Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Samantha J. Spratley"'
Autor:
Stacey E. Chin, Christina Schindler, Lisa Vinall, Roger B. Dodd, Lisa Bamber, Sandrine Legg, Anna Sigurdardottir, D. Gareth Rees, Tim I. M. Malcolm, Samantha J. Spratley, Cecilia Granéli, Jonathan Sumner, Natalie J. Tigue
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Chemical inducer of dimerization (CID) modules can be used effectively as molecular switches to control biological processes, and thus there is significant interest within the synthetic biology community in identifying novel CID systems. To
Externí odkaz:
https://doaj.org/article/1c4fb2f0a98149f7bb083c8fbced398e
Publikováno v:
Contact, Vol 4 (2021)
Saposins are lipid transfer proteins required for the degradation of sphingolipids in the lysosome. These small proteins bind lipids by transitioning from a closed, monomeric state to an open conformation exposing a hydrophobic surface that binds and
Externí odkaz:
https://doaj.org/article/f16a0239b43e4d07a7ee17ab3e4f21b6
Autor:
Chris H. Hill, Georgia M. Cook, Samantha J. Spratley, Stuart Fawke, Stephen C. Graham, Janet E. Deane
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Lysosomal degradation of sphingolipids requires lipid-binding saposin proteins and hydrolytic enzymes. Here the authors present the crystal structure of the hydrolase β-galactocerebrosidase in complex with saposin SapA and give insights into the gly
Externí odkaz:
https://doaj.org/article/2892fdb00d5d43eb9babf8bf3fb7a3dc
Autor:
Janet E. Deane, Stig H. Christensen, Randy J. Read, Samantha J. Spratley, Nigel W. Moriarty, Chris H. Hill, Agnete H. Viuff, Henrik H. Jensen, Stéphane Salamone
Publikováno v:
Chemical Science
Modified azasugar molecules have been synthesized and characterized as excellent pharmacological chaperone candidates to treat the neurodegenerative disorder Krabbe disease.
Krabbe disease is a devastating neurodegenerative disorder characterize
Krabbe disease is a devastating neurodegenerative disorder characterize
Sphingolipids are essential components of cellular membranes and defects in their synthesis or degradation cause severe human diseases. The efficient degradation of sphingolipids in the lysosome requires lipid-binding saposin proteins and hydrolytic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67b6d4592713eccc423c36b73b31af56
https://doi.org/10.1101/112029
https://doi.org/10.1101/112029
Autor:
Sarah E. Pearce, Sahra Borges, Samantha J. Spratley, Heike Döppler, Peter Storz, Ligia I. Bastea
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 5, p e98090 (2014)
PLoS ONE, Vol 9, Iss 5, p e98090 (2014)
Background Protein kinase D (PKD) enzymes regulate cofilin-driven actin reorganization and directed cell migration through both p21-activated kinase 4 (PAK4) and the phosphatase slingshot 1L (SSH1L). The relative contributions of different endogenous
Autor:
Nisha Durand, Sarah E. Pearce, Samantha J. Spratley, Heike Döppler, Ligia I. Bastea, Peter Storz
Publikováno v:
The Biochemical journal. 455(2)
PAKs (p21-activated kinases) are effectors of RhoGTPases. PAK4 contributes to regulation of cofilin at the leading edge of migrating cells through activation of LIMK (Lin-11/Isl-1/Mec-3 kinase). PAK4 activity is regulated by an autoinhibitory domain
Publikováno v:
The Journal of biological chemistry. 286(39)
Dynamic reorganization of the actin cytoskeleton at the leading edge is required for directed cell migration. Cofilin, a small actin-binding protein with F-actin severing activities, is a key enzyme initiating such actin remodeling processes. Cofilin
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 70:C451-C451
Glycosphingolipids are ubiquitous components of mammalian cell membranes, and defects in their catabolism by lysosomal enzymes cause a diverse array of diseases. Deficiencies in the enzyme β-galactocerebrosidase (GALC) cause Krabbe disease, a devast
Autor:
Samantha J. Spratley, Peter Storz
Publikováno v:
Cancer Research. 71:2364-2364
During early metastatic events in cancer, reorganization of the actin cytoskeleton must occur to allow for cell invasion and migration. A key enzyme initiating actin remodeling at the leading edge is Cofilin, a small actin binding protein of the ADF/