Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Samantha Hover"'
Autor:
Samantha Hover, Frank W. Charlton, Jan Hellert, Jessica J. Swanson, Jamel Mankouri, John N. Barr, Juan Fontana
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Following endocytosis, enveloped viruses employ the changing environment of maturing endosomes as cues to promote endosomal escape, a process often mediated by viral glycoproteins. We previously showed that both high [K+] and low pH promote
Externí odkaz:
https://doaj.org/article/89f71ba3dc2a4843a816c001509db607
Autor:
Francis R. Hopkins, Beatriz Álvarez-Rodríguez, George R. Heath, Kyriakoulla Panayi, Samantha Hover, Thomas A. Edwards, John N. Barr, Juan Fontana
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT The Bunyavirales order is the largest group of negative-sense RNA viruses, containing many lethal human pathogens for which approved anti-infective measures are not available. The bunyavirus genome consists of multiple negative-sense RNA seg
Externí odkaz:
https://doaj.org/article/ca0a31a995f34aa189f26897e51a0d34
Autor:
Frank W. Charlton, Hayley M. Pearson, Samantha Hover, Jon D. Lippiat, Juan Fontana, John N. Barr, Jamel Mankouri
Publikováno v:
Viruses, Vol 12, Iss 8, p 844 (2020)
Ion channels play key roles in almost all facets of cellular physiology and have emerged as key host cell factors for a multitude of viral infections. A catalogue of ion channel-blocking drugs have been shown to possess antiviral activity, some of wh
Externí odkaz:
https://doaj.org/article/e7a4812d957f42fca080e4a7bce92b38
Bunyavirus requirement for endosomal K+ reveals new roles of cellular ion channels during infection.
Autor:
Samantha Hover, Becky Foster, Juan Fontana, Alain Kohl, Steve A N Goldstein, John N Barr, Jamel Mankouri
Publikováno v:
PLoS Pathogens, Vol 14, Iss 1, p e1006845 (2018)
In order to multiply and cause disease a virus must transport its genome from outside the cell into the cytosol, most commonly achieved through the endocytic network. Endosomes transport virus particles to specific cellular destinations and viruses e
Externí odkaz:
https://doaj.org/article/4507de61e0c8440783ae8ed163af20ee
Following internalisation, viruses employ the changing environment of maturing endosomes as cues to promote endosomal escape, a process mediated by viral glycoproteins. Specifically, we previously showed that both high [K+] and low pH promote entry o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fc3cabb4501af2b135a079194f5f3b1
https://doi.org/10.1101/2022.08.11.503604
https://doi.org/10.1101/2022.08.11.503604
Autor:
Juan Fontana, Francis R. Hopkins, Beatriz Álvarez-Rodríguez, George R. Heath, Kyriakoulla Panayi, Thomas A. Edwards, John N. Barr, Samantha Hover
The Bunyavirales order of RNA viruses comprises emerging pathogens for which approved preventative or therapeutic measures for human use are not available. The genome of all Bunyavirales consists of negative-sense RNA segments wrapped by the virus-en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef70a44f3ad79bf3171414a4ec5e7f76
https://doi.org/10.1101/2021.10.27.466080
https://doi.org/10.1101/2021.10.27.466080
Autor:
Jack Fuller, Juan Fontana, Jamel Mankouri, Frank W. Charlton, Roger Hewson, Samantha Hover, John N. Barr
Publikováno v:
J Biol Chem
The Bunyavirales order of segmented negative sense RNA viruses includes over 500 isolates that infect insects, animals, and plants, and are often associated with severe and fatal disease in humans. To multiply and cause disease, bunyaviruses must tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c4d3cd0bac25dd6302d77634c20facb
https://doi.org/10.1074/jbc.ra119.007618
https://doi.org/10.1074/jbc.ra119.007618
Autor:
Hans-Gerd Fieguth, John N. Barr, Olga Danov, Hayley Pearson, Martin Stacey, Christina Hesse, Ludwig Wilkens, Jamel Mankouri, Eleanor J. A. A. Todd, Jonathan D. Lippiat, Adrian Whitehouse, Samantha Hover, Mareike Ahrends
Publikováno v:
Thorax
IntroductionHuman respiratory syncytial virus (HRSV) is a common cause of respiratory tract infections (RTIs) globally and is one of the most fatal infectious diseases for infants in developing countries. Of those infected, 25%–40% aged ≤1 year d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b98d09f0d63fe506da99f94a75c043f9
https://publica.fraunhofer.de/handle/publica/269251
https://publica.fraunhofer.de/handle/publica/269251
Autor:
Jon D. Lippiat, Hayley Pearson, Jamel Mankouri, John N. Barr, Samantha Hover, Juan Fontana, Frank W. Charlton
Publikováno v:
Viruses, Vol 12, Iss 844, p 844 (2020)
Viruses
Viruses
Ion channels play key roles in almost all facets of cellular physiology and have emerged as key host cell factors for a multitude of viral infections. A catalogue of ion channel-blocking drugs have been shown to possess antiviral activity, some of wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d02e6744ceb93a058097aa64bb4432b6
Autor:
Jamel Mankouri, Juan Fontana, Darren C. Tomlinson, Samantha Hover, Oliver Desbki-Antoniak, Christian Tiede
Publikováno v:
Access Microbiology. 1
Influenza virus is the causative agent of the ‘flu’. According to the World Health Organisation, Influenza causes up to 5 million cases of severe flu and 500 000 deaths annually. To release its genome inside the cell and start an infection, Influ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::faaef19d413e9c4a2d7170736a6b165a
https://doi.org/10.1099/acmi.ac2019.po0546
https://doi.org/10.1099/acmi.ac2019.po0546