Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Sama I. Sayin"'
Autor:
Ella A. Eklund, Ali Mourad, Clotilde Wiel, Sama I. Sayin, Henrik Fagman, Andreas Hallqvist, Volkan I. Sayin
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundKRAS mutation status is a well-established independent prognostic factor in advanced non-small cell lung cancer (NSCLC), yet its role in early-stage disease is unclear. Here, we investigate the prognostic value of combining survival data on
Externí odkaz:
https://doaj.org/article/7f620151d599452782b18578119a2487
Publikováno v:
Cell metabolism. 24(1)
The gut microbiota is considered a metabolic "organ" that not only facilitates harvesting of nutrients and energy from the ingested food but also produces numerous metabolites that signal through their cognate receptors to regulate host metabolism. O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bd9cd60deb5185132edf847d8cb0abf
https://pubmed.ncbi.nlm.nih.gov/27320064
https://pubmed.ncbi.nlm.nih.gov/27320064
Autor:
Kadiombo Bantubungi, Yasmine Sebti, Emilie Dorchies, Emmanuelle Vallez, Nathalie Hennuyer, Olivier Briand, Sophie Lestavel, Alessia Perino, Anne Tailleux, Philippe Marchetti, Jerome Kluza, Philippe Lefebvre, Robert Caiazzo, Sama I. Sayin, Cheryl A. Brighton, Sarah Ducastel, Véronique Touche, Fiona M. Gribble, Hélène Dehondt, Bart Staels, Mohamed-Sami Trabelsi, Frank Reimann, Valeria Spinelli, Janne Prawitt, Fredrik Bäckhed, Kristina Schoonjans, Mehdi Daoudi, François Pattou, Gregory Baud, Sandrine Caron
Publikováno v:
Nature communications
Bile acids are signalling molecules, which activate the transmembrane receptor TGR5 and the nuclear receptor FXR. BA sequestrants (BAS) complex bile acids in the intestinal lumen and decrease intestinal FXR activity. The BAS-BA complex also induces g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60026df928177ea3fadaacddf1c9a4e9
https://doi.org/10.1038/ncomms8629
https://doi.org/10.1038/ncomms8629
Autor:
Jenny Felin, Krister Bamberg, Bo Angelin, Tuulia Hyötyläinen, Matej Orešič, Sirkku Jäntti, Fredrik Bäckhed, Sama I. Sayin, Hanns-Ulrich Marschall, Annika Wahlström
Publikováno v:
Cell Metabolism
Sayin, S I, Wahlström, A, Felin, J, Jäntti, S, Marschall, H-U, Bamberg, K, Angelin, B, Hyötyläinen, T, Orešič, M & Bäckhed, F 2013, ' Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist ', Cell Metabolism, vol. 17, no. 2, pp. 225-235 . https://doi.org/10.1016/j.cmet.2013.01.003
Sayin, S I, Wahlström, A, Felin, J, Jäntti, S, Marschall, H-U, Bamberg, K, Angelin, B, Hyötyläinen, T, Orešič, M & Bäckhed, F 2013, ' Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist ', Cell Metabolism, vol. 17, no. 2, pp. 225-235 . https://doi.org/10.1016/j.cmet.2013.01.003
Bile acids are synthesized from cholesterol in the liver and further metabolized by the gut microbiota into secondary bile acids. Bile acid synthesis is under negative feedback control through activation of the nuclear receptor farnesoid X receptor (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60ed5e8d19d3b215412a112f872e584