Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Samantha F. Moore"'
Autor:
Andrei-Emil Constantinescu, Caroline J. Bull, Lucy J. Goudswaard, Jie Zheng, Benjamin Elsworth, Nicholas J. Timpson, Samantha F. Moore, Ingeborg Hers, Emma E. Vincent
Publikováno v:
BMC Medical Genomics, Vol 16, Iss 1, Pp 1-16 (2023)
Abstract Deep vein thrombosis (DVT) is the formation of a blood clot in a deep vein. DVT can lead to a venous thromboembolism (VTE), the combined term for DVT and pulmonary embolism, a leading cause of death and disability worldwide. Despite the prev
Externí odkaz:
https://doaj.org/article/46d63e3cfff945c29f75b349c795307b
Autor:
Haonan Liu, Molly L. Jackson, Lucy J. Goudswaard, Samantha F. Moore, James L. Hutchinson, Ingeborg Hers
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Sphingosine 1-phosphate (S1P) is a bioactive signalling sphingolipid that is increased in diseases such as obesity and diabetes. S1P can modulate platelet function, however the direction of effect and S1P receptors (S1PRs) involved are contr
Externí odkaz:
https://doaj.org/article/54f3d48ee6ef49698d91107aee9c25b1
Autor:
Samantha F. Moore, Ejaife O. Agbani, Andreas Wersäll, Alastair W. Poole, Chris M. Williams, Xiaojuan Zhao, Yong Li, James L. Hutchinson, Roger W. Hunter, Ingeborg Hers
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10656 (2021)
One of the mechanisms by which PI3 kinase can regulate platelet function is through phosphorylation of downstream substrates, including glycogen synthase kinase-3 (GSK3)α and GSK3β. Platelet activation results in the phosphorylation of an N-termina
Externí odkaz:
https://doaj.org/article/61cd90332d4243aa9ac67f91886d4c35
Autor:
Justin S. Trory, Attila Munkacsi, Kamila M. Śledź, Jordan Vautrinot, Lucy J. Goudswaard, Molly L. Jackson, Kate J. Heesom, Samantha F. Moore, Alastair W. Poole, Behnam Nabet, Varinder K. Aggarwal, Ingeborg Hers
Publikováno v:
Blood Advances. 7:1692-1696
Autor:
Justin S. Trory, Attila Munkacsi, Kamila M. Śledź, Lucy J. Goudswaard, Kate J. Heesom, Samantha F. Moore, Behnam Nabet, Varinder K. Aggarwal, Ingeborg Hers
The tyrosine kinase BTK plays an important role in platelet function downstream of GPVI and CLEC2 receptors and has been proposed as a novel target to prevent thrombosis in patients that are at increased risk. However, current clinically approved BTK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e617c468b2532e8a99fd83249e2f129
https://doi.org/10.1101/2022.05.30.493973
https://doi.org/10.1101/2022.05.30.493973
Autor:
Molly L Jackson, Haonan Liu, Lucy J Goudswaard, James L Hutchinson, Samantha F. Moore, Ingeborg Hers
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Liu, H, Jackson, M L, Goudswaard, L J, Moore, S F, Hutchinson, J L & Hers, I 2021, ' Sphingosine-1-phosphate modulates PAR1-mediated human platelet activation in a concentration-dependent biphasic manner ', Scientific Reports, vol. 11, no. 1, 15308 . https://doi.org/10.1038/s41598-021-94052-4
Scientific Reports
Liu, H, Jackson, M L, Goudswaard, L J, Moore, S F, Hutchinson, J L & Hers, I 2021, ' Sphingosine-1-phosphate modulates PAR1-mediated human platelet activation in a concentration-dependent biphasic manner ', Scientific Reports, vol. 11, no. 1, 15308 . https://doi.org/10.1038/s41598-021-94052-4
Scientific Reports
Sphingosine 1-phosphate (S1P) is a bioactive signalling sphingolipid that is increased in diseases such as obesity and diabetes. S1P can modulate platelet function, however the direction of effect and S1P receptors (S1PRs) involved are controversial.
Autor:
Alastair W. Poole, Ingeborg Hers, Yong Li, Roger W. Hunter, Samantha F. Moore, James L Hutchinson, Christopher Williams, Xiaojuan Zhao, E.O. Agbani, Andreas Wersäll
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 10656, p 10656 (2021)
Volume 22
Issue 19
Moore, S F, Agbani, E O, Wersall, J A, Poole, A W, Williams, C M, Zhao, X, Li, Y, Hutchinson, J L, Hunter, R W & Hers, I 2021, ' Opposing roles of gsk3α and gsk3β phosphorylation in platelet function and thrombosis ', International Journal of Molecular Sciences, vol. 22, no. 19, 10656, pp. 10656 . https://doi.org/10.3390/ijms221910656
International Journal of Molecular Sciences, Vol 22, Iss 10656, p 10656 (2021)
Volume 22
Issue 19
Moore, S F, Agbani, E O, Wersall, J A, Poole, A W, Williams, C M, Zhao, X, Li, Y, Hutchinson, J L, Hunter, R W & Hers, I 2021, ' Opposing roles of gsk3α and gsk3β phosphorylation in platelet function and thrombosis ', International Journal of Molecular Sciences, vol. 22, no. 19, 10656, pp. 10656 . https://doi.org/10.3390/ijms221910656
One of the mechanisms by which PI3 kinase can regulate platelet function is through phosphorylation of downstream substrates, including glycogen synthase kinase-3 (GSK3)α and GSK3β. Platelet activation results in the phosphorylation of an N-termina
Autor:
Willem H. Ouwehand, Sofia Papadia, Samantha F. Moore, Keith Gomez, Maria Luisa Lozano, Claire Burney, Kate Downes, Chantal Thys, Neil V. Morgan, José Rivera, Kathleen Freson, Cheng Hock Toh, Michael Laffan, Sarah K Westbury, Wendy N. Erber, Samya Obaji, Carly Kempster, Andrew D Mumford, Teresa Sevivas
Publikováno v:
2018, ' Phenotype description and response to thrombopoietin receptor agonist in DIAPH1-related disorder ', Blood Advances, vol. 2, no. 18, pp. 2341-2346 . https://doi.org/10.1182/bloodadvances.2018020370
The heritable thrombocytopenias (HTs) are genetically heterogeneous rare disorders in whichreduced circulating platelet levels may be associated with nonhematological features. Amongrecently discovered HTs, DIAPH1-related disorder (D-RD; OMIM #124900
Autor:
Alastair W. Poole, Ingeborg Hers, Xiaojuan Zhao, Samantha F. Moore, Shahida Mallah, Stuart J. Mundell, James L Hutchinson
SHARPIN (Src homology 3 and multiple ankyrin repeat domains protein (SHANK)- associated RH domain-interacting protein) as part of the linear ubiquitin chain assembly complex (LUBAC) catalyses the addition of linear (Met1-linked) ubiquitin chains to s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cedf1079a254648e07da95734ccedc0
https://doi.org/10.1101/2021.01.13.426403
https://doi.org/10.1101/2021.01.13.426403
Autor:
Samantha F. Moore, Marieangela C. Wilson, Yiliang Jiang, Ingeborg Hers, Tom N. Durrant, Asha L. Bayliss, Elizabeth W. Aitken, Kate J. Heesom
Publikováno v:
Durrant, T N, Moore, S F, Bayliss, A L, Jiang, Y, Aitken, E W, Wilson, M C, Heesom, K J & Hers, I 2020, ' Identification of PtdIns(3,4)P 2 effectors in human platelets using quantitative proteomics ', Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, vol. 1865, no. 2, 158575 . https://doi.org/10.1016/j.bbalip.2019.158575
After decades in PtdIns(3,4,5)P3's shadow, PtdIns(3,4)P2 has now emerged as a bona fide regulator of important cellular events, including endocytosis and cell migration. New understanding of PtdIns(3,4)P2's cellular roles has been possible via novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f83e5d8139f11a6df637f20ec07d061
https://hdl.handle.net/1983/05093447-5f5c-4e41-bce6-b48c02affa3e
https://hdl.handle.net/1983/05093447-5f5c-4e41-bce6-b48c02affa3e