Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Samantha Grosslight"'
Autor:
Jordan J. Dotson, Lucy van Dijk, Jacob C. Timmerman, Samantha Grosslight, Richard C. Walroth, Francis Gosselin, Kurt Püntener, Kyle A. Mack, Matthew S. Sigman
Publikováno v:
J Am Chem Soc
Optimization of the catalyst structure to simultaneously improve multiple reaction objectives (e.g., yield, enantioselectivity, and regioselectivity) remains a formidable challenge. Herein, we describe a machine learning workflow for the multi-object
Autor:
Jie Xu, Samantha Grosslight, Kyle A. Mack, Sierra C. Nguyen, Kyle Clagg, Ngiap-Kie Lim, Jacob C. Timmerman, Jeff Shen, Nicholas A. White, Lauren E. Sirois, Chong Han, Haiming Zhang, Matthew S. Sigman, Francis Gosselin
Publikováno v:
Journal of the American Chemical Society. 144(45)
An efficient asymmetric synthesis of a potent KRAS G12C covalent inhibitor, GDC-6036 (
Autor:
Jordan Dotson, Lucy van Dijk, Jacob Timmerman, Samantha Grosslight, Richard Walroth, Kurt Püntener, Francis Gosselin, Kyle Mack, Matthew Sigman
Optimization of catalyst structure to simultaneously improve multiple reaction objectives (e.g., yield, enantio-, and regioselectivity) remains a formidable challenge. Herein, we describe a machine learning workflow for the multi-objective optimizati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96e33cbc97b290f6660118f1289b4ee5
https://doi.org/10.26434/chemrxiv-2022-qqxd1
https://doi.org/10.26434/chemrxiv-2022-qqxd1
Autor:
Niccolò Bartalucci, Antonio Togni, Paul C. J. Kamer, Tobias Gensch, Claas Schünemann, Matthew S. Sigman, Samantha Grosslight, Bernd H. Müller, Benson J. Jelier, Jordan De Jesus Silva, Christophe Copéret
A synthetic method for the palladium-catalyzed cyanation of aryl boronic acids using bench stable and non-toxic N-cyanosuccinimide has been developed. High-throughput experimentation facilitated the screen of 90 different ligands and the resultant st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a2a25e45dd9be85b6d65ccc95c9d7d4
https://doi.org/10.33774/chemrxiv-2021-h1596
https://doi.org/10.33774/chemrxiv-2021-h1596
Autor:
Alexey Fedorov, Jordan De Jesus Silva, Christophe Copéret, Samantha Grosslight, Matthew S. Sigman, Marco A. B. Ferreira
Publikováno v:
Journal of the American Chemical Society, 141 (27)
High-throughput experimentation and multivariate modeling allow identification of noncovalent interactions (NCIs) in monoaryloxy-pyrrolide Mo imido alkylidene metathesis catalysts prepared in situ as a key driver for high activity in a representative
Autor:
Jordan De Jesus Silva, Antonio Togni, Benson J. Jelier, Claas Schünemann, Paul C. J. Kamer, Christophe Copéret, Bernd H. Müller, Matthew S. Sigman, Niccolò Bartalucci, Samantha Grosslight, Tobias Gensch
Publikováno v:
Helvetica Chimica Acta, 104 (12)
A synthetic method for the palladium-catalyzed cyanation of aryl boronic acids using bench stable and non-toxic N-cyanosuccinimide has been developed. High-throughput experimentation facilitated the screen of 90 different ligands and the resultant st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7da251ca9a696ccc9095841f782da4d7
Autor:
Briana J. Mulligan, Hope Spargo, Silvana S. Saad, James R. Vyvyan, Patrick M.M. Shelton, Samantha Grosslight
Publikováno v:
Tetrahedron. 76:131500
The guaipyridine alkaloids cananodine, rupestine D and rupestine G were synthesized in six steps or less from readily available 3-(allyloxy)-2-(bromomethyl)-6-methylpyridine. Key steps in the synthesis include an enolate alkylation of the aforementio