Kinetics of immune responses elicited after three mRNA COVID-19 vaccine doses in predominantly antibody-deficient individuals

Autor: Erola Ainsua-Enrich, Núria Pedreño-Lopez, Carmen Bracke, Carlos Ávila-Nieto, María Luisa Rodríguez de la Concepción, Edwards Pradenas, Benjamin Trinité, Silvia Marfil, Cristina Miranda, Sandra González, Ruth Toledo, Marta Font, Susana Benet, Tuixent Escribà, Esther Jimenez-Moyano, Ruth Peña, Samandhy Cedeño, Julia G. Prado, Beatriz Mothe, Christian Brander, Nuria Izquierdo-Useros, Julia Vergara-Alert, Joaquim Segalés, Marta Massanella, Rosa María Benitez, Alba Romero, Daniel Molina-Morant, Julià Blanco, Bonaventura Clotet, Lourdes Mateu, María Luisa Pedro-Botet, Jorge Carrillo

Publikováno v: iScience, Vol 25, Iss 11, Pp 105455- (2022)

Summary: Mass vaccination campaigns reduced COVID-19 incidence and severity. Here, we evaluated the immune responses developed in SARS-CoV-2-uninfected patients with predominantly antibody-deficiencies (PAD) after three mRNA-1273 vaccine doses. PAD p

Externí odkaz: https://doaj.org/article/073012793b3643598393de5b4241a3fc

Does Antigen Glycosylation Impact the HIV-Specific T Cell Immunity?

Autor: Alex Olvera, Samandhy Cedeño, Anuska Llano, Beatriz Mothe, Jorge Sanchez, Gemma Arsequell, Christian Brander

Publikováno v: Frontiers in Immunology, Vol 11 (2021)

It is largely unknown how post-translational protein modifications, including glycosylation, impacts recognition of self and non-self T cell epitopes presented by HLA molecules. Data in the literature indicate that O- and N-linked glycosylation can s

Externí odkaz: https://doaj.org/article/23c54ad9610a4a3c989409f31581faf6

HIVconsv Vaccines and Romidepsin in Early-Treated HIV-1-Infected Individuals: Safety, Immunogenicity and Effect on the Viral Reservoir (Study BCN02)

Autor: Beatriz Mothe, Miriam Rosás-Umbert, Pep Coll, Christian Manzardo, Maria C. Puertas, Sara Morón-López, Anuska Llano, Cristina Miranda, Samandhy Cedeño, Miriam López, Yovaninna Alarcón-Soto, Guadalupe Gómez Melis, Klaus Langohr, Ana M. Barriocanal, Jessica Toro, Irene Ruiz, Cristina Rovira, Antonio Carrillo, Michael Meulbroek, Alison Crook, Edmund G. Wee, Jose M. Miró, Bonaventura Clotet, Marta Valle, Javier Martinez-Picado, Tomáš Hanke, Christian Brander, José Moltó, The BCN02 Study Investigators

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Kick&kill strategies combining drugs aiming to reactivate the viral reservoir with therapeutic vaccines to induce effective cytotoxic immune responses hold potential to achieve a functional cure for HIV-1 infection. Here, we report on an open-label,

Externí odkaz: https://doaj.org/article/488e5500178f4b47bb1f5b03a865f708

Incoming HIV virion-derived Gag Spacer Peptide 2 (p1) is a target of effective CD8(+) T cell antiviral responses

Autor: Hongbing Yang, Anuska Llano, Samandhy Cedeño, Annette von Delft, Angelica Corcuera, Geraldine M. Gillespie, Andrew Knox, Darren B. Leneghan, John Frater, Wolfgang Stöhr, Sarah Fidler, Beatriz Mothe, Johnson Mak, Christian Brander, Nicola Ternette, Lucy Dorrell, Eric Sandström, Janet Darbyshire, Frank Post, Christopher Conlon, Jane Anderson, Mala Maini, Timothy Peto, Peter Sasieni, Veronica Miller, Ian Weller, Abdel Babiker, Sarah Pett, Matthew Pace, Natalia Olejniczak, Helen Brown, Nicola Robinson, Jakub Kopycinski, Tomáš Hanke, Alison Crook, Steven Kaye, Myra McClure, Otto Erlwein, Andrew Lovell, Maryam Khan, Michelle Gabrielle, Rachel Bennett, Aminata Sy, Adam Gregory, Fleur Hudson, Charlotte Russell, Gemma Wood, Hanna Box, Cherry Kingsley, Katie Topping, Andrew Lever, Mark Wills, Axel Fun, Mikaila Bandara, Damian Kelly, Simon Collins, Alex Markham, Mary Rauchenberger, Yinka Sowunmi, Shaadi Shidfar, Dominic Hague, Mark Nelson, Maddalena Cerrone, Nadia Castrillo Martinez, Tristan Barber, Alexandra Schoolmeesters, Christine Weaver, Orla Thunder, Jane Rowlands, Christopher Higgs, Serge Fedele, Margherita Bracchi, Lervina Thomas, Peter Bourke, Nneka Nwokolo, Gaynor Lawrenson, Marzia Fiorino, Hinal Lukha, Sabine Kinloch-de Loes, Margaret Johnson, Alice Nightingale, Nnenna Ngwu, Patrick Byrne, Zoe Cuthbertson, Martin Jones, Tina Fernandez, Amanda Clarke, Martin Fisher, Rebecca Gleig, Vittorio Trevitt, Colin Fitzpatrick, Tanya Adams, Fiounnuala Finnerty, John Thornhill, Heather Lewis, Kristin Kuldanek, Julie Fox, Julianne Lwanga, Hiromi Uzu, Ming Lee, Simon Merle, Patrick O’Rourke, Isabel Jendrulek, Taras Zarko Flynn, Mark Taylor, Juan Manuel Tiraboschi, Tammy Murray

Publikováno v: Cell Reports
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
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Persistence of HIV through integration into host DNA in CD4(+) T cells presents a major barrier to virus eradication. Viral integration may be curtailed when CD8(+) T cells are triggered to kill infected CD4(+) T cells through recognition of histocom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6f7b05b028eaac835e405a6ac4e7c84
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=2035

Incoming HIV Virion-Derived Gag Spacer Peptide 2 (p1) is a Target of Effective CD8+ T Cell Antiviral Responses

Autor: Johnson Mak, Geraldine M. Gillespie, Darren B. Leneghan, Lucy Dorrell, Andrew Alexander Knox, Angelica Corcuera, Beatriz Mothe, Nicola Ternette, Samandhy Cedeño, Hongbing Yang, Annette von Delft, Christian Brander, Sarah Fidler, John Frater, Wolfgang Stöhr, Anuska Llano, River Trial Study Goup

Publikováno v: SSRN Electronic Journal.

Persistence of HIV through integration into host DNA in CD4+ T cells presents a major barrier to virus eradication. Viral integration may be curtailed when CD8+ T cells are triggered to kill infected CD4+ T cells through recognition of HLA class I-bo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ffac2776f051a00ecb4443d7c6517ece
https://doi.org/10.2139/ssrn.3717161