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of 6
pro vyhledávání: '"Samantha B Amat"'
Publikováno v:
eLife, Vol 7 (2018)
Motor learning involves neural circuit modifications in the cerebellar cortex, likely through re-weighting of parallel fiber inputs onto Purkinje cells (PCs). Climbing fibers instruct these synaptic modifications when they excite PCs in conjunction w
Externí odkaz:
https://doaj.org/article/f939885e8b6644f88526190d9d3d688c
Autor:
Samantha B Amat, Matthew J M Rowan, Michael A Gaffield, Audrey Bonnan, Chikako Kikuchi, Hiroki Taniguchi, Jason M Christie
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179347 (2017)
The cerebellar system helps modulate and fine-tune motor action. Purkinje cells (PCs) provide the sole output of the cerebellar cortex, therefore, any cerebellar involvement in motor activity must be driven by changes in PC firing rates. Several diff
Externí odkaz:
https://doaj.org/article/5a5971fc0bb9471b9ba326a726830076
Publikováno v:
Journal of Neurophysiology. 115:413-422
Purkinje cells (PCs) are a major site of information integration and plasticity in the cerebellum, a brain region involved in motor task refinement. Thus PCs provide an ideal location for studying the mechanisms necessary for cerebellum-dependent mot
Autor:
Hirokazu Hirai, Michael A. Gaffield, Samantha B. Amat, Jason M. Christie, Matthew J. M. Rowan
Publikováno v:
eLife, Vol 7 (2018)
Motor learning involves neural circuit modifications in the cerebellar cortex, likely through re-weighting of parallel fiber inputs onto Purkinje cells (PCs). Climbing fibers instruct these synaptic modifications when they excite PCs in conjunction w
Autor:
Ke Zhang, Hiroki Taniguchi, Jason M. Christie, Chikako Kikuchi, Samantha B. Amat, Audrey Bonnan, George J. Augustine, Matthew J. M. Rowan
Publikováno v:
Neuron. 99:999-1015.e6
Purkinje cell dendrites convert excitatory climbing fiber input into signals that instruct plasticity and motor learning. Modulation of instructive signaling may increase the range in which learning is encoded, yet the mechanisms that allow for this