Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Samantha J, Allen"'
Autor:
Anne M. Fourie, Xiaoli Cheng, Leon Chang, Carrie Greving, Xinyi Li, Beverly Knight, David Polidori, Aaron Patrick, Trpta Bains, Ruth Steele, Samantha J. Allen, Raymond J. Patch, Chengzao Sun, Sandeep Somani, Ashok Bhandari, David Liu, Keith Huie, Shu Li, Michael A. Rodriguez, Xiaohua Xue, Arun Kannan, Teddy Kosoglou, Jonathan P. Sherlock, Jennifer Towne, M. Claire Holland, Nishit B. Modi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The interleukin (IL)-23 pathway is a pathogenic driver in psoriasis, psoriatic arthritis, and inflammatory bowel disease. Currently, no oral therapeutics selectively target this pathway. JNJ-77242113 is a peptide targeting the IL-23 receptor
Externí odkaz:
https://doaj.org/article/a5c225b49e4844578be75fc534d1282c
Autor:
Aaron A. Thompson, Michael B. Harbut, Pei-Pei Kung, Nathan K. Karpowich, Jeffrey D. Branson, Joanna C. Grant, Deborah Hagan, Heather A. Pascual, Guoyun Bai, Reza Beheshti Zavareh, Heather R. Coate, Bernard C. Collins, Marjorie Côte, Christine F. Gelin, Kelly L. Damm-Ganamet, Hadi Gholami, Adam R. Huff, Luis Limon, Kevin J. Lumb, Puiying A. Mak, Kohki M. Nakafuku, Edmund V. Price, Amy Y. Shih, Mandana Tootoonchi, Nadeem A. Vellore, Jocelyn Wang, Na Wei, Jeannie Ziff, Scott B. Berger, James P. Edwards, Agnès Gardet, Siquan Sun, Jennifer E. Towne, Jennifer D. Venable, Zhicai Shi, Hariharan Venkatesan, Marie-Laure Rives, Sujata Sharma, Brock T. Shireman, Samantha J. Allen
Publikováno v:
Proceedings of the National Academy of Sciences. 120
NKG2D (natural-killer group 2, member D) is a homodimeric transmembrane receptor that plays an important role in NK, γδ + , and CD8 + T cell-mediated immune responses to environmental stressors such as viral or bacterial infections and oxidative st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4d48b50bde14ca39eb944d361970a99
https://doi.org/10.1073/pnas.2216342120
https://doi.org/10.1073/pnas.2216342120
Autor:
Jorge Vialard, Kelly Federowicz, Geoff Struble, Weixue Wang, Samantha J Allen, Daniel Jason Krosky, Annie Liu, Robyn L. Miller, Berthold Wroblowski, Kay Ahn, Laurence Anne Mevellec
Publikováno v:
Biochemistry. 60(41)
Achieving selectivity across the human kinome is a major hurdle in kinase inhibitor drug discovery. Assays using active, phosphorylated protein kinases bias hits toward poorly selective inhibitors that bind within the highly conserved adenosine triph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a434c7c0f939d41bacdd35042e3e1f1e
https://pubmed.ncbi.nlm.nih.gov/34608799
https://pubmed.ncbi.nlm.nih.gov/34608799
Autor:
Teena M Varghese, Michael F.A. Finley, Samantha J Allen, Paul L. Dudas, Jonathan E Schneeweis
Publikováno v:
SLAS discovery : advancing life sciences RD. 26(1)
Interleukin-23 (IL-23) is a key cytokine implicated in the pathogenesis of autoimmune disorders, including psoriasis and ulcerative colitis. Although targeted IL-23 antibody therapeutics are used clinically, there are no small-molecule therapeutics t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a31d677e00fe1099053c8119e05f938
https://pubmed.ncbi.nlm.nih.gov/32484379
https://pubmed.ncbi.nlm.nih.gov/32484379
Autor:
Samantha J, Allen, Kevin J, Lumb
Publikováno v:
Advances in protein chemistry and structural biology. 121
Protein-protein interactions are central to biology and provide opportunities to modulate disease with small-molecule or protein therapeutics. Recent developments in the understanding of the tractability of protein-protein interactions are discussed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::18dc9e25d067ab3e3bf0576f4d7b5f9f
https://pubmed.ncbi.nlm.nih.gov/32312425
https://pubmed.ncbi.nlm.nih.gov/32312425
Autor:
Piyali Chatterjee, Laura E Weaver, Karen M Doersch, Shelley E Kopriva, Valorie L Chiasson, Samantha J Allen, Ajay M Narayanan, Kristina J Young, Kathleen A Jones, Thomas J Kuehl, Brett M Mitchell
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41884 (2012)
Preeclampsia (PE) is a pregnancy-specific hypertensive syndrome characterized by excessive maternal immune system activation, inflammation, and endothelial dysfunction. Toll-like receptor (TLR) 3 activation by double-stranded RNA (dsRNA) and TLR7/8 a
Externí odkaz:
https://doaj.org/article/a4301ebdaa6e4c609d023b8d1682c41d
Autor:
Adam B Weinglass, Nicholas B Hastings, Bradley S Sherborne, Jennifer M. Johnston, Andrew D Howard, Maria Webb, Steven L. Colletti, Clemens Vonrhein, Kevin J. Lumb, Srivanya Tummala, Frank K Brown, Jennifer Hadix, Hubert Josien, Stephen M. Soisson, Guo Yan, Harry R. Chobanian, John Wang, Michael W. Miller, Brande Thomas-Fowlkes, Dawn L. Hall, Jeffrey D. Hermes, Thu Ho, Barbara Pio, Payal R. Sheth, Sujata Sharma, Maria Kornienko, Samantha J Allen, Sangita B. Patel, Jerry Di Salvo, Sarah Souza, Gérard Bricogne, Christopher W Plummer, Jun Lu, Noel Byrne
Publikováno v:
Nature Structural & Molecular Biology. 24:570-577
Clinical studies indicate that partial agonists of the G-protein-coupled, free fatty acid receptor 1 GPR40 enhance glucose-dependent insulin secretion and represent a potential mechanism for the treatment of type 2 diabetes mellitus. Full allosteric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db4bc0224021f59b552cc8f44381dfe9
https://doi.org/10.1038/nsmb.3417
https://doi.org/10.1038/nsmb.3417
Autor:
Kevin J. Lumb, Samantha J Allen
Publikováno v:
Advances in Protein Chemistry and Structural Biology ISBN: 9780128168462
Protein-protein interactions are central to biology and provide opportunities to modulate disease with small-molecule or protein therapeutics. Recent developments in the understanding of the tractability of protein-protein interactions are discussed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecdecf790171ac6068f25f58c9972cd1
https://doi.org/10.1016/bs.apcsb.2019.12.006
https://doi.org/10.1016/bs.apcsb.2019.12.006
Publikováno v:
Journal of surgical education. 77(3)
Objectives The ability to assess a trainee's technical skill in a manner that maintains patient safety is critical to resident education. To do so, senior plastic surgery educators frequently ask residents to draw their proposed operation, presuming
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd583868dff972373575bb48da4b162
https://pubmed.ncbi.nlm.nih.gov/31954663
https://pubmed.ncbi.nlm.nih.gov/31954663
Autor:
Nathaniel L. Elsen, Zangwei Xu, Peter J. Dandliker, Peter Saradjian, Keith W. Rickert, Berengere Sauvagnat, Nadya Smotrov, Dawn L. Hall, Elliott B. Nickbarg, Yiping Chen, Sujata Sharma, Kevin J. Lumb, Maria Kornienko, Noel Byrne, Chad Chamberlin, Christine Andrews, Samantha J Allen, Ilona Kariv, Jennifer M. Shipman, Patrick J. Curran, Kevin G. Coleman, Beutel Bruce A, Rachael E. Ford, Victoria Kutilek, Andrew Hashke, Rafael Fernandez, Tianxiao Sun, Matthew Richards, Ryan Boinay
Publikováno v:
SLAS Discovery. 21:608-619
The primary objective of early drug discovery is to associate druggable target space with a desired phenotype. The inability to efficiently associate these often leads to failure early in the drug discovery process. In this proof-of-concept study, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::321009edd98ca17a57d26928e293e5e3
https://doi.org/10.1177/1087057116637353
https://doi.org/10.1177/1087057116637353