Molecular subtypes of ALS are associated with differences in patient prognosis

Autor: Jarrett Eshima, Samantha A. O’Connor, Ethan Marschall, NYGC ALS Consortium, Robert Bowser, Christopher L. Plaisier, Barbara S. Smith

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)

Variability in ALS disease onset and progression are poorly understood. Our work identifies three distinct molecular states in post-mortem tissue that capture some of the observed differences in patient age of onset and survival.

Externí odkaz: https://doaj.org/article/e5dddfb58d044579bfda0a55877a2662

Walk your Way to Well-Being at Work: Impact of a Treadmill Workstation on Employee Occupational Health Outcomes

Autor: Richard Feinn, Samantha A. O’Connor, Carrie A. Bulger, Gary W. Giumetti, Nathaniel R. Keegan, Berlynn N. Weissner

Publikováno v: Occupational Health Science. 5:345-360

Evidence suggests that many employees spend most of their day sitting at their desk while using a computer workstation. Such sedentary behavior is linked with obesity, heart disease, and reduced arousal and mood. The current study aimed to expand exi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4e154f7ca57f7c9b0e19b314c5c4f8b4
https://doi.org/10.1007/s41542-021-00091-8

Systematic integration of protein-affecting mutations, gene fusions, and copy number alterations into a comprehensive somatic mutational profile

Autor: Shawn S. Striker, Sierra F. Wilferd, Erika M. Lewis, Samantha A. O'Connor, Christopher L. Plaisier

Publikováno v: Cell Reports Methods. 3:100442

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a76d14a8279de5015c9bebd7ffb917b8
https://doi.org/10.1016/j.crmeth.2023.100442

KAT5 regulates neurodevelopmental states associated with G0-like populations in glioblastoma

Autor: Anca B. Mihalas, Sonali Arora, Samantha A. O’Connor, Heather M. Feldman, Christine E. Cucinotta, Kelly Mitchell, John Bassett, Dayoung Kim, Kang Jin, Pia Hoellerbauer, Jennifer Delegard, Melissa Ling, Wesley Jenkins, Megan Kufeld, Philip Corrin, Lucas Carter, Toshio Tsukiyama, Bruce Aronow, Christopher L. Plaisier, Anoop P. Patel, Patrick J. Paddison

SummaryIn solid tumors, G0-like states are likely critical for maintaining developmental hierarchies and cellular heterogeneity and promoting tumor growth/recurrence, yet little is known about tumor G0 states or regulation of their ingress/egress. To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14778bacdf0e8de36e3edf2cc4ee8eab
https://doi.org/10.1101/2022.03.17.484768

Neural G0: a quiescent‐like state found in neuroepithelial‐derived cells and glioma

Autor: Chad M. Toledo, Anoop P. Patel, Samantha A O'Connor, Heather Feldman, Steven M. Pollard, Lucas Carter, Cole Trapnell, Ryan Basom, Jeffrey J. Delrow, Megan Kufeld, Sonali Arora, Philip Corrin, Patrick J. Paddison, José L. McFaline-Figueroa, Christopher L. Plaisier, Pia Hoellerbauer, Hamid Bolouri

Publikováno v: Molecular Systems Biology, Vol 17, Iss 6, Pp n/a-n/a (2021)
O'Connor, S A, Feldman, H M, Arora, S, Hoellerbauer, P, Toledo, C M, Corrin, P, Carter, L, Kufeld, M, Bolouri, H, Basom, R, Delrow, J, McFaline-Figueroa, J L, Trapnell, C, Pollard, S M, Patel, A, Paddison, P J & Plaisier, C L 2021, ' Neural G0 : a quiescent-like state found in neuroepithelial-derived cells and glioma ', Molecular Systems Biology, vol. 17, no. 6, e9522 . https://doi.org/10.15252/msb.20209522
Molecular Systems Biology

Single‐cell RNA sequencing has emerged as a powerful tool for resolving cellular states associated with normal and maligned developmental processes. Here, we used scRNA‐seq to examine the cell cycle states of expanding human neural stem cells (hN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9937fd8bb7fd0de31738ac3a97472fac
https://doaj.org/article/58249d732dc642c29b1b9c5be97d78eb