Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Samantha Graffam"'
Autor:
Sonia M Vallabh, Jacquelyn Stathopoulos, Samantha Graffam, Deborah E Cabin, Rose Pitstick, Tyler Caron, George A. Carlson, Jeffrey B. Carroll, Rhonda O’Keefe, Hien T Zhao, Jiyan Ma, Holly B. Kordasiewicz, Jae Beom Kim, Debbie McKenzie, Jason Le, Michael P Kavanaugh, Eric Vallabh Minikel, Holger Wille, Jasna Kriz, Stuart L. Schreiber, Jill O'Moore, Katsumi Doh-ura, Matthew Beck, Judd M. Aiken
Publikováno v:
Nucleic Acids Research
Lowering of prion protein (PrP) expression in the brain is a genetically validated therapeutic hypothesis in prion disease. We recently showed that antisense oligonucleotide (ASO)-mediated PrP suppression extends survival and delays disease onset in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a83f52ed969a327263d04ee6f67bc11
https://doi.org/10.1101/2020.03.27.011940
https://doi.org/10.1101/2020.03.27.011940
Autor:
Samantha Graffam, Stuart L. Schreiber, Holly Kordasiewicz, Hien T Zhao, Brent Race, Eric E. Swayze, Byron Caughey, Jason Le, Lori L. Lubke, Katie Williams, Rhonda O’Keefe, Jacquelyn Stathopoulos, Andrew G. Reidenbach, Gregory J. Raymond, Deborah E Cabin, Tyler Caron, Eric Vallabh Minikel, Curt Mazur, Allison Kraus, Lynne D. Raymond, Jeffrey B. Carroll, Sonia M Vallabh
Publikováno v:
JCI Insight
Prion disease is a fatal, incurable neurodegenerative disease of humans and other mammals caused by conversion of cellular prion protein (PrPC) into a self-propagating neurotoxic conformer (prions; PrPSc). Strong genetic proofs of concept support low
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2318f227c770d1c1bfab0eed97f7ddab
http://europepmc.org/articles/PMC6777807
http://europepmc.org/articles/PMC6777807
