Study and application of graphene oxide in the synthesis of 2,3-disubstituted quinolines via a Povarov multicomponent reaction and subsequent oxidation

Autor: Samantha Caputo, Alessandro Kovtun, Francesco Bruno, Enrico Ravera, Chiara Lambruschini, Manuela Melucci, Lisa Moni

Publikováno v: RSC Advances. 12:15834-15847

Graphene oxide is exploited as a heterogeneous, metal-free and sustainable catalyst for the three-component Povarov reaction and subsequent oxidation. The multistep synthesis can also be performed as a one-pot procedure.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f6a062a4e7f4f9d18a468fc1f0254a6
https://doi.org/10.1039/d2ra01752k

Design, Synthesis, and Biological Evaluation of a Series of Oxazolone Carboxamides as a Novel Class of Acid Ceramidase Inhibitors

Autor: Andrea Armirotti, Ilaria Penna, Natasha Margaroli, Rosalia Bertorelli, Piero Tardia, Giuliana Ottonello, Marco Mazzonna, Sine Mandrup Bertozzi, Cilibrasi Vincenzo, Maria Summa, Simona Di Martino, Samantha Caputo, Debora Russo, Marco Migliore, Rita Scarpelli, Renato T. Skerlj, Natalia Realini, Soumya S. Ray, Min Liu, Peter T. Lansbury

Publikováno v: Journal of Medicinal Chemistry

Acid ceramidase (AC) is a cysteine hydrolase that plays a crucial role in the metabolism of lysosomal ceramides, important members of the sphingolipid family, a diversified class of bioactive molecules that mediate many biological processes ranging f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3d0df98193fb63dae8c75902ab6b8b6
https://pubmed.ncbi.nlm.nih.gov/33290061

Multiple Multicomponent Reactions: Unexplored Substrates, Selective Processes and Versatile Chemotypes in Biomedicine

Autor: Jerónimo Pachón, Marc Vendrell, Ryan Treadwell, Anna Aviñó, Rodolfo Lavilla, F. Javier Luque, Marc Revés, Ramon Eritja, Fabio de Moliner, Javier Sánchez-Céspedes, Ana Serna-Gallego, José Antonio Marrugal-Lorenzo, Ouldouz Ghashghaei, Miquel Sintes, Samantha Caputo, Nicola Kielland, Carolina Estarellas

Publikováno v: Lavilla, R, Ghashghaei, O, Caputo, S, Sintes, M, Revés, M, Kielland, N, Estarellas, C, Luque, F J, Aviñó, A, Eritja, R, Marrugal-lorenzo, J A, Serna-gallego, A, Pachón, J, Sánchez-céspedes, J, Treadwell, R, De Moliner, F & Vendrell, M 2018, ' Multiple Multicomponent Reactions: Unexplored Substrates, Selective Processes and Versatile Chemotypes in Biomedicine ', Chemistry-A European Journal . https://doi.org/10.1002/chem.201802877
Digital.CSIC. Repositorio Institucional del CSIC
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Multiple multicomponent reactions rapidly assemble complex structures. Despite being very productive, the lack of selectivity and the reduced number of viable transformations restrict their general application in synthesis. Hereby, we describe a rati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddcb6d94d77be91846129ef2aab0d26f
https://hdl.handle.net/20.500.11820/76a07048-f294-43e9-80c9-123bb771bf51

Diastereoselective Ugi reaction of chiral 1,3-aminoalcohols derived from an organocatalytic Mannich reaction

Autor: Andrea Basso, Samantha Caputo, Lisa Moni, Valeria Rocca, Luca Banfi, Renata Riva

Publikováno v: Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry, Vol 12, Iss 1, Pp 139-143 (2016)

Enantiomerically pure β-aminoalcohols, produced through an organocatalytic Mannich reaction, were subjected to an Ugi multicomponent reaction under classical or Lewis acid-promoted conditions with diastereoselectivities ranging from moderate to good

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f66e75383f17b9d53c67d75262bb64b
http://hdl.handle.net/11567/847234