Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Samantha E. Yohn"'
Publikováno v:
Frontiers in Psychiatry, Vol 15 (2024)
Cognitive impairment is a core symptom of schizophrenia and a major determinant of poor long-term functional outcomes. Despite considerable efforts, we do not yet have any approved pharmacological treatments for cognitive impairment associated with s
Externí odkaz:
https://doaj.org/article/98c84786a3e24a8ea9a6f3a1a70a40c1
Publikováno v:
Trends in Pharmacological Sciences. 43:1098-1112
Modern interest in muscarinic acetylcholine receptor (mAChR) activators for schizophrenia began in the 1990s when xanomeline, an M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63266f26f1cb0b097ede00179965f79c
https://doi.org/10.1016/j.tips.2022.09.006
https://doi.org/10.1016/j.tips.2022.09.006
Publikováno v:
Biological Psychiatry. 93:S167-S168
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63920c0eddb3152fafc769cf8b5e69fa
https://doi.org/10.1016/j.biopsych.2023.02.423
https://doi.org/10.1016/j.biopsych.2023.02.423
Publikováno v:
The American journal of psychiatry. 179(9)
Schizophrenia remains a challenging disease to treat effectively with current antipsychotic medications due to their limited efficacy across the entire spectrum of core symptoms as well as their often burdensome side-effect profiles and poor tolerabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44238deab258d46533d3956a5ff2fbb8
https://pubmed.ncbi.nlm.nih.gov/35758639
https://pubmed.ncbi.nlm.nih.gov/35758639
Publikováno v:
Biological Psychiatry. 91:S286-S287
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38b0e703b211e88ba21dd8d5fa26efd4
https://doi.org/10.1016/j.biopsych.2022.02.726
https://doi.org/10.1016/j.biopsych.2022.02.726
Autor:
Kristen Gilliland, Anna L. Blobaum, Samantha E. Yohn, P. Jeffrey Conn, Craig W. Lindsley, Michael L. Schulte, Alice L. Rodriguez, Colleen M. Niswender, Mathew T. Loch, Yousuke Yamada
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:2670-2674
This letter describes the further optimization of a series of mGlu3 NAMs based on an N-aryl phenoxyethoxy pyridinone core. A multidimensional optimization campaign, with focused matrix libraries, quickly established challenging SAR, enantiospecific a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::438cabb90f97081c793abe0097c3b955
https://doi.org/10.1016/j.bmcl.2019.07.030
https://doi.org/10.1016/j.bmcl.2019.07.030
Autor:
Alice L. Rodriguez, P. Jeffrey Conn, Allison R. Gregro, Michael Bubser, Mark E. Dugan, Colleen M. Niswender, Leah C. Konkol, Michael W. Wood, Darren W. Engers, Craig W. Lindsley, Jeanette L. Bertron, Bruce J. Melancon, Sean R. Bollinger, Thomas M. Bridges, Samantha E. Yohn, Vincent B. Luscombe, Andrew S. Felts, Michael R. Wood, Carrie K. Jones, Nicholas J. Brandon, Katrina A. Bollinger
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:1714-1718
This letter describes progress towards an M4 PAM preclinical candidate that resulted in the discovery of VU6005806/AZN-00016130. While the thieno[2,3-c]pyridazine core has been a consistent feature of key M4 PAMs, no work had previously been reported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49ea6005ae21bf03b498cfa06332687e
https://doi.org/10.1016/j.bmcl.2019.05.026
https://doi.org/10.1016/j.bmcl.2019.05.026
Publikováno v:
ACS Chem Neurosci
Accumulated data from clinical and preclinical studies suggest that in drug addiction and states of overeating, such as obesity and binge eating disorder (BED), there is an imbalance in circuits that are critical for motivation, reward saliency, exec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f58b3e14c21c8a65de1922c59dcd7267
https://doi.org/10.1021/acschemneuro.8b00601
https://doi.org/10.1021/acschemneuro.8b00601
Autor:
Patrick A Randall, Christie A Lee, Eric J Nunes, Samantha E Yohn, Victoria Nowak, Bilal Khan, Priya Shah, Saagar Pandit, V Kiran Vemuri, Alex Makriyannis, Younis Baqi, Christa E Müller, Merce Correa, John D Salamone
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99320 (2014)
Behavioral activation is a fundamental feature of motivation, and organisms frequently make effort-related decisions based upon evaluations of reinforcement value and response costs. Furthermore, people with major depression and other disorders often
Externí odkaz:
https://doaj.org/article/0407af54d2fd4e45885f6af06f13be41
Autor:
David L. McKinzie, Christian C. Felder, Kathryn Fischer, Timothy Meyer, Samantha E. Yohn, Michael Popiolek, Steven M. Paul
Publikováno v:
Biological Psychiatry. 91:S332
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::117b942d7320917d795693e0d03ccfd4
https://doi.org/10.1016/j.biopsych.2022.02.836
https://doi.org/10.1016/j.biopsych.2022.02.836