Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Samantha J Batista"'
Autor:
Michael A Kovacs, Maureen N Cowan, Isaac W Babcock, Lydia A Sibley, Katherine Still, Samantha J Batista, Sydney A Labuzan, Ish Sethi, Tajie H Harris
Publikováno v:
eLife, Vol 11 (2022)
The discovery of meningeal lymphatic vessels that drain the CNS has prompted new insights into how immune responses develop in the brain. In this study, we examined how T cell responses against CNS-derived antigen develop in the context of infection.
Externí odkaz:
https://doaj.org/article/994ef1d8384d4b9a86220589942e318d
Autor:
Maureen N Cowan, Michael A Kovacs, Ish Sethi, Isaac W Babcock, Katherine Still, Samantha J Batista, Carleigh A O'Brien, Jeremy A Thompson, Lydia A Sibley, Sydney A Labuzan, Tajie H Harris
Publikováno v:
PLoS Pathogens, Vol 18, Iss 9, p e1010637 (2022)
Toxoplasma gondii is a ubiquitous intracellular protozoan parasite that establishes a life-long chronic infection largely restricted to the central nervous system (CNS). Constant immune pressure, notably IFN-γ-STAT1 signaling, is required for preven
Externí odkaz:
https://doaj.org/article/5015eb02b10c4b9fb1a39faaf13c541f
Autor:
Katherine M Still, Samantha J Batista, Carleigh A O'Brien, Oyebola O Oyesola, Simon P Früh, Lauren M Webb, Igor Smirnov, Michael A Kovacs, Maureen N Cowan, Nikolas W Hayes, Jeremy A Thompson, Elia D Tait Wojno, Tajie H Harris
Publikováno v:
PLoS Pathogens, Vol 16, Iss 10, p e1009027 (2020)
It is of great interest to understand how invading pathogens are sensed within the brain, a tissue with unique challenges to mounting an immune response. The eukaryotic parasite Toxoplasma gondii colonizes the brain of its hosts, and initiates robust
Externí odkaz:
https://doaj.org/article/15e74006523b4a4c8331d34646726ea9
Autor:
Michael A Kovacs, Maureen N Cowan, Isaac W Babcock, Lydia A Sibley, Katherine Still, Samantha J Batista, Sydney A Labuzan, Ish Sethi, Tajie H Harris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe86b45fed3a64113e3dadfb938ec33e
https://doi.org/10.7554/elife.80775.sa2
https://doi.org/10.7554/elife.80775.sa2
Autor:
Michael A. Kovacs, Maureen N. Cowan, Isaac W. Babcock, Lydia A. Sibley, Katherine Still, Samantha J. Batista, Sydney A. Labuzan, Ish Sethi, Tajie H. Harris
The discovery of meningeal lymphatic vessels that drain the central nervous system (CNS) has prompted new insights into how neuroinflammation develops. In this study, we examined how T cell responses against CNS-derived antigen develop in the context
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b246830831e62b4b9b3986c35632fb1
https://doi.org/10.1101/2022.06.02.494581
https://doi.org/10.1101/2022.06.02.494581
Autor:
Samantha J. Batista, Tajie H. Harris, David M. Johanson, Jeremy A. Thompson, Carleigh A. O’Brien, Katherine M. Still, John R. Lukens
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Microglia, resident immune cells of the CNS, are thought to defend against infections. Toxoplasma gondii is an opportunistic infection that can cause severe neurological disease. Here we report that during T. gondii infection a strong NF-κB and infl
Autor:
Michael Kovacs, Maureen N. Cowan, Katherine M. Still, Samantha J. Batista, Isaac Babcock, Lydia Sibley, Ish Sethi, Tajie H. Harris
Publikováno v:
The Journal of Immunology. 208:170.12-170.12
Toxoplasma gondii is an intracellular protozoan parasite that causes chronic brain infection in a wide range of mammalian hosts. Animal studies have demonstrated that continuous T cell recruitment to the brain is necessary for parasite control. Howev
Autor:
Carleigh A. O’Brien, Elia D. Tait Wojno, Igor Smirnov, Simon P. Früh, Nikolas William Hayes, Katherine M. Still, Michael A. Kovacs, Lauren M. Webb, Jeremy A. Thompson, Maureen N. Cowan, Tajie H. Harris, Samantha J. Batista, Oyebola O. Oyesola
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 16, Iss 10, p e1009027 (2020)
PLoS Pathogens, Vol 16, Iss 10, p e1009027 (2020)
It is of great interest to understand how invading pathogens are sensed within the brain, a tissue with unique challenges to mounting an immune response. The eukaryotic parasite Toxoplasma gondii colonizes the brain of its hosts, and initiates robust
Autor:
Michael Kovacs, Igor Smirnov, Samantha J. Batista, Maureen N. Cowan, Katherine M. Still, Ashley C. Bolte, Tajie H. Harris
Publikováno v:
The Journal of Immunology. 204:231.4-231.4
Toxoplasma gondii is an intracellular protozoan parasite that causes persistent infection in the central nervous system (CNS). Studies have demonstrated that continuous T cell recruitment to the brain is necessary for parasite control. However, the m
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 202(6)
Control of chronic CNS infection with the parasite Toxoplasma gondii requires ongoing T cell responses in the brain. Immunosuppressive cytokines are also important for preventing lethal immunopathology during chronic infection. To explore the loss of