Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Samad Ponery"'
Autor:
Neng-Yang Shih, David B. Belanger, Jennifer Jones, Mengwei Hu, Yushi Xiao, Patrick J. Curran, Andrea D. Basso, Elizabeth Smith, Angela Kerekes, Samad Ponery, Winifred W. Prosise, Lata Ramanathan, Jayaram R. Tagat, Johannes H. Voigt, Tao Yu, Yonglian Zhang, Doll Ronald J, Sara Esposite, M. Arshad Siddiqui, Lianzhu Liang, Ming Liu, Amit K. Mandal, Suining Lee, Seema Tevar, Kimberly Gray, Alan Hruza
Publikováno v:
ACS Medicinal Chemistry Letters. 1:214-218
The imidazo-[1,2-a]-pyrazine (1) is a dual inhibitor of Aurora kinases A and B with modest cell potency (IC50 = 250 nM) and low solubility (5 μM). Lead optimization guided by the binding mode led to the acyclic amino alcohol 12k (SCH 1473759), which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdb38c49ba025b07a5cfa2162b25788f
https://doi.org/10.1021/ml100063w
https://doi.org/10.1021/ml100063w
Autor:
Ernest, Adeghate, Abdul Samad, Ponery
Publikováno v:
Neuro endocrinology letters. 25(6)
To examine the effect of ipamorelin (IPA), a novel pentapeptide with a strong growth hormone releasing potency, on insulin secretion from pancreatic tissue fragments of normal and diabetic rats.Diabetes mellitus was induced by streptozotocin (60 mg k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::15e0659cf9ed5df5602cfe1df6a9eb0a
https://pubmed.ncbi.nlm.nih.gov/15665799
https://pubmed.ncbi.nlm.nih.gov/15665799
Publikováno v:
Neuro endocrinology letters. 20(5)
OBJECTIVES: The distribution of serotonin (5-HT) and its effect on insulin and glucagon secretion were investigated to examine whether there are changes in the pattern of distribution and effect of 5-HT after the onset of experimental diabetes. METHO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::46d7537d71fbd649269e3ed4b106b421
https://pubmed.ncbi.nlm.nih.gov/11460094
https://pubmed.ncbi.nlm.nih.gov/11460094
Autor:
Asra Mirza, Ming Liu, Xiaoying Wang, Stephane L. Bogen, Yao Ma, Philip Lipari, Walter Robert Bishop, Cynthia Seidel-Dugan, Yinghui Liu, Doll Ronald J, Gerald W. Shipps, Yaolin Wang, Daniel J. Hicklin, Suxing Liu, Abdul-Samad Ponery
Publikováno v:
Cancer Research. 70:4533-4533
The HDM2-p53 protein-protein interaction is well characterized through X-ray crystallography. Disrupting this HDM2-p53 protein-protein interaction by a small molecule would therefore release the p53 from the negative inhibition of HDM2 and restore it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc6ac81225a417ac22b4605a3c4657c0
https://doi.org/10.1158/1538-7445.am10-4533
https://doi.org/10.1158/1538-7445.am10-4533
Autor:
Elizabeth Smith, Arshad Siddiqui, Paul Kirschmeier, Jay Tagat, Fredrick Monsma, Yushi Xiao, Ming Liu, Seema Tevar, David B. Belanger, Doll Ronald J, Sara Esposite, Suining Lee, Tao Yu, Dan Hicklin, Samad Ponery, Andrea D. Basso, Kimberly Gray, Yonglain Zhang
Publikováno v:
Cancer Research. 70:1648-1648
Aurora kinases are required for orderly progression of cells through mitosis. Inhibition of these kinases by siRNA or a small molecule inhibitors results in aberrant endoreduplication and cell death. SCH 1473759 is a novel Aurora inhibitor with poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::088363723344b576ea6e37524c8707cb
https://doi.org/10.1158/1538-7445.am10-1648
https://doi.org/10.1158/1538-7445.am10-1648