Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Samantha E. Pace"'
Autor:
Neal Whitaker, Samantha E. Pace, Kimberly Merritt, Madeleine Tadros, Mehrnaz Khossravi, Smeet Deshmukh, Yuan Cheng, Sangeeta B. Joshi, David B. Volkin, Prajnaparamita Dhar
Publikováno v:
Journal of pharmaceutical sciences. 111(11)
Therapeutic proteins are subjected to a variety of stresses during manufacturing, storage or administration, that often lead to undesired protein aggregation and particle formation. Ultrafiltration-diafiltration (UF-DF) processing of monoclonal antib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd9920a27749227986430ba3736adb41
https://pubmed.ncbi.nlm.nih.gov/35940242
https://pubmed.ncbi.nlm.nih.gov/35940242
Autor:
Brittney J. Mills, Samantha E. Pace, David D. Weis, Reza Esfandiary, David B. Volkin, C. Russell Middaugh, Ronald T. Toth, Sangeeta B. Joshi
Publikováno v:
Journal of Pharmaceutical Sciences. 107:1009-1019
Antibodies are molecules that exhibit diverse conformational changes on different timescales, and there is ongoing interest to better understand the relationship between antibody conformational dynamics and storage stability. Physical stability data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::951be3f3caf27c3149f06ce21d414bd6
https://doi.org/10.1016/j.xphs.2017.12.009
https://doi.org/10.1016/j.xphs.2017.12.009
Autor:
Mark T. Fisher, C.R. Middaugh, Samantha E. Pace, Reza Esfandiary, Sangeeta B. Joshi, Steven M. Bishop, David B. Volkin, Robert Stadelman
Publikováno v:
Journal of Pharmaceutical Sciences. 107:559-570
An automated method using biotinylated GroEL-streptavidin biosensors with biolayer interferometry (GroEL-BLI) was evaluated to detect the formation of transiently formed, preaggregate species in various pharmaceutically relevant monoclonal antibody (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16eb4ac3f94e47d3cfffe81363e31313
https://doi.org/10.1016/j.xphs.2017.10.010
https://doi.org/10.1016/j.xphs.2017.10.010
Autor:
C. Russell Middaugh, Jian Xiong, Samantha E. Pace, David B. Volkin, Sangeeta B. Joshi, Neal Whitaker, Vineet Kumar
Publikováno v:
Journal of Pharmaceutical Sciences. 106:3230-3241
High protein concentration formulations are required for low-volume administration of therapeutic antibodies targeted for subcutaneous, self-administration by patients. Ultra-high concentrations (≥150 mg/mL) can lead to dramatically increased solut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e7baa3bb4f90e31142ea470cddc3e0f
https://doi.org/10.1016/j.xphs.2017.06.017
https://doi.org/10.1016/j.xphs.2017.06.017