Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Samantha J Hutten"'
Autor:
Michael Bartl, Mohammed Dakna, Douglas Galasko, Samantha J Hutten, Tatiana Foroud, Marian Quan, Kenneth Marek, Andrew Siderowf, Jonas Franz, Claudia Trenkwalder, Brit Mollenhauer, Parkinson’s Progression Markers Initiative
Publikováno v:
PLoS ONE, Vol 16, Iss 10, p e0257372 (2021)
AimSeveral pathophysiological processes are involved in Parkinson's disease (PD) and could inform in vivo biomarkers. We assessed an established biomarker panel, validated in Alzheimer's Disease, in a PD cohort.MethodsLongitudinal cerebrospinal fluid
Externí odkaz:
https://doaj.org/article/2dd6276ca17c4e6e850a0ed593e32cff
Autor:
Sergio Kaiser, Luqing Zhang, Brit Mollenhauer, Jaison Jacob, Simonne Longerich, Jorge Del-Aguila, Jacob Marcus, Neha Raghavan, David Stone, Olumide Fagboyegun, Douglas Galasko, Mohammed Dakna, Bilada Bilican, Mary Dovlatyan, Anna Kostikova, Jingyao Li, Brant Peterson, Michael Rotte, Vinicius Sanz, Tatiana Foroud, Samantha J. Hutten, Mark Frasier, Hirotaka Iwaki, Andrew Singleton, Ken Marek, Karen Crawford, Fiona Elwood, Mirko Messa, Pablo Serrano-Fernandez
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-13 (2023)
Abstract The pathogenesis and clinical heterogeneity of Parkinson’s disease (PD) have been evaluated from molecular, pathophysiological, and clinical perspectives. High-throughput proteomic analysis of cerebrospinal fluid (CSF) opened new opportuni
Externí odkaz:
https://doaj.org/article/8a3707f40aec4528b1d8d9e56c321bac
Autor:
Christina D. Orrù, Thong C. Ma, Andrew G. Hughson, Bradley R. Groveman, Ankit Srivastava, Douglas Galasko, Rachel Angers, Patrick Downey, Karen Crawford, Samantha J. Hutten, Un Jung Kang, Byron Caughey
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 8, Iss 2, Pp 374-384 (2021)
Abstract Background Assays that specifically measure α‐synuclein seeding activity in biological fluids could revolutionize the diagnosis of Parkinson’s disease. Recent improvements in α‐synuclein real‐time quaking‐induced conversion assay
Externí odkaz:
https://doaj.org/article/65c3405b7b8b4e7b97f6df54b65d2358
Autor:
Roy N. Alcalay, Pavlina Wolf, Ming Sum Ruby Chiang, Karolina Helesicova, Xiaokui Kate Zhang, Kalpana Merchant, Samantha J. Hutten, Clemens Scherzer, Chelsea Caspell‐Garcia, Cornelis Blauwendraat, Tatiana Foroud, Kelly Nudelman, Ziv Gan‐Or, Tanya Simuni, Lana M. Chahine, Oren Levy, Dandi Zheng, Gen Li, Sergio Pablo Sardi, The Parkinson’s Progression Markers Initiative
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 7, Iss 10, Pp 1816-1830 (2020)
Abstract Objective Reduction in glucocerebrosidase (GCase; encoded by GBA) enzymatic activity has been linked to Parkinson’s disease (PD). Here, we correlated GCase activity and PD phenotype in the Parkinson’s Progression Markers Initiative (PPMI
Externí odkaz:
https://doaj.org/article/535af180a5f746bf9df8a123694b6688
Autor:
Michael C. Brumm, Andrew Siderowf, Tanya Simuni, Elliot Burghardt, Seung Ho Choi, Chelsea Caspell-Garcia, Lana M. Chahine, Brit Mollenhauer, Tatiana Foroud, Douglas Galasko, Kalpana Merchant, Vanessa Arnedo, Samantha J. Hutten, Alyssa N. O’Grady, Kathleen L. Poston, Caroline M. Tanner, Daniel Weintraub, Karl Kieburtz, Kenneth Marek, Christopher S. Coffey
BackgroundIdentifying a meaningful progression metric for Parkinson’s disease (PD) that reflects heterogeneity remains a challenge.ObjectiveTo assess the frequency and baseline predictors of progression to clinically relevant motor and non-motor PD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d8adbd7a834f151007c6f2ea33c410e
https://doi.org/10.1101/2023.05.23.23290344
https://doi.org/10.1101/2023.05.23.23290344
Autor:
Andrew Siderowf, Luis Concha-Marambio, David-Erick Lafontant, Carly M. Farris, Yihua Ma, Paula A. Urenia, Hieu Nguyen, Roy N. Alcalay, Lana M. Chahine, Tatiana Foroud, Douglas Galasko, Karl Kieburtz, Kalpana Merchant, Brit Mollenhauer, Kathleen L. Poston, John Seibyl, Tanya Simuni, Caroline M. Tanner, Daniel Weintraub, Aleksandar Videnovic, Seung Ho Choi, Ryan Kurth, Chelsea Caspell-Garcia, Christopher S. Coffey, Mark Frasier, Luis M. A. Oliveira, Samantha J. Hutten, Todd Sherer, Kenneth Marek, Claudio Soto
SummaryBackgroundRecent research demonstrates that α-synuclein seed amplification assays (αSyn-SAA) accurately differentiate Parkinson’s disease (PD) patients from healthy controls (HC). We used the well-characterized, multicenter Parkinson’s P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7780ebcaeb951254ceeebb401c275281
https://doi.org/10.1101/2023.02.27.23286156
https://doi.org/10.1101/2023.02.27.23286156
Autor:
Nripesh Prasad, J. Raphael Gibbs, Tobias Fehlman, Alyssa Reimer, Kendall Van Keuren-Jensen, Tatiana Foroud, Arthur W. Toga, Samantha J. Hutten, Timothy G. Whitsett, Shawn Levy, Mark Frasier, Ivo Violich, Karen Crawford, Samantha Hutten, Madison Robison, Andreas Keller, Eric Alsop, Fabian Kern, Parkinson Progression Marker Initiative, Elizabeth Hutchins, Mark R. Cookson, David Craig, Seungchan Kim, Bradford Casey
Publikováno v:
Nature Aging. 1:734-747
Changes in the blood-based RNA transcriptome have the potential to inform biomarkers of Parkinson’s disease (PD) progression. Here we sequenced a discovery set of whole-blood RNA species in 4,871 longitudinally collected samples from 1,570 clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8ac73dc842d1ccd3353972b2e2291b1
https://doi.org/10.1038/s43587-021-00088-6
https://doi.org/10.1038/s43587-021-00088-6
Autor:
Christian Deuschle, Inga Liepelt-Scarfone, Gerrit Machetanz, Michelle M. Mielke, Ingolf Lachmann, Ruby Chiang, Claudia Schulte, Hyejung Park, Katharina Waniek, Walter Maetzler, Ingeborg Krägeloh-Mann, Stefanie Lerche, S. Pablo Sardi, Clemens R. Scherzer, Daniela Berg, Kathrin Brockmann, Xuan Mai Petterson, Isabel Wurster, Ann Kathrin Hauser, Douglas Galasko, Brit Mollenhauer, Milan Zimmermann, Benjamin Roeben, Judith Böhringer, Samantha J. Hutten, Thomas Gasser, Bing Wang
Publikováno v:
Movement disorders 36(5), 1216-1228 (2021). doi:10.1002/mds.28472
Background With pathway-specific trials in PD associated with variants in the glucocerebrosidase gene (PDGBA ) under way, we need markers that confirm the impact of genetic variants in patient-derived biofluids in order to allow patient stratificatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::745d5d85c91896a1fbffc64c3f3a16c6
https://doi.org/10.1002/mds.28472
https://doi.org/10.1002/mds.28472
Autor:
Aleksandar Videnovic, Hyunkeun Ryan Cho, Tanya Simuni, Wolfgang H. Oertel, Lana M. Chahine, Amy W. Amara, Cristina Simonet, Tatiana Foroud, Michael C. Brumm, Kenneth Marek, Elliot Burghardt, Brit Mollenhauer, Kathleen L. Poston, Alex Iranzo, Andrew Siderowf, Daniel Weintraub, Douglas Galasko, Samantha J. Hutten, Birgit Högl, Ana Fernández-Arcos, Kalpana Merchant, Chelsea Caspell-Garcia, Eduardo Tolosa, Karl Kieburtz, Christopher S. Coffey, Caroline M. Tanner
Publikováno v:
Annals of Clinical and Translational Neurology
Introduction Individuals with idiopathic rapid eye movement sleep behavior disorder (iRBD) are at high risk for a clinical diagnosis of an α‐synucleinopathy (aSN). They could serve as a key population for disease‐modifying trials. Abnormal dopam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4695814ea7e1315e92db7cfe2b1c7017
http://europepmc.org/articles/PMC7818144
http://europepmc.org/articles/PMC7818144
Autor:
Pavlina Wolf, Samantha J. Hutten, Clemens R. Scherzer, Ziv Gan-Or, Ming Sum Ruby Chiang, Dandi Zheng, Sergio Pablo Sardi, Tanya Simuni, Kalpana Merchant, Chelsea Caspell-Garcia, Tatiana Foroud, Xiaokui Kate Zhang, Roy N. Alcalay, Parkinson's Progression Markers Initiative, Kelly N.H. Nudelman, Cornelis Blauwendraat, Oren A. Levy, Karolina Helesicova, Gen Li, Lana M. Chahine
Publikováno v:
Annals of Clinical and Translational Neurology
Annals of Clinical and Translational Neurology, Vol 7, Iss 10, Pp 1816-1830 (2020)
Annals of Clinical and Translational Neurology, Vol 7, Iss 10, Pp 1816-1830 (2020)
Author(s): Alcalay, Roy N; Wolf, Pavlina; Chiang, Ming Sum Ruby; Helesicova, Karolina; Zhang, Xiaokui Kate; Merchant, Kalpana; Hutten, Samantha J; Scherzer, Clemens; Caspell-Garcia, Chelsea; Blauwendraat, Cornelis; Foroud, Tatiana; Nudelman, Kelly; G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b971a0f83da7fe3e33b13cb0976b7b4
http://europepmc.org/articles/PMC7545591
http://europepmc.org/articles/PMC7545591