Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Samadhi Aparicio-Siegmund"'
Autor:
Charlotte M. Flynn, Yvonne Garbers, Stefan Düsterhöft, Rielana Wichert, Juliane Lokau, Christian H. K. Lehmann, Diana Dudziak, Bernd Schröder, Christoph Becker-Pauly, Stefan Rose-John, Samadhi Aparicio-Siegmund, Christoph Garbers
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract The cytokine interleukin-6 (IL-6) fulfills its pleiotropic functions via different modes of signaling. Regenerative and anti-inflammatory activities are mediated via classic signaling, in which IL-6 binds to the membrane-bound IL-6 receptor
Externí odkaz:
https://doaj.org/article/5fcbad4a86ec408db5a8eceac4164627
Autor:
Maria Agthe, Julian Brügge, Yvonne Garbers, Marieke Wandel, Birte Kespohl, Philipp Arnold, Charlotte M. Flynn, Juliane Lokau, Samadhi Aparicio-Siegmund, Christian Bretscher, Stefan Rose-John, Georg H. Waetzig, Tracy Putoczki, Joachim Grötzinger, Christoph Garbers
Publikováno v:
Cell Reports, Vol 25, Iss 1, Pp 10-18.e5 (2018)
Summary: Premature closure of the sutures that connect the cranial bones during development of the mammalian skull results in a phenotype called craniosynostosis. Recently, several craniosynostosis patients with missense mutations within the gene enc
Externí odkaz:
https://doaj.org/article/a5e04e6be0b747889149d6367b2b4483
Autor:
Samadhi Aparicio-Siegmund, Jens M Moll, Juliane Lokau, Melanie Grusdat, Jutta Schröder, Svenja Plöhn, Stefan Rose-John, Joachim Grötzinger, Philipp A Lang, Jürgen Scheller, Christoph Garbers
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107990 (2014)
The Interleukin (IL)-12 family contains several heterodimeric composite cytokines which share subunits among each other. IL-12 consists of the subunits p40 (shared with IL-23) and p35. p35 is shared with the composite cytokine IL-35 which comprises o
Externí odkaz:
https://doaj.org/article/7d352694791944468e1405fbb89ef5cf
Autor:
Heiner K. Berthold, Christoph Garbers, Samadhi Aparicio-Siegmund, Matthias Laudes, Ioanna Gouni-Berthold, Yvonne Garbers, Charlotte M. Flynn, Georg H. Waetzig, Wilhelm Krone, Stefan Rose-John
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 317:E411-E420
Serum levels of interleukin-6 (IL-6) are increased in patients with type 2 diabetes (T2D). IL-6 exerts its pleiotropic effects via the IL-6 α-receptor (IL-6R), which exists in membrane-bound and soluble (sIL-6R) forms and activates cells via the β-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea2063a6b3aa3dfd9d30f971eb6b24bd
https://doi.org/10.1152/ajpendo.00166.2019
https://doi.org/10.1152/ajpendo.00166.2019
Autor:
Daniela Wesch, Yvonne Garbers, Matthias Laudes, Charlotte M. Flynn, Juliane Lokau, Dominik M. Schulte, Samadhi Aparicio-Siegmund, Christoph Garbers, Wolfgang Lieb
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
Signaling of the pleiotropic cytokine Interleukin-6 (IL-6) via its soluble IL-6R (sIL-6R) has been termed trans-signaling and is thought to be responsible for the pro-inflammatory properties of IL-6. The sIL-6R can be generated by alternative mRNA sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b1a6ca9ed4261de9df38bfb8325208
http://link.springer.com/article/10.1038/s41598-019-43617-5
http://link.springer.com/article/10.1038/s41598-019-43617-5
Autor:
Joachim Grötzinger, Tracy L Putoczki, Samadhi Aparicio-Siegmund, Julian Brügge, Philipp Arnold, Stefan Rose-John, Yvonne Garbers, Christian Bretscher, Marieke Wandel, Charlotte M. Flynn, Juliane Lokau, Birte Kespohl, Maria Agthe, Georg H. Waetzig, Christoph Garbers
Publikováno v:
Cell Reports, Vol 25, Iss 1, Pp 10-18.e5 (2018)
Summary: Premature closure of the sutures that connect the cranial bones during development of the mammalian skull results in a phenotype called craniosynostosis. Recently, several craniosynostosis patients with missense mutations within the gene enc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5532ca98ff92f53a0dedcb54cc130a8
http://www.sciencedirect.com/science/article/pii/S2211124718314207
http://www.sciencedirect.com/science/article/pii/S2211124718314207
Autor:
Juliane Lokau, Johannes Haybaeck, Tina Daunke, Yvonne Garbers, Stefan Rose-John, Birte Kespohl, Samadhi Aparicio-Siegmund, Christoph Garbers, Charlotte M. Flynn, Stefan Düsterhöft
Publikováno v:
The Journal of Biological Chemistry
Interleukin-6 (IL-6) is a cytokine implicated in proinflammatory as well as regenerative processes and acts via receptor complexes consisting of the ubiquitously expressed, signal-transducing receptor gp130 and the IL-6 receptor (IL-6R). The IL-6R is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecef4ee4b5c9198e71afe5c7ddcbe0c8
https://doi.org/10.1016/j.jbc.2021.100434
https://doi.org/10.1016/j.jbc.2021.100434
Publikováno v:
Biochemical and biophysical research communications. 484(4)
IL-6 exerts its pleiotropic activities on its target cells via the IL-6 alpha-receptor (IL-6R), which is expressed on a limited number of cell types. IL-6 can further signal via soluble forms of its receptor (sIL-6R), a process that has been termed t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29a1aec7fef3c48e02eb4e6439303ff6
https://pubmed.ncbi.nlm.nih.gov/28159554
https://pubmed.ncbi.nlm.nih.gov/28159554
Autor:
Jan Sommer, David Finkenstädt, Ralf Schwanbeck, Klaus Pfeffer, Stefan Rose-John, Niloufar Monhasery, Christoph Garbers, Eric Keil, Jürgen Scheller, Samadhi Aparicio-Siegmund
Publikováno v:
Oncotarget
// Samadhi Aparicio-Siegmund 1 , Jan Sommer 1 , Niloufar Monhasery 1 , Ralf Schwanbeck 2 , Eric Keil 3 , David Finkenstadt 3 , Klaus Pfeffer 3 , Stefan Rose-John 2 , Jurgen Scheller 1 and Christoph Garbers 1,4 1 Institute of Biochemistry and Molecula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c67ed181ee24a87fb3a20f881ef06b0e
http://europepmc.org/articles/PMC4039151
http://europepmc.org/articles/PMC4039151
Autor:
Jürgen Scheller, Annika Sommerfeld, Fabian Kuck, Roland P. Piekorz, Klaus Schulze-Osthoff, Stefan Rose-John, Philipp A. Lang, Mareike Kessenbrock, Christoph Garbers, Kirstin Konzak, Tak W. Mak, Frank Essmann, Dirk Brenner, Dieter Häussinger, Samadhi Aparicio-Siegmund
Publikováno v:
Cell Cycle. 12:3421-3432
Interleukin 6 (IL-6) signaling plays a role in inflammation, cancer, and senescence. Here, we identified soluble IL-6 receptor (sIL-6R) as a member of the senescence-associated secretory phenotype (SASP). Senescence-associated sIL-6R upregulation was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ffa1fad77f712cde7269e78e4dd475
https://doi.org/10.4161/cc.26431
https://doi.org/10.4161/cc.26431