Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Samantha A. Nelson"'
Autor:
Samantha J. Nelson, John T. Williams, John A. Buglino, Subhalaxmi Nambi, Lisa J. Lojek, Michael S. Glickman, Thomas R. Ioerger, Christopher M. Sassetti
Publikováno v:
mSphere, Vol 8, Iss 4 (2023)
ABSTRACT Mycobacterium tuberculosis is exposed to a variety of stresses during a chronic infection, as the immune system simultaneously produces bactericidal compounds and starves the pathogen of essential nutrients. The intramembrane protease, Rip1,
Externí odkaz:
https://doaj.org/article/3ff0ef3e4c504a0da4ca3f3ee42264fd
Evaluation of IL-1 Blockade as an Adjunct to Linezolid Therapy for Tuberculosis in Mice and Macaques
Autor:
Caylin G. Winchell, Bibhuti B. Mishra, Jia Yao Phuah, Mohd Saqib, Samantha J. Nelson, Pauline Maiello, Chelsea M. Causgrove, Cassaundra L. Ameel, Brianne Stein, H. Jacob Borish, Alexander G. White, Edwin C. Klein, Matthew D. Zimmerman, Véronique Dartois, Philana Ling Lin, Christopher M. Sassetti, JoAnne L. Flynn
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
In 2017 over 550,000 estimated new cases of multi-drug/rifampicin resistant tuberculosis (MDR/RR-TB) occurred, emphasizing a need for new treatment strategies. Linezolid (LZD) is a potent antibiotic for drug-resistant Gram-positive infections and is
Externí odkaz:
https://doaj.org/article/cb9c7db12abd401b9c0a88eb06a4e51b
Autor:
Kenan C. Murphy, Samantha J. Nelson, Subhalaxmi Nambi, Kadamba Papavinasasundaram, Christina E. Baer, Christopher M. Sassetti
Publikováno v:
mBio, Vol 9, Iss 6 (2018)
ABSTRACT Two efficient recombination systems were combined to produce a versatile method for chromosomal engineering that obviates the need to prepare double-stranded DNA (dsDNA) recombination substrates. A synthetic “targeting oligonucleotide” i
Externí odkaz:
https://doaj.org/article/7bcb391be5a34a75b7fca29da7780f2c
Autor:
Nida Javeed, Yueying Cao, Esther Mintzer, Samantha J. Nelson, Zexiang Chen, Athma A. Pai, Phillip W. L. Tai, Suk Namkung, Scot A. Wolfe, Aamir Mir, Erik J. Sontheimer, Stacy Maitland, Eraj Khokhar, Dan Wang, Jiaming Wang, Raed Ibraheim, Guangping Gao, Wen Xue, Tomás Rodríguez, Emmanouela Tsagkaraki
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
Adeno-associated virus (AAV) vectors are important delivery platforms for therapeutic genome editing but are severely constrained by cargo limits. Simultaneous delivery of multiple vectors can limit dose and efficacy and increase safety risks. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b95aee4d8710ab6bb58a155aa6e53c7
https://doi.org/10.1038/s41467-021-26518-y
https://doi.org/10.1038/s41467-021-26518-y
Publikováno v:
Biochimie
Selenium is a vital micronutrient in many organisms. While traces are required for microbial utilization, excess amounts are toxic; thus, selenium can be regarded as a biological “double-edged sword”. Selenium is chemically similar to the essenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2da9cae880e991e19974f854df914360
https://pubmed.ncbi.nlm.nih.gov/33444662
https://pubmed.ncbi.nlm.nih.gov/33444662
Evaluation of IL-1 Blockade as an Adjunct to Linezolid Therapy for Tuberculosis in Mice and Macaques
Autor:
Cassaundra Ameel, Alexander G. White, Matthew D. Zimmerman, Jia Yao Phuah, Edwin Klein, Caylin G. Winchell, Mohd Saqib, Brianne Stein, Véronique Dartois, Christopher M. Sassetti, Pauline Maiello, Chelsea M Causgrove, Bibhuti B. Mishra, JoAnne L. Flynn, H. Jacob Borish, Samantha J. Nelson, Philana Ling Lin
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology, Vol 11 (2020)
In 2017 over 550,000 estimated new cases of multi-drug/rifampicin resistant tuberculosis (MDR/RR-TB) occurred, emphasizing a need for new treatment strategies. Linezolid (LZD) is a potent antibiotic for drug-resistant Gram-positive infections and is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d23e2259e484ed0833511f0d768e0a30
http://europepmc.org/articles/PMC7235418
http://europepmc.org/articles/PMC7235418
Autor:
Berevan Baban, Melissa D. Stuchell-Brereton, Colin E. Kluender, Jennifer Alexander-Brett, Daniel L. Kober, Michael R. Strickland, Yuhua Song, Carl Frieden, Deborah F. Steinberg, Hunter B. Dean, David M. Holtzman, Samantha S. Nelson, Erik D. Roberson, Tom J. Brett
INTRODUCTIONTREM2 is an innate immune receptor expressed on myeloid cells including microglia in the brain. How TREM2 engages different ligands remains poorly understood.METHODSWe used comprehensive BLI analysis to investigate the TREM2 interactions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62cdf7c2658770288c76b91d5eb077ff
Autor:
Daniel L, Kober, Melissa D, Stuchell-Brereton, Colin E, Kluender, Hunter B, Dean, Michael R, Strickland, Deborah F, Steinberg, Samantha S, Nelson, Berevan, Baban, David M, Holtzman, Carl, Frieden, Jennifer, Alexander-Brett, Erik D, Roberson, Yuhua, Song, Tom J, Brett
Publikováno v:
Alzheimers Dement
Triggering receptor expressed on myeloid cells-2 (TREM2) is an immune receptor expressed on microglia that also can become soluble (sTREM2). How TREM2 engages different ligands remains poorly understood.We used comprehensive biolayer interferometry (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3a798ca4fb9b42c5c8ec422c420d49e8
https://pubmed.ncbi.nlm.nih.gov/33090700
https://pubmed.ncbi.nlm.nih.gov/33090700
Autor:
Christina E. Baer, Kenan C. Murphy, Samantha J. Nelson, Christopher M. Sassetti, K. G. Papavinasasundaram, Subhalaxmi Nambi
Publikováno v:
mBio
mBio, Vol 9, Iss 6 (2018)
mBio, Vol 9, Iss 6, p e01467-18 (2018)
mBio, Vol 9, Iss 6 (2018)
mBio, Vol 9, Iss 6, p e01467-18 (2018)
We sought to develop a system that could increase the usefulness of oligonucleotide-mediated recombineering of bacterial chromosomes by expanding the types of modifications generated by an oligonucleotide (i.e., insertions and deletions) and by makin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d39b7c853d703f98a2fa2b6f73d6804
http://europepmc.org/articles/PMC6299477
http://europepmc.org/articles/PMC6299477
Autor:
John D. Leszyk, Samantha J. Nelson, Yu-Shan Cheng, Emily S.C. Rittershaus, Richard Baker, Seung-Hun Baek, Scott A. Shaffer, Inna Krieger, James C. Sacchettini, Subhalaxmi Nambi, Christopher M. Sassetti
Summary Upon inhibition of respiration, which occurs in hypoxic or nitric oxide-containing host microenvironments, Mycobacterium tuberculosis (Mtb) adopts a non-replicating “quiescent” state and becomes relatively unresponsive to antibiotic treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa0c3c99467e0bef6f1e0cb7dd560c9a
https://europepmc.org/articles/PMC6309504/
https://europepmc.org/articles/PMC6309504/