Defining correlates of protection for mammalian livestock vaccines against high-priority viral diseases

Autor: Samantha K. Davis, Fan Jia, Quentin G. Wright, Md. Tanjir Islam, Andrew Bean, Daniel Layton, David T. Williams, Stacey E. Lynch

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

Enhancing livestock biosecurity is critical to safeguard the livelihoods of farmers, global and local economies, and food security. Vaccination is fundamental to the control and prevention of exotic and endemic high-priority infectious livestock dise

Externí odkaz: https://doaj.org/article/3aa233ebdc7646c093b64f5c1bd6f9a3

Systems serology detects functionally distinct coronavirus antibody features in children and elderly

Autor: Kevin J. Selva, Carolien E. van de Sandt, Melissa M. Lemke, Christina Y. Lee, Suzanne K. Shoffner, Brendon Y. Chua, Samantha K. Davis, Thi H. O. Nguyen, Louise C. Rowntree, Luca Hensen, Marios Koutsakos, Chinn Yi Wong, Francesca Mordant, David C. Jackson, Katie L. Flanagan, Jane Crowe, Shidan Tosif, Melanie R. Neeland, Philip Sutton, Paul V. Licciardi, Nigel W. Crawford, Allen C. Cheng, Denise L. Doolan, Fatima Amanat, Florian Krammer, Keith Chappell, Naphak Modhiran, Daniel Watterson, Paul Young, Wen Shi Lee, Bruce D. Wines, P. Mark Hogarth, Robyn Esterbauer, Hannah G. Kelly, Hyon-Xhi Tan, Jennifer A. Juno, Adam K. Wheatley, Stephen J. Kent, Kelly B. Arnold, Katherine Kedzierska, Amy W. Chung

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Antibody responses to SARS-CoV-2 are critical in the immune response to infection, but the potential cross-reactivity to other human corona viruses is poorly appreciated. Here the authors apply a systems based approach to characterise the antibody re

Externí odkaz: https://doaj.org/article/b3735969bc2442d3bede1a835ba02866

Simultaneous evaluation of antibodies that inhibit SARS-CoV-2 variants via multiplex assay

Autor: Ester Lopez, Ebene R. Haycroft, Amy Adair, Francesca L. Mordant, Matthew T. O’Neill, Phillip Pymm, Samuel J. Redmond, Wen Shi Lee, Nicholas A. Gherardin, Adam K. Wheatley, Jennifer A. Juno, Kevin J. Selva, Samantha K. Davis, Samantha L. Grimley, Leigh Harty, Damian F.J. Purcell, Kanta Subbarao, Dale I. Godfrey, Stephen J. Kent, Wai-Hong Tham, Amy W. Chung

Publikováno v: JCI Insight, Vol 6, Iss 16 (2021)

The SARS-CoV-2 receptor binding domain (RBD) is both the principal target of neutralizing antibodies and one of the most rapidly evolving domains, which can result in the emergence of immune escape mutations, limiting the effectiveness of vaccines an

Externí odkaz: https://doaj.org/article/6496c3fb4c0b4160a25ed36ea7212210

Lasting first impression: Pre-existing immunity restricts mucosal antibody responses during Omicron breakthrough

Autor: Kevin John Selva, Pradhipa Ramanathan, Ebene Regina Haycroft, Arnold Reynaldi, Deborah Cromer, Chee Wah Tan, Lin-Fa Wang, Bruce D Wines, P Mark Hogarth, Laura E Downie, Samantha K Davis, Ruth Amy Purcell, Helen E Kent, Jennifer A Juno, Adam K Wheatley, Miles P Davenport, Stephen John Kent, Amy W Chung

SummaryUnderstanding mucosal antibody responses from SARS-CoV-2 infection and/or vaccination is crucial to develop strategies for longer term immunity, especially against emerging viral variants. We profiled serial paired mucosal and plasma antibodie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9007e798bc0d3de77a7f5c418ba1ad8c
https://doi.org/10.1101/2023.03.28.23287848

Systems serology detects functionally distinct coronavirus antibody features in children and elderly

Autor: Allen C. Cheng, Francesca L Mordant, Katherine Kedzierska, Keith J. Chappell, Daniel Watterson, Brendon Y. Chua, Hannah G. Kelly, Suzanne K. Shoffner, Jane Crowe, Carolien E. van de Sandt, Melissa M. Lemke, Naphak Modhiran, Bruce D. Wines, Fatima Amanat, Thi H. O. Nguyen, Adam K. Wheatley, Marios Koutsakos, Wen Shi Lee, Hyon-Xhi Tan, Luca Hensen, Kelly B. Arnold, David C. Jackson, Paul R. Young, Amy W. Chung, Paul V. Licciardi, Katie L. Flanagan, Shidan Tosif, Samantha K Davis, Louise C. Rowntree, Chinn Yi Wong, Jennifer A Juno, Stephen J. Kent, Nigel W Crawford, P. Mark Hogarth, Philip Sutton, Melanie R Neeland, Robyn Esterbauer, Kevin J. Selva, Florian Krammer, Denise L. Doolan, Christina Lee

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, 12(1):2037
Nature Communications
Nature communications, 12(1). Nature Publishing Group

The hallmarks of COVID-19 are higher pathogenicity and mortality in the elderly compared to children. Examining baseline SARS-CoV-2 cross-reactive immunological responses, induced by circulating human coronaviruses (hCoVs), is needed to understand su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce261502baebcd38da10bcf6b67f9fcd
https://doaj.org/article/b3735969bc2442d3bede1a835ba02866