Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Samantha A. Chalmers"'
Autor:
Samantha A. Chalmers, Rajalakshmy Ayilam Ramachandran, Sayra J. Garcia, Evan Der, Leal Herlitz, Jeanette Ampudia, Dalena Chu, Nicole Jordan, Ting Zhang, Ioannis Parodis, Iva Gunnarsson, Huihua Ding, Nan Shen, Michelle Petri, Chi Chiu Mok, Ramesh Saxena, Krishna R. Polu, Stephen Connelly, Cherie T. Ng, Chandra Mohan, Chaim Putterman
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 1 (2022)
T cells are central to the pathogenesis of lupus nephritis (LN), a common complication of systemic lupus erythematosus (SLE). CD6 and its ligand, activated leukocyte cell adhesion molecule (ALCAM), are involved in T cell activation and trafficking. P
Externí odkaz:
https://doaj.org/article/5da04dc9777b4f09af0bd8b936c10fd9
Autor:
Seung Y. Chu, Erik Pong, Christine Bonzon, Ning Yu, Chaim O. Jacob, Samantha A. Chalmers, Chaim Putterman, David E. Szymkowski, William Stohl
Publikováno v:
Journal of Translational Autoimmunity, Vol 4, Iss , Pp 100075- (2021)
Engagement of Fcγ receptor IIb (FcγRIIb) suppresses B cell activation and represents a promising target for therapy in autoimmunity. Obexelimab is a non-depleting anti-human CD19 mAb with an Fc region engineered to have high affinity for human Fcγ
Externí odkaz:
https://doaj.org/article/91722979a7e84632bcf95a6a9239fd8d
Autor:
Ariel D. Stock, Edward R. Bader, Phillip Cezayirli, Julio Inocencio, Samantha A. Chalmers, Reza Yassari, Vijay Yanamadala, Emad Eskandar
Publikováno v:
Frontiers in Medicine, Vol 7 (2020)
A growing body of evidence demonstrates that asymptomatic and pre-symptomatic transmission of SARS-CoV-2 is a major contributor to the COVID-19 pandemic. Frontline healthcare workers in COVID-19 hotspots have faced numerous challenges, including shor
Externí odkaz:
https://doaj.org/article/b1b84e53d2874cd48f48f60fbd86e94c
Autor:
Erica Moore, Michelle W. Huang, Shweta Jain, Samantha A. Chalmers, Fernando Macian, Chaim Putterman
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Objective: In systemic lupus erythematosus (SLE), widespread T cell infiltration into target organs contributes to inflammation and organ damage. Autoreactive T cells become aberrantly activated in this disease due to dysfunctional T cell receptor si
Externí odkaz:
https://doaj.org/article/bc53e8a0a8ee44afba652978e502f195
Autor:
Samantha A. Chalmers, Jing Wen, Jessica Doerner, Ariel Stock, Carla M. Cuda, Hadijat M. Makinde, Harris Perlman, Todd Bosanac, Deborah Webb, Gerald Nabozny, Jay S. Fine, Elliott Klein, Meera Ramanujam, Chaim Putterman
Publikováno v:
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-11 (2018)
Abstract Background Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that affects different end organs, including skin and brain. We and others have previously shown the importance of macrophages in the pathogenesis of cutaneous an
Externí odkaz:
https://doaj.org/article/6f0eb2318849441e9caef153ed2cf9da
Publikováno v:
Journal of Autoimmunity. 98:33-43
Immune-mediated glomerulonephritis is a serious end organ pathology that commonly affects patients with systemic lupus erythematosus (SLE). A classic murine model used to study lupus nephritis (LN) is nephrotoxic serum nephritis (NTN), in which mice
Autor:
Chaim Putterman, Peter Runge, Raquel Furtado, Angelo D'Alessandro, Kari Alitalo, Rajesh Kumar Soni, Giada Mondanelli, Simone Moretti, Sarah Gehrke, Sangeetha Thangaswamy, Wanxia Li Tsai, Giorgia Manni, Grégoire Lauvau, Sheila Spada, Laura Santambrogio, Massimo Gadina, Silvia C. Formenti, Cornelia Halin, Sandra Demaria, Marc Veldhoen, Cristina C. Clement, Roccaldo Sardella, Amanda P. Beck, Samantha A. Chalmers, Francesca Fallarino, Ursula Grohmann, Luisa C. López Cara, Jorge Arasa, Mihaela Skobe, Roberta Galarini, Antonio Macchiarulo, Marco Gargaro, Federica Ianni, Ruben Fernandez-Rodriguez, Sinem Karaman
Publikováno v:
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Nature Communications
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
instname
Nature Communications
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The work was supported by the following grants: NIH-AG045223 and NIH-AI137198 to L.S.; the Swiss National Science Foundation, grant 310030_182528 to C.H.; Telethon GGP17094 and the Associazione Italiana per la Ricerca sul Cancro (AIRC; 19903) to F.F.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274e8892c2cb7a5974dc461a6be74451
Autor:
Seung Y, Chu, Erik, Pong, Christine, Bonzon, Ning, Yu, Chaim O, Jacob, Samantha A, Chalmers, Chaim, Putterman, David E, Szymkowski, William, Stohl
Publikováno v:
Journal of Translational Autoimmunity
Engagement of Fcγ receptor IIb (FcγRIIb) suppresses B cell activation and represents a promising target for therapy in autoimmunity. Obexelimab is a non-depleting anti-human CD19 mAb with an Fc region engineered to have high affinity for human Fcγ
Autor:
Elliott Klein, Deborah Webb, Jay S. Fine, Sayra J. Garcia, Meera Ramanujam, Samantha A. Chalmers, Chaim Putterman, Leal Herlitz
Publikováno v:
Clinical immunology (Orlando, Fla.). 223
Lupus nephritis (LN) is a serious end organ complication of systemic lupus erythematosus. Nephrotoxic serum nephritis (NTN) is an inducible model of LN, which utilizes passive transfer of pre-formed nephrotoxic antibodies to initiate disease. In prev
Autor:
Jessica Doerner, Jing Wen, Deborah Webb, Samantha A. Chalmers, Elliott Klein, Gerald Nabozny, Ariel D. Stock, Meera Ramanujam, Todd Bosanac, Jay S. Fine, Hadijat M. Makinde, Chaim Putterman, Harris Perlman, Carla M. Cuda
Publikováno v:
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-11 (2018)
Arthritis Research & Therapy
Arthritis Research & Therapy
Background Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that affects different end organs, including skin and brain. We and others have previously shown the importance of macrophages in the pathogenesis of cutaneous and neurops