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pro vyhledávání: '"Samantha J, Falk"'
Publikováno v:
Nature structural & molecular biology
The histone H3 variant, CENP-A, is incorporated into nucleosomes that mark centromere location. We recently reported that CENP-A confers an altered nucleosome shape relative to its counterparts containing conventional H3. Using a single molecule fluo
Autor:
Glennis A. Logsdon, Gregory D. Van Duyne, Kushol Gupta, Samantha J. Falk, Ben E. Black, Evan M. Smoak, Sergei A. Vinogradov, Lucie Y. Guo, Lars E.T. Jansen, Nikolina Sekulic, Michael A. Lampson, Tomoyasu Mani
Publikováno v:
Science. 348:699-703
Building stable centromeres Each of our chromosomes has a single centromere, seen as a constriction during cell division, which is required for accurate chromosome segregation to daughter cells. Falk et al. show that the special histone protein known
Autor:
Ben E. Black, Samantha J. Falk
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1819:313-321
The centromere is the locus that directs chromosomal inheritance at cell division. While centromeres in diverse eukaryotes are commonly found at sites of repetitive DNA, their location is epigenetically specified. The histone H3 variant CENP-A is the
Publikováno v:
Nucleic Acids Research
Structural dynamics of nucleic acid and protein is an important physical basis of their functions. These motions are often very difficult to synchronize and too fast to be clearly resolved with the currently available single molecule methods. Here we
Autor:
Samantha J, Falk, Lucie Y, Guo, Nikolina, Sekulic, Evan M, Smoak, Tomoyasu, Mani, Glennis A, Logsdon, Kushol, Gupta, Lars E T, Jansen, Gregory D, Van Duyne, Sergei A, Vinogradov, Michael A, Lampson, Ben E, Black
Publikováno v:
Science (New York, N.Y.). 348(6235)
Inheritance of each chromosome depends upon its centromere. A histone H3 variant, centromere protein A (CENP-A), is essential for epigenetically marking centromere location. We find that CENP-A is quantitatively retained at the centromere upon which
Autor:
Samantha J. Falk, Michael A. Lampson, Aiko Iwata-Otsubo, Takashi Akera, Karren Yang, Jennine M. Dawicki-McKenna, Beth A. Sullivan, Lukáš Chmátal, Ben E. Black, Richard M. Schultz
Publikováno v:
Current Biology. 27:2365-2373.e8
Female meiosis provides an opportunity for selfish genetic elements to violate Mendel's law of segregation by increasing the chance of segregating to the egg [1]. Centromeres and other repetitive sequences can drive in meiosis by cheating the segrega
Autor:
Samantha J, Falk, Ben E, Black
Publikováno v:
Biochimica et biophysica acta. 1819(3-4)
The centromere is the locus that directs chromosomal inheritance at cell division. While centromeres in diverse eukaryotes are commonly found at sites of repetitive DNA, their location is epigenetically specified. The histone H3 variant CENP-A is the