Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Samantha Donnellan"'
Autor:
Amrutha Surendran, Agnes Turnbull, Allen Flockhart, Fern Findlay-Greene, Martyna Nowosielska, Donald Morrison, David J. Mincher, Samantha Donnellan
Publikováno v:
All Life, Vol 17, Iss 1 (2024)
We hypothesise that antimicrobial resistance (AMR) cannot be overcome by simply ‘drugging’ single biological targets, therefore, our focus is developing broad-spectrum therapeutics. Herein we present the synthesis of two novel spacer-linked, anth
Externí odkaz:
https://doaj.org/article/ebb787cff8494e1cb3c68429d104f5d3
Autor:
Ghaith Aljayyoussi, Victoria A. Jenkins, Raman Sharma, Alison Ardrey, Samantha Donnellan, Stephen A. Ward, Giancarlo A. Biagini
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Tuberculosis (TB) treatment is long and complex, typically involving a combination of drugs taken for 6 months. Improved drug regimens to shorten and simplify treatment are urgently required, however a major challenge to TB drug development
Externí odkaz:
https://doaj.org/article/eeb7497b0cef443d825c81af2749fe7b
Publikováno v:
Pharmaceutics, Vol 11, Iss 6, p 278 (2019)
Increasing rifampicin (RIF) dosages could significantly reduce tuberculosis (TB) treatment durations. Understanding the pharmacokinetic-pharmacodynamics (PK−PD) of increasing RIF dosages could inform clinical regimen selection. We used intracellula
Externí odkaz:
https://doaj.org/article/f10a671343e44c8da5a982d66688765d
Autor:
Samantha Donnellan, Shaun H Pennington, Alessandra Ruggiero, Carmen Martinez-Rodriguez, Marion Pouget, Jordan Thomas, Steve A Ward, Georgios Pollakis, Giancarlo A Biagini, William A Paxton
Mycobacterium tuberculosis and human immunodeficiency virus-1 (HIV-1) syndemic interactions are a major global health concern. Despite the clinical significance of coinfection, our understanding of the cellular pathophysiology and the therapeutic pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52582433eac0f3039d35d4d1be86167c
https://hdl.handle.net/11562/1085557
https://hdl.handle.net/11562/1085557
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2296
The human disease tuberculosis (TB) is the leading cause of death from a single infectious agent. A quarter of the world's population is estimated to be latently infected. Drug development and screening is slow and costly. We have developed a physiol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::53c9ee4ae5a638e833048435697ff761
https://pubmed.ncbi.nlm.nih.gov/33977461
https://pubmed.ncbi.nlm.nih.gov/33977461
Publikováno v:
Methods in Molecular Biology ISBN: 9781071613573
The human disease tuberculosis (TB) is the leading cause of death from a single infectious agent. A quarter of the world’s population is estimated to be latently infected. Drug development and screening is slow and costly. We have developed a physi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c635aff1fc2613403da15a8be7cf6fd0
https://doi.org/10.1007/978-1-0716-1358-0_23
https://doi.org/10.1007/978-1-0716-1358-0_23
Autor:
Laura N Jeffreys, Shaun H Pennington, Jack Duggan, Claire H Caygill, Rose C Lopeman, Alastair F Breen, Jessica B Jinks, Alison Ardrey, Samantha Donnellan, Edward I Patterson, Grant L Hughes, David W Hong, Paul M O’Neill, Ghaith Aljayyoussi, Andrew Owen, Stephen A Ward, Giancarlo A Biagini
A key element to the prevention and management of the COVID-19 pandemic is the development of effective therapeutics. Drug combination strategies of repurposed drugs offer a number of advantages to monotherapies including the potential to achieve gre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3be06334fa54c60b7259c9da3758b2a
https://doi.org/10.1101/2020.12.23.424232
https://doi.org/10.1101/2020.12.23.424232
Autor:
Laura N. Jeffreys, Shaun H. Pennington, Jack Duggan, Claire H. Caygill, Rose C. Lopeman, Alastair F. Breen, Jessica B. Jinks, Alison Ardrey, Samantha Donnellan, Edward I. Patterson, Grant L. Hughes, David W. Hong, Paul M. O'Neill, Ghaith Aljayyoussi, Andrew Owen, Stephen A. Ward, Giancarlo A. Biagini
Publikováno v:
International Journal of Antimicrobial Agents
A key element for the prevention and management of coronavirus disease 2019 is the development of effective therapeutics. Drug combination strategies offer several advantages over monotherapies. They have the potential to achieve greater efficacy, to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f59d2dcded9a99b9bcac11c48fcec504
https://doi.org/10.1016/j.ijantimicag.2022.106542
https://doi.org/10.1016/j.ijantimicag.2022.106542
Autor:
Ghaith Aljayyoussi, Samantha Donnellan, Emmanuel Moyo, Stephen A. Ward, Alison Ardrey, Giancarlo A. Biagini, C. Martínez-Rodríguez
Publikováno v:
Antimicrobial Agents and Chemotherapy
Clinical studies of new antitubercular drugs are costly and time-consuming. Owing to the extensive tuberculosis (TB) treatment periods, the ability to identify drug candidates based on their predicted clinical efficacy is vital to accelerate the pipe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::809212f0f16065a9c3de52f29a77a384
Autor:
Alison Ardrey, Ghaith Aljayyoussi, Raman Sharma, Giancarlo A. Biagini, Samantha Donnellan, Victoria A. Jenkins, Stephen A. Ward
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports
Scientific Reports
Tuberculosis (TB) treatment is long and complex, typically involving a combination of drugs taken for 6 months. Improved drug regimens to shorten and simplify treatment are urgently required, however a major challenge to TB drug development is the la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08996c99c93e98f418a74b182e517b5d
https://doaj.org/article/eeb7497b0cef443d825c81af2749fe7b
https://doaj.org/article/eeb7497b0cef443d825c81af2749fe7b