Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Samanta A, Mariani"'
Publikováno v:
HemaSphere, Vol 6, Iss 6, p e737 (2022)
The hierarchical framework of the adult blood system as we know it from current medical and hematology textbooks, displays a linear branching network of dividing and differentiated cells essential for the growth and maintenance of the healthy organis
Externí odkaz:
https://doaj.org/article/73c9c3bfe53741b19e8e5ba8799c3526
Autor:
Svetlana Petruk, Samanta A. Mariani, Marco De Dominici, Patrizia Porazzi, Valentina Minieri, Jingli Cai, Lorraine Iacovitti, Neal Flomenberg, Bruno Calabretta, Alexander Mazo
Publikováno v:
Cell Reports, Vol 19, Iss 2, Pp 295-306 (2017)
Summary: The role of chromatin structure in lineage commitment of multipotent hematopoietic progenitors (HPCs) is presently unclear. We show here that CD34+ HPCs possess a post-replicative chromatin globally devoid of the repressive histone mark H3K2
Externí odkaz:
https://doaj.org/article/5bd388368332412081472e38aff5b32a
Autor:
Marja T. Nevalainen, Bruno Calabretta, Nagarajan Pattabiraman, Vincent Njar, Gino Cingolani, Leonard G. Gomella, David T. Hoang, Hallgeir Rui, Guanjun Xia, Benjamin Leiby, Paolo Fortina, Adam Ertel, Shauna Blackmon, Elyse Ellsworth, Shilpa Gupta, Costas D. Lallas, Edouard Trabulsi, Peter A. McCue, Puranik Purushottamachar, Ayush Dagvadorj, Ravi K. Lokareddy, Marco De Dominici, Samanta A. Mariani, Jenny Vergalli, Lei Gu, Zhiyong Liao
Supplementary Table 4: Genes down-regulated (> 2-fold) by Stat5-shRNA and IST5-002 in K562
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b04c76a8e28cb2743713cf60d3ca3b6
https://doi.org/10.1158/1535-7163.22501908.v1
https://doi.org/10.1158/1535-7163.22501908.v1
Autor:
Marja T. Nevalainen, Bruno Calabretta, Nagarajan Pattabiraman, Vincent Njar, Gino Cingolani, Leonard G. Gomella, David T. Hoang, Hallgeir Rui, Guanjun Xia, Benjamin Leiby, Paolo Fortina, Adam Ertel, Shauna Blackmon, Elyse Ellsworth, Shilpa Gupta, Costas D. Lallas, Edouard Trabulsi, Peter A. McCue, Puranik Purushottamachar, Ayush Dagvadorj, Ravi K. Lokareddy, Marco De Dominici, Samanta A. Mariani, Jenny Vergalli, Lei Gu, Zhiyong Liao
Supplementary Methods. Supplementary Figure 1. Chemical structures of the small molecule IST5-002 analogs. Supplementary Figure 2. IST5-002 inhibits phosphorylation of Stat5 in mouse and human breast cancer cells. Supplementary Figure 3. IST5-002 doe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e3dfff6a37fe75ab4144213045f901
https://doi.org/10.1158/1535-7163.22501902.v1
https://doi.org/10.1158/1535-7163.22501902.v1
Autor:
Marja T. Nevalainen, Bruno Calabretta, Nagarajan Pattabiraman, Vincent Njar, Gino Cingolani, Leonard G. Gomella, David T. Hoang, Hallgeir Rui, Guanjun Xia, Benjamin Leiby, Paolo Fortina, Adam Ertel, Shauna Blackmon, Elyse Ellsworth, Shilpa Gupta, Costas D. Lallas, Edouard Trabulsi, Peter A. McCue, Puranik Purushottamachar, Ayush Dagvadorj, Ravi K. Lokareddy, Marco De Dominici, Samanta A. Mariani, Jenny Vergalli, Lei Gu, Zhiyong Liao
Supplementary Table 3: Genes up-regulated (> 2-fold) by Stat5-shRNA and IST5-002 in K562
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b280acfc4448d6042e6bbbb7c7ad3891
https://doi.org/10.1158/1535-7163.22501914
https://doi.org/10.1158/1535-7163.22501914
Autor:
Marja T. Nevalainen, Bruno Calabretta, Nagarajan Pattabiraman, Vincent Njar, Gino Cingolani, Leonard G. Gomella, David T. Hoang, Hallgeir Rui, Guanjun Xia, Benjamin Leiby, Paolo Fortina, Adam Ertel, Shauna Blackmon, Elyse Ellsworth, Shilpa Gupta, Costas D. Lallas, Edouard Trabulsi, Peter A. McCue, Puranik Purushottamachar, Ayush Dagvadorj, Ravi K. Lokareddy, Marco De Dominici, Samanta A. Mariani, Jenny Vergalli, Lei Gu, Zhiyong Liao
Supplementary Table 5: IST5-002 regulation of known Stat5 target genes in K562 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f575425a25c708938c4d129d32c4ffb
https://doi.org/10.1158/1535-7163.22501896
https://doi.org/10.1158/1535-7163.22501896
Autor:
Marja T. Nevalainen, Bruno Calabretta, Nagarajan Pattabiraman, Vincent Njar, Gino Cingolani, Leonard G. Gomella, David T. Hoang, Hallgeir Rui, Guanjun Xia, Benjamin Leiby, Paolo Fortina, Adam Ertel, Shauna Blackmon, Elyse Ellsworth, Shilpa Gupta, Costas D. Lallas, Edouard Trabulsi, Peter A. McCue, Puranik Purushottamachar, Ayush Dagvadorj, Ravi K. Lokareddy, Marco De Dominici, Samanta A. Mariani, Jenny Vergalli, Lei Gu, Zhiyong Liao
Supplementary Table 2: Genes regulated by both Stat5-shRNA and IST5-002 in K562 cells, corresponding to the heatmap in Figure 2g.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cf61bd52266069319368329bf1ecf51
https://doi.org/10.1158/1535-7163.22501899
https://doi.org/10.1158/1535-7163.22501899
Autor:
Marja T. Nevalainen, Bruno Calabretta, Nagarajan Pattabiraman, Vincent Njar, Gino Cingolani, Leonard G. Gomella, David T. Hoang, Hallgeir Rui, Guanjun Xia, Benjamin Leiby, Paolo Fortina, Adam Ertel, Shauna Blackmon, Elyse Ellsworth, Shilpa Gupta, Costas D. Lallas, Edouard Trabulsi, Peter A. McCue, Puranik Purushottamachar, Ayush Dagvadorj, Ravi K. Lokareddy, Marco De Dominici, Samanta A. Mariani, Jenny Vergalli, Lei Gu, Zhiyong Liao
Supplemental Table 1: Structure-Activity-Relationship analysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a7b001835019e8f58c1cf2058fe1ba6
https://doi.org/10.1158/1535-7163.22501917.v1
https://doi.org/10.1158/1535-7163.22501917.v1
Autor:
Bruno Calabretta, Marja T. Nevalainen, Pierluigi Porcu, Luke F. Peterson, Alessandro Rambaldi, Orietta Spinelli, Samanta A. Mariani, Patrizia Porazzi, Marco De Dominici, Valentina Minieri
Primary human Ph+ ALL samples
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ef6d62ceef6c04e37078b2c582e3932
https://doi.org/10.1158/0008-5472.22420215
https://doi.org/10.1158/0008-5472.22420215
Autor:
Bruno Calabretta, Marja T. Nevalainen, Pierluigi Porcu, Luke F. Peterson, Alessandro Rambaldi, Orietta Spinelli, Samanta A. Mariani, Patrizia Porazzi, Marco De Dominici, Valentina Minieri
Combining standard cytotoxic chemotherapy with BCR-ABL1 tyrosine kinase inhibitors (TKI) has greatly improved the upfront treatment of patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). However, due to the develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e85594dd3e61d78463c9b5678169ed35
https://doi.org/10.1158/0008-5472.c.6510594.v1
https://doi.org/10.1158/0008-5472.c.6510594.v1