Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Samantha Drennan"'
Autor:
Francesco Forconi, Freda K. Stevenson, Graham Packham, Andrew J. Steele, Livio Trentin, Peter W. Johnson, Ian Tracy, Annalisa D'Avola, Giorgia Chiodin, Samantha Drennan
Purpose:In chronic lymphocytic leukemia (CLL), disease progression associates with surface IgM (sIgM) levels and signaling capacity. These are variably downmodulated in vivo and recover in vitro, suggesting a reversible influence of tissue-located an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d48044b2377dccbafbdf0dcea6600a8
https://doi.org/10.1158/1078-0432.c.6528189
https://doi.org/10.1158/1078-0432.c.6528189
Autor:
Francesco Forconi, Freda K. Stevenson, Graham Packham, Andrew J. Steele, Livio Trentin, Peter W. Johnson, Ian Tracy, Annalisa D'Avola, Giorgia Chiodin, Samantha Drennan
Supplementary Tables S1-S2 and Figures S1-S4 with legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37476898a6b2f9de79ed9274e267d98d
https://doi.org/10.1158/1078-0432.22472301
https://doi.org/10.1158/1078-0432.22472301
Autor:
Heather Long, Emily Tye, Elizabeth Jinks, Tracey Haigh, Baksho Kaul, Prashant Patel, Helen Parry, Maddy Newby, Max Crispin, Nayandeep Kaur, Paul Moss, Samantha Drennan, Graham Taylor
CD4 + T-cells are essential for protection against viruses including SARS-CoV-2. Mutations in SARS-CoV-2 variants of concern (VOC) can enhance infectivity and reduce antibody recognition. CD4 + T-cell sensitivity to mutations is less well understood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::030d67622b87f31e473010520034b7bd
https://doi.org/10.21203/rs.3.rs-1501801/v1
https://doi.org/10.21203/rs.3.rs-1501801/v1
Autor:
Giorgia Chiodin, Samantha Drennan, Enrica A. Martino, Laura Ondrisova, Isla Henderson, Luis del Rio, Ian Tracy, Annalisa D’Avola, Helen Parker, Silvia Bonfiglio, Lydia Scarfò, Lesley-Ann Sutton, Jonathan C. Strefford, Jade Forster, Oliver Brake, Kathleen N. Potter, Benjamin Sale, Stuart Lanham, Marek Mraz, Paolo Ghia, Freda K. Stevenson, Francesco Forconi
Publikováno v:
Blood advances. 6(18)
Chronic lymphocytic leukemia (CLL) cells have variably low surface IgM (sIgM) levels/signaling capacity, influenced by chronic antigen engagement at tissue sites. Within these low levels, CLL with relatively high sIgM (CLLhigh) progresses more rapidl
Autor:
Shankara Paneesha, Francesco Forconi, Helen Parry, Surita Dalal, Jingwen Mao, Peter Hillmen, Nicholas J. Davies, Duncan M. Baird, Paul Evans, Angelo Agathanggelou, Talha Munir, Tatjana Stankovic, A. Malcolm R. Taylor, Anshita Goel, Rhiannon E. Jones, Andrew D Beggs, Jean-Baptiste Cazier, Marwan Kwok, Archana Sharma-Oates, Naheema S. Gordon, Paul Moreton, Grigorios Papatzikas, Samantha Drennan, Andy C. Rawstron, Robert Hollows, Paul Moss, Edward Smith, Guy Pratt, Mayumi Hamada, Ceri E. Oldreive
Publikováno v:
Blood. 135(6)
Spontaneous regression is a recognized phenomenon in chronic lymphocytic leukemia (CLL) but its biological basis remains unknown. We undertook a detailed investigation of the biological and clinical features of 20 spontaneous CLL regression cases inc
Autor:
Graham Packham, Francesco Forconi, Livio Trentin, Peter Johnson, Annalisa D'Avola, Ian Tracy, Giorgia Chiodin, Freda K. Stevenson, Samantha Drennan, Andrew J. Steele
Purpose: In chronic lymphocytic leukemia (CLL), disease progression associates with surface IgM (sIgM) levels and signaling capacity. These are variably downmodulated in vivo and recover in vitro, suggesting a reversible influence of tissue-located a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cda0f49d1d4e6fabccbeb83b2f559a60
https://eprints.soton.ac.uk/425691/
https://eprints.soton.ac.uk/425691/
Autor:
Isla Henderson, Laura Ondrisova, Ian Tracy, Marek Mráz, David Dutton, Andrew J. Steele, Peter Johnson, Annalisa D'Avola, Graham Packham, Andrew S Duncombe, Giorgia Chiodin, Lesley-Ann Sutton, Jonathan C. Strefford, Matthew J. J. Rose-Zerilli, Silvia Bonfiglio, Samantha Drennan, Christina Pitsillidou, Helen Parker, Paolo Ghia, Lydia Scarfò, Enrica Antonia Martino, Freda K. Stevenson, Francesco Forconi
Publikováno v:
Blood. 134:1752-1752
The circulating tumor cells of chronic lymphocytic leukemia (CLL) are characterized by variably low surface IgM (sIgM) levels and signaling capacity, consequent to stimulation by tissue-based antigen. The variability is evident in both CLL subsets wi
Autor:
Christoph Plass, Annalisa D'Avola, Andrew J. Steele, Samantha Drennan, Graham Packham, Marta Larrayoz, Freda K. Stevenson, Isla Henderson, Laura Chiecchio, Matthew J. J. Rose-Zerilli, Peter M. W. Johnson, Ian Tracy, Christopher C. Oakes, Jonathan C. Strefford, Francesco Forconi
Chronic lymphocytic leukemia (CLL) with unmutated (U-CLL) or mutated (M-CLL) immunoglobulin gene heavy-chain variable region (IGHV) displays different states of anergy, indicated by reduced surface immunoglobulin M (sIgM) levels and signaling, conseq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::425c4d1418c028068aeb1502958ce5e5
http://hdl.handle.net/11365/1005504
http://hdl.handle.net/11365/1005504
Publikováno v:
Journal of Clinical & Cellular Immunology.
Objective: Regulatory T cells (Tregs) are known to infiltrate the tumour microenvironment of many cancers, including head and neck malignancies, and are thought to contribute to the host's impaired anti-tumour immune response. However, their immunosu
Autor:
Annalisa D'Avola, Jonathan C. Strefford, Alison Yeomans, Samantha Drennan, Graham Packham, Matthew J. J. Rose-Zerilli, Andrew J. Steele, Francesco Forconi, Freda K. Stevenson
Publikováno v:
Blood. 128:970-970
Introduction: mRNA translation is increased in activated tumor cells of the aggressive form of Chronic Lymphocytic Leukemia (CLL), typically unmutated (U) immunoglobulin gene heavy-chain variable region (IGHV) with a strong sIgM signaling capacity (Y