Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Samantha J. Turnbull"'
Autor:
David J Pinato, Chara Stavraka, Michael J Flynn, Martin D Forster, Séan M O'Cathail, Michael J Seckl, Rebecca S Kristeleit, David Olmos, Samantha J Turnbull, Sarah P Blagden
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e83279 (2014)
Adequate organ function and good performance status (PS) are common eligibility criteria for phase I trials. As inflammation is pathogenic and prognostic in cancer we investigated the prognostic performance of inflammation-based indices including the
Externí odkaz:
https://doaj.org/article/2edb1a12d61e4577bf54b5381ef4a2ae
Autor:
Lakshmi Srinivasan, Yvonne Ware, Kelledy Manson, Asaf Poran, Benjamin Trapp, Joel Greshock, Mark M. Awad, Dominik Barthelme, Dewi Harjanto, Victoria Kohler, Ying S. Ting, Richard B. Gaynor, Yuting Huang, Matthew D. Hellmann, Samantha J. Turnbull, Siwen Hu-Lieskovan, Ed Fritsch, Meghan E. Bushway, Jessica J. Lin, Lisa D. Cleary, Bartosz Chmielowski, Zhengping Huang, Michael S. Rooney, Terence W. Friedlander, Rana H. Besada, Patrick A. Ott, Zakaria S. Khondker, Mark DeMario, Kristen N. Balogh, Aung Naing, Melissa A. Moles, Riley R. Curran, Kim Margolin, Nina Bhardwaj, Tracey E. Sciuto, Jesse Z. Dong, Ramaswamy Govindan, Julian Scherer, Amy Wanamaker
Publikováno v:
Cell. 183(2)
Summary Neoantigens arise from mutations in cancer cells and are important targets of T cell-mediated anti-tumor immunity. Here, we report the first open-label, phase Ib clinical trial of a personalized neoantigen-based vaccine, NEO-PV-01, in combina
Autor:
Susan C Short, Elizabeth S. Appleton, Gemma Migneco, David Taggart, Simon Thomson, Gerard J. Nuovo, Lucy F. Stead, Sergio A. Quezada, Samantha J. Turnbull, Adel Samson, Philip van Hille, Richard G. Vile, Julia V. Cockle, D. Beirne, Fiona Collinson, Fiona Errington-Mais, Karen Scott, Peter Selby, Euan S. Polson, Kevin J. Harrington, Erica B. Wilson, Heiko Wurdak, Martin Fuller, Stephen Griffin, Jill Thompson, Timothy Kottke, Hardev Pandha, Gnanamurthy Sivakumar, Chris Twelves, Ailsa Rose, Christy Ralph, Andrew Furness, Elizabeth Ilett, Robert Corns, Emma West, D. Alan Anthoney, Matthew C. Coffey, Ryan K. Mathew, Alan Melcher
Immune checkpoint inhibitors, including those targeting programmed cell death protein 1 (PD-1), are reshaping cancer therapeutic strategies. Evidence suggests, however, that tumor response and patient survival are determined by tumor programmed death
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4899fce1ad145ea879d424f0b5ba845
Autor:
Samantha J. Turnbull, Kevin J. Harrington, Christy Ralph, Elizabeth S. Appleton, Alan Melcher, Emma West, Karen Scott, Hardev Pandha
Publikováno v:
Expert Opinion on Biological Therapy. 15:1517-1530
Metastatic melanoma continues to present a significant therapeutic challenge, with an incidence rate rising faster than that of any other cancer. The last 5 years have seen a revolution in the development of new treatments for advanced melanoma, with
Autor:
Christy Ralph, Adel Samson, Chris Twelves, M. Lusky, E. Tidswell, Jennifer Kingston, Kaïdre Bendjama, M. Johnpulle, Alan Melcher, Samantha J. Turnbull, Emma West, Giles J. Toogood, Alan Anthoney, Fiona Collinson, N. Stojkowitz, Karen Scott
Publikováno v:
Annals of Oncology. 30:v496
Background Oncolytic viruses constitute a promising modality of cancer therapy. Pexa-Vec, a Thymidine Kinase-Deactivated Vaccinia Virus expressing GM-CSF, has been shown to target tumor tissue after intravenous (i.v.) administration (Breitbach C.J. e
Autor:
Sarah P. Blagden, David J. Pinato, Martin Forster, Sean M. O'Cathail, Samantha J. Turnbull, Rebecca Kristeleit, Chara Stavraka, Michael J. Seckl, Michael Flynn, Sayed Babar
Publikováno v:
Cancer. 120:262-270
BACKGROUND Several prognostic indices have been devised to optimize patient selection for phase 1 oncology trials with no consensus as to the optimal score and none qualifying as a marker of treatment response. METHODS Multivariate predictors of over
Autor:
Emma L. Tidswell, Christy Ralph, Jenny F. Seligmann, Samantha J. Turnbull, Karen Scott, Matthew T. Seymour, Emma West, Alan Melcher
Publikováno v:
Journal of Clinical Oncology. 36:e15635-e15635
e15635Background: High peripheral blood NLR is a poor prognostic marker in cancer patients. We investigated the relationship between NLR and measured IRs in patients with chemo-naive aCRC and the m...
Autor:
Kaïdre Bendjama, Alan Melcher, Samantha J. Turnbull, Fiona Collinson, Samantha Noutch, Karen Scott, Giles J. Toogood, Alan Anthoney, Chris Twelves, Michel Homerin, Emma West, Adel Samson, Jennifer Kingston, Christy Ralph, Nicolas Stojkowitz, Emma L. Tidswell, Michelle Johnpulle
Publikováno v:
Journal of Clinical Oncology. 36:3092-3092
3092Background: Oncolytic viruses (OV) constitute a promising modality of cancer therapy. Intra-tumoral administration has yielded encouraging clinical results, but restricted the use of OV to tumo...
Autor:
Emma L. Tidswell, Samantha J. Turnbull, Emma West, Jenny F. Seligmann, Christy Ralph, Karen Scott, Alan Melcher, Matthew T. Seymour
Publikováno v:
Annals of Oncology. 28:v582
Autor:
Sarah P. Blagden, David J. Pinato, Martin Forster, Sean M. O'Cathail, Michael J. Seckl, Chara Stavraka, Michael Flynn, Rebecca Kristeleit, David Olmos, Samantha J. Turnbull
Publikováno v:
PLoS ONE
e83279
PLoS ONE, Vol 9, Iss 1, p e83279 (2014)
e83279
PLoS ONE, Vol 9, Iss 1, p e83279 (2014)
Background: Adequate organ function and good performance status (PS) are common eligibility criteria for phase I trials. As inflammation is pathogenic and prognostic in cancer we investigated the prognostic performance of inflammation-based indices i