Výsledky vyhledávání - "Samaa S. Kamar"

Akademický článek

Metformin Suppresses Thioacetamide-Induced Chronic Kidney Disease in Association with the Upregulation of AMPK and Downregulation of Oxidative Stress and Inflammation as Well as Dyslipidemia and Hypertension

Autor: Mohammad Y. Alshahrani, Hasnaa A. Ebrahim, Saeed M. Alqahtani, Nervana M. Bayoumy, Samaa S. Kamar, Asmaa M. ShamsEldeen, Mohamed A. Haidara, Bahjat Al-Ani, Alia Albawardi

Publikováno v: Molecules, Vol 28, Iss 6, p 2756 (2023)

Toxic chemicals such as carbon tetrachloride and thioacetamide (TAA) are reported to induce hepato-nephrotoxicity. The potential protective outcome of the antidiabetic and pleiotropic drug metformin against TAA-induced chronic kidney disease in assoc

Externí odkaz: https://doaj.org/article/96fb4997c3e64e99a144112c94d16d48

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Akademický článek

Metformin Is Associated with the Inhibition of Renal Artery AT1R/ET-1/iNOS Axis in a Rat Model of Diabetic Nephropathy with Suppression of Inflammation and Oxidative Stress and Kidney Injury

Autor: Amal F. Dawood, Amro Maarouf, Norah M. Alzamil, Maha A. Momenah, Ayed A. Shati, Nervana M. Bayoumy, Samaa S. Kamar, Mohamed A. Haidara, Asmaa M. ShamsEldeen, Hanaa Z. Yassin, Peter W. Hewett, Bahjat Al-Ani

Publikováno v: Biomedicines, Vol 10, Iss 7, p 1644 (2022)

Diabetes is the most common cause of end-stage renal disease, also called kidney failure. The link between the renal artery receptor angiotensin II type I (AT1R) and endothelin-1 (ET-1), involved in vasoconstriction, oxidative stress, inflammation an

Externí odkaz: https://doaj.org/article/600eb28520a941abbebb24d26f02891a

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Akademický článek

MiR-155 Dysregulation Is Associated with the Augmentation of ROS/p53 Axis of Fibrosis in Thioacetamide-Induced Hepatotoxicity and Is Protected by Resveratrol

Autor: Amal F. Dawood, Suliman Al Humayed, Maha A. Momenah, Mohamed El-Sherbiny, Hend Ashour, Samaa S. Kamar, Asmaa M. ShamsEldeen, Mohamed A. Haidara, Bahjat Al-Ani, Hasnaa A. Ebrahim

Publikováno v: Diagnostics, Vol 12, Iss 7, p 1762 (2022)

Liver fibrosis is a hallmark of thioacetamide (TAA) intoxications. MicroRNAs (miRs), such as miR-155, have been implied in the pathogenesis of liver disease, and regulated by the antioxidant and anti-inflammatory compound resveratrol (RES). The link

Externí odkaz: https://doaj.org/article/33bd274a9576411487c0ff5eaa253473

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Akademický článek

Metformin Protects against Diabetic Cardiomyopathy: An Association between Desmin–Sarcomere Injury and the iNOS/mTOR/TIMP-1 Fibrosis Axis

Autor: Amal F. Dawood, Norah M. Alzamil, Peter W. Hewett, Maha A. Momenah, Mohammad Dallak, Samaa S. Kamar, Dina H. Abdel Kader, Hanaa Yassin, Mohamed A. Haidara, Amro Maarouf, Bahjat Al-Ani

Publikováno v: Biomedicines, Vol 10, Iss 5, p 984 (2022)

The intermediate filament protein desmin is essential for maintaining the structural integrity of sarcomeres, the fundamental unit of cardiac muscle. Diabetes mellitus (DM) can cause desmin to become dysregulated, following episodes of nitrosative st

Externí odkaz: https://doaj.org/article/dcc02c6c30bc4f4f944e8136ff856c0a

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Resveratrol suppresses cholestasis‐induced liver injury and fibrosis in rats associated with the inhibition of TGFβ1–Smad3–miR21 axis and profibrogenic and hepatic injury biomarkers

Autor: Ayman M. Farag, Suliman Al Humayed, Mohammed Ali Eshra, Samaa S Kamar, Asmaa Mohammed ShamsEldeen, Mohamed A Haidara, Bahjat Al-Ani, Laila A. Rashed, Hasnaa Ali Ebrahim, Abeer Attia, Amul M. Badr

Publikováno v: Clinical and Experimental Pharmacology and Physiology. 48:1402-1411

Cholestasis caused by slowing or blockage of bile flow is a serious liver disease that can lead to liver fibrosis and cirrhosis. The link between transforming growth factor beta 1 (TGFβ1), Smad family member 3 (Smad3), and microRNA 21 (miR21) in bil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2cfdec54190aa97a3dea86776c4d5b3
https://doi.org/10.1111/1440-1681.13546

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Metformin impairs homing ability and efficacy of mesenchymal stem cells for cardiac repair in streptozotocin-induced diabetic cardiomyopathy in rats

Autor: Asmaa Mohammed ShamsEldeen, Abhay Srivastava, Samaa S Kamar, Sanjiv Dhingra, Heba Samy Shoukry, Hend Ashour, Hania Ibrahim Ammar, Laila A. Rashed, Mostafa S. Fadel

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 320:H1290-H1302

Bone marrow-derived mesenchymal stem cells (BM-MSCs) have demonstrated potential in treating diabetic cardiomyopathy. However, patients with diabetes are on multiple drugs and there is a lack of understanding of how transplanted stem cells would resp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ecfd4744713787e3f8e2c16ab019a95
https://doi.org/10.1152/ajpheart.00317.2020

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