Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Sama Adnan"'
1
Akademický článek
Persistent Low-Level Replication of SIVΔnef Drives Maturation of Antibody and CD8 T Cell Responses to Induce Protective Immunity against Vaginal SIV Infection.
Autor: Sama Adnan, R Keith Reeves, Jacqueline Gillis, Fay E Wong, Yi Yu, Jeremy V Camp, Qingsheng Li, Michelle Connole, Yuan Li, Michael Piatak, Jeffrey D Lifson, Wenjun Li, Brandon F Keele, Pamela A Kozlowski, Ronald C Desrosiers, Ashley T Haase, R Paul Johnson
Publikováno v: PLoS Pathogens, Vol 12, Iss 12, p e1006104 (2016)
Defining the correlates of immune protection conferred by SIVΔnef, the most effective vaccine against SIV challenge, could enable the design of a protective vaccine against HIV infection. Here we provide a comprehensive assessment of immune response
Externí odkaz: https://doaj.org/article/06b3afcb40fe45a695d045607398c274
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2
Akademický článek
Characterization of CD8+ T cell differentiation following SIVΔnef vaccination by transcription factor expression profiling.
Autor: James M Billingsley, Premeela A Rajakumar, Michelle A Connole, Nadine C Salisch, Sama Adnan, Yury V Kuzmichev, Henoch S Hong, R Keith Reeves, Hyung-joo Kang, Wenjun Li, Qingsheng Li, Ashley T Haase, R Paul Johnson
Publikováno v: PLoS Pathogens, Vol 11, Iss 3, p e1004740 (2015)
The onset of protective immunity against pathogenic SIV challenge in SIVΔnef-vaccinated macaques is delayed for 15-20 weeks, a process that is related to qualitative changes in CD8+ T cell responses induced by SIVΔnef. As a novel approach to charac
Externí odkaz: https://doaj.org/article/5fbe518dbfca4582888711391c84f7e3
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3
Akademický článek
CD8 T cell response maturation defined by anentropic specificity and repertoire depth correlates with SIVΔnef-induced protection.
Autor: Sama Adnan, Arnaud D Colantonio, Yi Yu, Jacqueline Gillis, Fay E Wong, Ericka A Becker, Michael Piatak, R Keith Reeves, Jeffrey D Lifson, Shelby L O'Connor, R Paul Johnson
Publikováno v: PLoS Pathogens, Vol 11, Iss 2, p e1004633 (2015)
The live attenuated simian immunodeficiency virus (LASIV) vaccine SIVΔnef is one of the most effective vaccines in inducing protection against wild-type lentiviral challenge, yet little is known about the mechanisms underlying its remarkable protect
Externí odkaz: https://doaj.org/article/8fd943c4d1fd42498617beb0f66b54b1
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6
Persistent Low-Level Replication of SIVΔnef Drives Maturation of Antibody and CD8 T Cell Responses to Induce Protective Immunity against Vaginal SIV Infection
Autor: R. Keith Reeves, Qingsheng Li, Michelle Connole, Yi Yu, R. Paul Johnson, Jeremy V. Camp, Pamela A. Kozlowski, Wenjun Li, Jeffrey D. Lifson, Yuan Li, Fay E. Wong, Michael Piatak, Jacqueline Gillis, Brandon F. Keele, Sama Adnan, Ashley T. Haase, Ronald C. Desrosiers
Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 12, Iss 12, p e1006104 (2016)
Defining the correlates of immune protection conferred by SIVΔnef, the most effective vaccine against SIV challenge, could enable the design of a protective vaccine against HIV infection. Here we provide a comprehensive assessment of immune response
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bc9df1a05ba710665e1bc755304b644
https://pubmed.ncbi.nlm.nih.gov/27959961
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7
Characterization of CD8+ T cell differentiation following SIVΔnef vaccination by transcription factor expression profiling
Autor: Nadine C. Salisch, R. Keith Reeves, Hyung joo Kang, Sama Adnan, R. Paul Johnson, Henoch S. Hong, Yury V. Kuzmichev, Qingsheng Li, James M. Billingsley, Premeela A. Rajakumar, Michelle Connole, Ashley T. Haase, Wenjun Li
Publikováno v: PLoS Pathogens, Vol 11, Iss 3, p e1004740 (2015)
PLoS Pathogens
The onset of protective immunity against pathogenic SIV challenge in SIVΔnef-vaccinated macaques is delayed for 15-20 weeks, a process that is related to qualitative changes in CD8+ T cell responses induced by SIVΔnef. As a novel approach to charac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73bd5aed8adfafcadb66cfed067c3a2d
http://europepmc.org/articles/PMC4358830?pdf=render
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8
CD8 T cell response maturation defined by anentropic specificity and repertoire depth correlates with SIVΔnef-induced protection
Autor: Shelby L. O’Connor, Arnaud D. Colantonio, Fay E. Wong, Sama Adnan, Yi Yu, Ericka A. Becker, Michael Piatak, Jeffrey D. Lifson, Jacqueline Gillis, R. Paul Johnson, R. Keith Reeves
Publikováno v: PLoS Pathogens, Vol 11, Iss 2, p e1004633 (2015)
PLoS Pathogens
The live attenuated simian immunodeficiency virus (LASIV) vaccine SIVΔnef is one of the most effective vaccines in inducing protection against wild-type lentiviral challenge, yet little is known about the mechanisms underlying its remarkable protect
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eb8eda546750328c46eb7c6db9322a7
http://europepmc.org/articles/PMC4334552?pdf=render
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9
Gag-specific CD8+ T lymphocytes recognize infected cells before AIDS-virus integration and viral protein expression
Autor: Alexander T. Bean, Sama Adnan, David I. Watkins, David B. Allison, Chungwon Chung, Wonhee Lee, Otto O. Yang, Anna K. Jonas, Nancy A. Wilson, John T. Loffredo, Akihiko Hoji, Eva G. Rakasz, Sean P. Spencer, Jonah B. Sacha, Benjamin J. Burwitz, Jeffrey D. Lifson, Thomas C. Friedrich, Jason J. Stephany
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 178(5)
CD8+ T cells are a key focus of vaccine development efforts for HIV. However, there is no clear consensus as to which of the nine HIV proteins should be used for vaccination. The early proteins Tat, Rev, and Nef may be better CD8+ T cell targets than
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5d918112c505a5705fccf31593d6707
https://pubmed.ncbi.nlm.nih.gov/17312117
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10
Nef interference with HIV-1-specific CTL antiviral activity is epitope specific
Autor: Christian Brander, Arumugam Balamurugan, Ayub Ali, Alicja Trocha, Michael S. Bennett, Hwee L. Ng, Sama Adnan, Otto O. Yang
Publikováno v: Blood. 108(10)
HIV-1 Nef and HIV-1–specific cytotoxic T lymphocytes (CTLs) have important and opposing roles in the immunopathogenesis of HIV-1 infection. Nef-mediated down-modulation of HLA class I on infected cells can confer resistance to CTL clearance, but th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb217dd4b28022e8b8e5acb9fe707fb0
https://pubmed.ncbi.nlm.nih.gov/16882705
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