Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Samantha Bender"'
Autor:
James M. McFarland, Brenton R. Paolella, Allison Warren, Kathryn Geiger-Schuller, Tsukasa Shibue, Michael Rothberg, Olena Kuksenko, William N. Colgan, Andrew Jones, Emily Chambers, Danielle Dionne, Samantha Bender, Brian M. Wolpin, Mahmoud Ghandi, Itay Tirosh, Orit Rozenblatt-Rosen, Jennifer A. Roth, Todd R. Golub, Aviv Regev, Andrew J. Aguirre, Francisca Vazquez, Aviad Tsherniak
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Large-scale screens of chemical and genetic vulnerabilities in cancer are typically limited to simple readouts of cell viability. Here, the authors develop a method for profiling post-perturbation transcriptional responses across large pools of cance
Externí odkaz:
https://doaj.org/article/464481c452404d5080918310ac391162
Autor:
Lucian de Waal, Kevin Larpenteur, Li Wang, Cong Zhu, Jordan Bryan, Mustafa Kocak, Corrie Aghia, Joshua Bittker, Victor Jones, Anita Vrcic, Edward McBride, Samantha Bender, Kalea Gore, Frank Li, Zhenghao Chen, Aviad Tsherniak, Aravind Subramanian, Daphne Koller, Jeffery Settleman, Chris C. Mader, David Stokoe, Ari Firestone, Jennifer A. Roth, Todd R. Golub
Publikováno v:
Cancer Research. 82:1883-1883
Oncology drug discovery has been dependent on phenotypic screening that lead to discovery of many drugs that remain essential cancer treatments to this day. Historically, logistical and technological limitations have hampered the scale of phenotypic
Autor:
Dhvanir Kansara, Eugen Dhimolea, Pallavi Awate, Alana L. Welm, Jordan Bryan, Brian J. Glassner, Zhiyi Liu, Shruti Sharma, Juliette Bouyssou, Rinath Jeselsohn, Aziz Al'Khafaji, Huihui Tang, Myles Brown, Nathanael S. Gray, Joseline Raja, Boris Bartholdy, Cihangir Duy, Aedín C. Culhane, Yu Chen, Xiang Weng, Ricardo De Matos Simoes, Jennifer Roth, Irene Georgakoudi, Dong Gao, Constantine S. Mitsiades, Ari Melnick, Ryosuke Shirasaki, Aviad Tsherniak, Francisca Vazquez, Michal Scheffer, Samantha Bender
Publikováno v:
Cancer Cell
Treatment-persistent residual tumors impede curative cancer therapy. To understand this cancer cell state we generate models of treatment persistence that simulate the residual tumors. We observe that treatment-persistent tumor cells in organoids, xe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27960f6b5655eb355223383013aae78c
https://europepmc.org/articles/PMC8670073/
https://europepmc.org/articles/PMC8670073/
Autor:
William Colgan, Itay Tirosh, Emily Chambers, Andrew Jones, James M. McFarland, Jennifer Roth, Aviad Tsherniak, Michael V. Rothberg, Samantha Bender, Todd R. Golub, Kathryn Geiger-Schuller, Francisca Vazquez, Mahmoud Ghandi, Andrew J. Aguirre, Allison Warren, Olena Kuksenko, Aviv Regev, Orit Rozenblatt-Rosen, Brenton R. Paolella, Danielle Dionne, Tsukasa Shibue, Brian M. Wolpin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Assays to study cancer cell responses to pharmacologic or genetic perturbations are typically restricted to using simple phenotypic readouts such as proliferation rate. Information-rich assays, such as gene-expression profiling, have generally not pe
Autor:
Digamber Rane, Jennifer E. Golden, Richa Arya, Zachary Maben, Roger Schilling, Irini Evnouchidou, Akbar Ali, Tina T Nguyen, Marc Hickey, Samantha Bender, Efstratios Stratikos, Lawrence J. Stern, W. Frank An, Shailesh Metkar
Publikováno v:
J Med Chem
ERAP1 is an endoplasmic reticulum-resident zinc aminopeptidase that plays an important role in the immune system by trimming peptides for loading onto major histocompatibility complex (MHC-I) proteins. Here we report discovery of the first inhibitors
Autor:
Francisca Vazquez, Kathryn Geiger-Schuller, Danielle Dionne, Tsukasa Shibue, Samantha Bender, Todd R. Golub, Aviad Tsherniak, Andrew Jones, Orit Rozenblatt-Rosen, Andrew J. Aguirre, Mahmoud Ghandi, Brenton R. Paolella, James M. McFarland, Aviv Regev, Brian M. Wolpin, Allison Warren, Jennifer Roth, Emily Chambers, Michael V. Rothberg, Itay Tirosh, Olena Kuksenko
Assays to study cancer cell responses to pharmacologic or genetic perturbations are typically restricted to using simple phenotypic readouts such as proliferation rate or the expression of a marker gene. Information-rich assays, such as gene-expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bfc2ab347c32bbb295486f8878ef2cf
Autor:
Aviad Tsherniak, Haim Barr, Hadas Keren-Shaul, Pedro Fernandes, Sidharth V. Puram, Aviv Regev, Alissa C. Greenwald, Zhanna Orlova, Rotem Tal, Samantha Bender, Itay Tirosh, Jennifer Roth, Christopher C. Mader, James M. McFarland, Gabriela Sarti Kinker, Alexander Plotnikov, James W. Rocco, Allison Warren, Christopher Rodman, Orit Rozenblatt-Rosen, Michael S. Cuoco, Bhavna Kumar, Valery Krizhanovsky
Publikováno v:
Nat Genet
Cultured cell lines are the workhorse of cancer research, but it is unclear to what extent they recapitulate the cellular heterogeneity observed among malignant cells in tumors, given the absence of a native tumor microenvironment. Here, we used mult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b4698a5b06cd031ffab45c7adfdb70d
https://doi.org/10.1101/807552
https://doi.org/10.1101/807552
Autor:
Satu Mustjoki, Ernest Fraenkel, Chris C. Mader, Yiguo Hu, Nicky A. Beelen, Jordan Bryan, Ifrah Tariq, Todd R. Golub, Samuel S. Freeman, Vasilis Syrgkanis, Michal Sheffer, Cong Zhu, Eugen Dhimolea, Govinda M. Kamath, Emily Lowry, Channing Yu, Jennifer Roth, Aviad Tsherniak, Marios Giannakis, Suha Naffar-Abu Amara, Lotte Wieten, Aedín C. Culhane, Olli Dufva, Constantine S. Mitsiades, Olga Dashevsky, Rizwan Romee, Sara Gandolfi, Ricardo De Matos Simoes, Minasri Borah, Samantha Bender, Li Wang
Publikováno v:
Nature Genetics, 53(8), 1196-+. Nature Publishing Group
To systematically define molecular features in human tumor cells that determine their degree of sensitivity to human allogeneic natural killer (NK) cells, we quantified the NK cell responsiveness of hundreds of molecularly annotated ‘DNA-barcoded
Autor:
Aedín C. Culhane, Constantine S. Mitsiades, Yiguo Hu, Satu Mustjoki, Olga Dashevsky, Aviad Tsherniak, Jennifer Roth, Li Wang, Samantha Bender, Ricardo De Matos Simoes, Minasri Borah, Christopher C. Mader, Channing Yu, Todd R. Golub, Suha Naffar-Abu Amara, Rizwan Romee, Jordan Bryan, Olli Dufva, Michal Sheffer, Sara Gandolfi, Cong Zhu, Lotte Wieten, Marios Giannakis, Nicky A. Beelen, Emily Lowry
Publikováno v:
Cancer Immunology Research. 9:PO041-PO041
Natural killer (NK) cells exhibit potent activity in pre-clinical models of diverse hematologic malignancies and solid tumors and infusion of high numbers of NK cells, either autologous or allogeneic, after their ex vivo expansion and activation, has
Autor:
Li Wang, Jeff Settleman, Mustafa Kocak, Aaron Boudreau, David Stokoe, Amy Goodale, James Rong, Jordan Byran, Fiona E. McAllister, Josh Bittker, Todd R. Golub, Cong Zhu, Ari J. Firestone, Daphne Koller, Jordan Rossen, Kevin Larpenteur, Nicholas Eriksson, Samantha Bender, Aviad Tsherniak, Christopher C. Mader, Niclas Olsson, Colin Trepicchio, Aravind Subramanian, Jennifer Roth, Frank Li, Federica Piccioni
Publikováno v:
Molecular Cancer Therapeutics. 18:B121-B121
KEAP1-mutant non-small cell lung cancer is a high prevalence indication that responds poorly to conventional chemotherapy owing to constitutive activation of NRF2 and its associated drug metabolism target genes. Using an approach to identify compound