Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Samantha J. Orenstein"'
Autor:
Liliana Menalled, Bassem F. El-Khodor, Monica Patry, Mayte Suárez-Fariñas, Samantha J. Orenstein, Benjamin Zahasky, Christina Leahy, Vanessa Wheeler, X. William Yang, Marcy MacDonald, A. Jennifer Morton, Gill Bates, Janet Leeds, Larry Park, David Howland, Ethan Signer, Allan Tobin, Daniela Brunner
Publikováno v:
Neurobiology of Disease, Vol 35, Iss 3, Pp 319-336 (2009)
Huntington's disease (HD) is one of the few neurodegenerative diseases with a known genetic cause, knowledge that has enabled the creation of animal models using genetic manipulations that aim to recapitulate HD pathology. The study of behavioral and
Externí odkaz:
https://doaj.org/article/af9fd89edd134459a71f0f5fc6d5f00a
Autor:
Mayte Suárez-Fariñas, Liliana B. Menalled, Christina Leahy, Larry Park, Allan J. Tobin, Ethan Signer, Vanessa C. Wheeler, Monica Patry, Daniela Brunner, Marcy E. MacDonald, Janet M. Leeds, A. Jennifer Morton, X. William Yang, David Howland, Bassem F. El-Khodor, GP Bates, Benjamin Zahasky, Samantha J. Orenstein
Publikováno v:
Neurobiology of Disease, Vol 35, Iss 3, Pp 319-336 (2009)
Huntington's disease (HD) is one of the few neurodegenerative diseases with a known genetic cause, knowledge that has enabled the creation of animal models using genetic manipulations that aim to recapitulate HD pathology. The study of behavioral and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::557ce41620d6b4eb0ad112bf58a91534
https://doi.org/10.1016/j.nbd.2009.05.007
https://doi.org/10.1016/j.nbd.2009.05.007
Autophagy is a lysosomal degradative process which recycles cellular waste and eliminates potentially toxic damaged organelles and protein aggregates. The important cytoprotective functions of autophagy are demonstrated by the diverse pathogenic cons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66a7187b21855c75528414fd14133b49
https://europepmc.org/articles/PMC3694736/
https://europepmc.org/articles/PMC3694736/
Autor:
Angel Raya, William T. Dauer, Antonella Consiglio, Etty Cortes, Esperanza Arias, David Sulzer, Hiroshi Koga, Lawrence S. Honig, Irene Fernandez-Carasa, Sheng-Hang Kuo, Inmaculada Tasset, Samantha J. Orenstein, Ana Maria Cuervo
Publikováno v:
NAT NEUROSCI
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
Nature neuroscience
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
Nature neuroscience
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson's disease. We found LRRK2 to be degraded in lysosomes by chaperone-mediated autophagy (CMA), whereas the most common pathogenic mutant form of LRRK2, G2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6394f3875657e2b975c9d1b079a57eb1
http://hdl.handle.net/11379/453759
http://hdl.handle.net/11379/453759
Autor:
Susmita Kaushik, Maria Kon, Marta Martinez-Vicente, Sunandini Sridhar, Samantha J. Orenstein, Ana Maria Cuervo, Urmi Bandyopadhyay, Esther Wong, Roberta Kiffin
Publikováno v:
Journal of cell science. 124(Pt 4)
Chaperone-mediated autophagy (CMA) is an intracellular catabolic pathway that mediates the degradation of a selective subset of cytosolic proteins in lysosomes ([Dice, 2007][1]; [Cuervo, 2010][2]; [Kon and Cuervo, 2010][3]; [Orenstein and Cuervo, 201
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4b6816552d0ae46dcd9b3548bb891d9
https://pubmed.ncbi.nlm.nih.gov/21282471
https://pubmed.ncbi.nlm.nih.gov/21282471
Chaperone-mediated autophagy (CMA) is a selective lysosomal pathway for the degradation of cytosolic proteins. We review in this work some of the recent findings on this pathway regarding the molecular mechanisms that contribute to substrate targetin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a220250cea65c36b97d03869d242b2e
https://europepmc.org/articles/PMC2914824/
https://europepmc.org/articles/PMC2914824/
Publikováno v:
The Comparative Biology of Aging ISBN: 9789048134649
The lysosome, the organelle with the greatest degradative capability in the cell, is an essential component of the systems responsible for cellular quality control. Lysosome malfunctioning alters cellular homeostasis and has been proposed to contribu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a9de37c9afc84f2323bc0a750e8b78a
https://doi.org/10.1007/978-90-481-3465-6_10
https://doi.org/10.1007/978-90-481-3465-6_10