Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Samadhan Kshirsagar"'
Autor:
Vishal Patel, Amit Joharapurkar, Samadhan Kshirsagar, Maulik Patel, Hardikkumar Savsani, Ashvinkumar Patel, Ramchandra Ranvir, Mukul Jain
Publikováno v:
Medicine in Drug Discovery, Vol 16, Iss , Pp 100142- (2022)
Ulcerative colitis and gastric ulcer are ulcers of gastrointestinal track, especially associated with elevated oxidative stress and inflammation. Dimethyl fumarate (DMF) is used for the treatment of multiple sclerosis and psoriasis and is considered
Externí odkaz:
https://doaj.org/article/939960d349e24703b46dd2eb50f7b64e
An anal fissure is a longitudinal ulcerated area in the vertical axis of the squamous lining of the anal canal between the anal verge and the dentate line, noted in 10–15% of proctological patients. Present study was aimed to study, acut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02a745c0bba390cb0a8b838e6861e784
Autor:
Maulik Patel, Vishal Patel, Mukul R. Jain, Rajesh Bahekar, Amit Joharapurkar, Samadhan Kshirsagar, Hardikkumar Savsani
Publikováno v:
Drug Research. 70:376-384
Background Obesity and diabetes are major metabolic disorders that progress to severe morbidity and mortality. Neuroendocrine mechanisms controlling energy balance indicate that combination therapies are needed to sustain weight loss. Lorcaserin was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8d6c024f7676aeb5e6935094e8af03e
https://doi.org/10.1055/a-1201-2700
https://doi.org/10.1055/a-1201-2700
Autor:
Vishal Patel, Amit Joharapurkar, Samadhan Kshirsagar, Maulik Patel, Hiren Patel, Hardikkumar Savsani, Mukul Jain
Publikováno v:
Toxicology and applied pharmacology. 434
Dyslipidemia or its severe version like familial hypercholesterolemia causes a high risk for cardiovascular diseases. Lomitapide, a microsomal triglyceride transfer protein inhibitor, is approved to treat familial hypercholesterolemia, associated wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3802d23d578463b0861c734847b384b8
https://pubmed.ncbi.nlm.nih.gov/34902352
https://pubmed.ncbi.nlm.nih.gov/34902352
Autor:
Mukul R. Jain, Vishal Patel, Samadhan Kshirsagar, Hardikkumar Savsani, Maulik Patel, Amit Joharapurkar
Publikováno v:
Basicclinical pharmacologytoxicologyREFERENCES. 130(1)
Inhibiting the intestinal and renal neutral amino acid transporter B0AT1 by genetic means has improved insulin sensitivity in mice, but there are no antagonists available for preclinical or clinical use. Since the anti-inflammatory agent nimesulide s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67fa97f86540da97ffdd903a5bcf3182
https://pubmed.ncbi.nlm.nih.gov/34634192
https://pubmed.ncbi.nlm.nih.gov/34634192
Autor:
Jigar, Desai, Bhaumin, Patel, Brijesh, Darji, Archana, Gite, Nandini, Panchal, Gokul, Bhosale, Sandeep, Shedage, Sandip, Patel, Pravin, Kadam, Gautam, Patel, Brijesh, Kumar Srivastava, Amit, Joharapurkar, Samadhan, Kshirsagar, Poonam, Giri, Hitesh, Bhayani, Ankit, Patel, Krishnarup, Ghoshdastidar, Debdutta, Bandyopadhyay, Sanjay, Kumar, Mukul, Jain, Rajiv, Sharma
Publikováno v:
Bioorganicmedicinal chemistry letters. 53
Amino acid restriction by inhibition of neutral amino acid transporter, B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1c663a0c24146a8954bef975489f98ee
https://pubmed.ncbi.nlm.nih.gov/34718128
https://pubmed.ncbi.nlm.nih.gov/34718128
Autor:
Vishal Patel, Amit Joharapurkar, Maulik Patel, Hardikkumar Savsani, Hiren Patel, Samadhan Kshirsagar, Mukul R. Jain
Publikováno v:
Drug research. 71(9)
Background Hepcidin, a liver-derived peptide, regulates the absorption, distribution, and circulation of iron in the body. Inflammation or iron overload stimulates hepcidin release, which causes the accumulation of iron in tissues. The inadequate lev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed84c858d5c7edbb19e9479914c94d42
https://pubmed.ncbi.nlm.nih.gov/34311475
https://pubmed.ncbi.nlm.nih.gov/34311475
Activation of GLP-1 and Glucagon Receptors Regulates Bile Homeostasis Independent of Thyroid Hormone
Autor:
Brijesh Sutariya, Maulik Patel, Mukul R. Jain, Rajesh Bahekar, Samadhan Kshirsagar, Amit Joharapurkar, Vishal Patel
Publikováno v:
Current Molecular Pharmacology. 12:139-146
Background:Balanced coagonists of glucagon-like peptide-1 (GLP-1) and glucagon receptors are emerging therapies for the treatment of obesity and diabetes. Such coagonists also regulate lipid metabolism, independent of their body weight lowering effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcbcc2aa61cc5ee1001c48bcfd2957a8
https://doi.org/10.2174/1874467212666190212112402
https://doi.org/10.2174/1874467212666190212112402
Autor:
Maulik Patel, Vishal Patel, Hardikkumar Savsani, Mukul R. Jain, Samadhan Kshirsagar, Amit Joharapurkar
Publikováno v:
European journal of pharmacology. 899
Diabetic retinopathy is a serious complication of diabetes, marked by retinal vascular damage, inflammation, and angiogenesis. This study's objective was to assess the potential benefits of saroglitazar, a peroxisome proliferator-activated receptor-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1800c0e50af0dc13ecf5103520414ba
https://pubmed.ncbi.nlm.nih.gov/33753107
https://pubmed.ncbi.nlm.nih.gov/33753107
Autor:
Vishal Patel, Hardikkumar Savsani, Samadhan Kshirsagar, Maulik Patel, Amit Joharapurkar, Mukul R. Jain
Publikováno v:
Drug development researchREFERENCES. 82(6)
Chronic kidney disease (CKD) is associated with activated inflammatory responses. Desidustat, a prolyl hydroxylase (PHD) inhibitor is useful for treatment of anemia associated with CKD, but its effect on the inflammatory and fibrotic changes in CKD i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cfc80f112ac0b3e362aa56d65dc053d
https://pubmed.ncbi.nlm.nih.gov/33480036
https://pubmed.ncbi.nlm.nih.gov/33480036