Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Samantha J, Boyd"'
Autor:
Samantha J. Boyd, Julia E. Rosenberger, Olga Dmitrenko, Joseph M. Fox, Yixin Xie, Andrew Jemas, Jessica E. Pigga
Publikováno v:
Angew Chem Int Ed Engl
trans -Cyclooctenes (TCOs) are essential partners for the fastest known bioorthogonal reactions, but current synthetic methods are limited by poor diastereoselectivity. Especially hard to access are hydrophilic TCOs with favorable physicochemical pro
Autor:
Christopher W. am Ende, Zhen Huang, Yinzhi Fang, Joshua C. Judkins, Joseph M. Fox, Douglas S. Johnson, Samantha J. Boyd, Katarina Rohlfing, Yixin Xie
Publikováno v:
Tetrahedron. 75:4307-4317
Conformationally strained trans-cyclooctenes (TCOs) engage in bioorthogonal reactions with tetrazines with second order rate constants that can exceed 106 M-1s-1. The goal of this study was to provide insight into the stability of TCO reagents and to
Autor:
Oshini Ekanayake, Christopher W. am Ende, Samuel L. Scinto, Uthpala Seneviratne, Samantha J. Boyd, Michael T. Taylor, Sharon Rozovsky, Jessica E. Pigga, Jun Liu, Joseph M. Fox
Publikováno v:
Journal of the American Chemical Society. 141:10932-10937
Sulfenylation (RSH → RSOH) is a post-translational protein modification associated with cellular mechanisms for signal transduction and the regulation of reactive oxygen species. Protein sulfenic acids are challenging to identify and study due to t
Autor:
Yinzhi, Fang, Joshua C, Judkins, Samantha J, Boyd, Christopher W, Am Ende, Katarina, Rohlfing, Zhen, Huang, Yixin, Xie, Douglas S, Johnson, Joseph M, Fox
Publikováno v:
Tetrahedron
Conformationally strained trans-cyclooctenes (TCOs) engage in bioorthogonal reactions with tetrazines with second order rate constants that can exceed 10(6) M(−1)s(−1). The goal of this study was to provide insight into the stability of TCO reage
Publikováno v:
Synthesis (Stuttg)
Functionalized trans-cyclooctenes are useful bioorthogonal reagents that are typically prepared using a flow photoisomerization method in which the product is captured by AgNO3 on silica gel. While this method is effective, the leaching of silver can
Autor:
Katarina Rohlfing, Joseph M. Fox, Samantha J. Boyd, Lisa A. Sawicki, Natalee J. Smith, Prathamesh M. Kharkar, April M. Kloxin
Publikováno v:
Organic & Biomolecular Chemistry. 16:2164-2169
A method of cysteine alkylation using cyclopropenyl ketones is described. Due to the significant release of cyclopropene strain energy, reactions of thiols with cyclopropenyl ketones are both fast and irreversible and give rise to stable conjugate ad
Autor:
Samuel L, Scinto, Oshini, Ekanayake, Uthpala, Seneviratne, Jessica E, Pigga, Samantha J, Boyd, Michael T, Taylor, Jun, Liu, Christopher W, Am Ende, Sharon, Rozovsky, Joseph M, Fox
Publikováno v:
J Am Chem Soc
Sulfenylation (RSH ->RSOH) is a posttranslational protein modification associated with cellular mechanisms for signal transduction and the regulation of reactive oxygen species. Protein sulfenic acids are challenging to identify and study due to thei
Autor:
Samuel L. Scinto, Samantha J. Boyd, Joseph M. Fox, Ronald Magboo, Jason W. Chin, Ryan A. Mehl, William D. Lambert, Stephen Wallace, Olga Dmitrenko
Publikováno v:
Organic & Biomolecular Chemistry
Lambert, W D, Scinto, S L, Dmitrenko, O, Boyd, S J, Magboo, R, Mehl, R A, Chin, J W, Fox, J M & Wallace, S 2017, ' Computationally guided discovery of a reactive, hydrophilic trans-5-oxocene dienophile for bioorthogonal labeling ', Organic & Biomolecular chemistry, vol. 15, no. 31, pp. 6640-6644 . https://doi.org/10.1039/c7ob01707c
Lambert, W D, Scinto, S L, Dmitrenko, O, Boyd, S J, Magboo, R, Mehl, R A, Chin, J W, Fox, J M & Wallace, S 2017, ' Computationally guided discovery of a reactive, hydrophilic trans-5-oxocene dienophile for bioorthogonal labeling ', Organic & Biomolecular chemistry, vol. 15, no. 31, pp. 6640-6644 . https://doi.org/10.1039/c7ob01707c
The use of organic chemistry principles and prediction techniques has enabled the development of new bioorthogonal reactions. As this "toolbox" expands to include new reaction manifolds and orthogonal reaction pairings, the continued development of e
Autor:
Ryan A. Mehl, Samuel L. Scinto, Jason W. Chin, Olga Dmitrenko, Ronald Magboo, William D. Lambert, Stephen Wallace, Samantha J. Boyd, Joseph M. Fox
Publikováno v:
Organic & Biomolecular Chemistry
The use of organic chemistry principles and prediction techniques has enabled the development of new bioorthogonal reactions.
The use of organic chemistry principles and prediction techniques has enabled the development of new bioorthogonal reac
The use of organic chemistry principles and prediction techniques has enabled the development of new bioorthogonal reac