad et al., 2004). Twin studies suggest a substantial genetic component to the development of nicotine depen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87db37eadeb5ade170bc958ce03ef154
https://doi.org/10.1017/s0033291710001273
https://doi.org/10.1017/s0033291710001273
Autor:
Weike Lai, Kelen Freitas, Shakir Al Sharari, Christopher I. Richards, M. Imad Damaj, Jaclyn Marcovitz, Michael R. Post, Jean-Sebastien Austin, Sarah C. R. Lummis, Luda Diatchenko, Sarah E Clarke, Ardem Patapoutian, Dennis A. Dougherty, Marshall Devor, Jeffrey S. Mogil, Dmitri V. Zaykin, Eske Kvanner Aasvang, Henry A. Lester, Loren J. Martin, John R. Walker, Walrati Limapichat, William Maixner, Jeff Janes, Reinhard Bittner, Feng Dai, Andrew I. Su, Shad B. Smith, Peter Maxwell Slepian, Jeffrey S. Wieskopf, Jayanti Mathur, Mona Alqazzaz, Samantha K. Segall, Jie Zhang, Uwe Maskos, Ryan M. Drenan, Alexander H. Tuttle, Henrik Kehlet, Inna Belfer, Jean-Pierre Changeux, Robert E. Sorge, Gary D. Slade
Publikováno v:
Science Translational Medicine
Science Translational Medicine, American Association for the Advancement of Science, 2015, 7 (287), pp.287ra72-287ra72. ⟨10.1126/scitranslmed.3009986⟩
Science Translational Medicine, 2015, 7 (287), pp.287ra72-287ra72. ⟨10.1126/scitranslmed.3009986⟩
Science Translational Medicine, American Association for the Advancement of Science, 2015, 7 (287), pp.287ra72-287ra72. ⟨10.1126/scitranslmed.3009986⟩
Science Translational Medicine, 2015, 7 (287), pp.287ra72-287ra72. ⟨10.1126/scitranslmed.3009986⟩
International audience; Chronic pain is a highly prevalent and poorly managed human health problem. We used microarray-based expression genomics in 25 inbred mouse strains to identify dorsal root ganglion (DRG)-expressed genetic contributors to mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8f232e558171d972c48dbfb4909aa91
https://doi.org/10.1126/scitranslmed.3009986
https://doi.org/10.1126/scitranslmed.3009986
Autor:
Matthew L. Warman, Samantha K. Segall, Anna-Elina Lehesjoki, James V. Lee, Heidi S. Feiler, Marni J. Falk, Kathleen Maxwell, Juha Kolehmainen, Max Wiznitzer, Ann Liz Träskelin, Nathaniel H. Robin, Derek E. Neilson, Kirk C. Wilhelmsen
Publikováno v:
American Journal of Medical Genetics Part A. :23-28
We describe eight members from two large Amish kindreds who share a phenotype characterized by early-onset pigmentary retinopathy and myopia, global developmental delay and mental retardation, microcephaly, short stature, hypotonia, joint hyperextens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77bbb1286c7cf208aec599d6057bc5ff
https://doi.org/10.1002/ajmg.a.30033
https://doi.org/10.1002/ajmg.a.30033
Autor:
Kirk C. Wilhelmsen, Samantha K. Segall, Heidi S. Feiler, Tom L. Smith, Jelger Kalmijn, James V. Lee, Marc A. Schuckit
Publikováno v:
Alcoholism: Clinical & Experimental Research. 27:1041-1047
A low level of response (LR) to alcohol seems to relate to a substantial proportion of the risk for alcoholism and to have significant heritability.This report describes the results of a genome-wide segregation analysis for the first 139 pairs of ful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2703fce04df2db3a0fbbaa672b2e1fd5
https://doi.org/10.1097/01.alc.0000075551.02714.63
https://doi.org/10.1097/01.alc.0000075551.02714.63