Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Sam Watcham"'
Autor:
Juan Li, Matthew J. Williams, Hyun Jung Park, Hugo P. Bastos, Xiaonan Wang, Daniel Prins, Nicola K. Wilson, Carys Johnson, Kendig Sham, Michelle Wantoch, Sam Watcham, Sarah J. Kinston, Dean C. Pask, Tina L. Hamilton, Rachel Sneade, Amie K. Waller, Cedric Ghevaert, George S. Vassiliou, Elisa Laurenti, David G. Kent, Berthold Göttgens, Anthony R. Green
Publikováno v:
Blood. 140(14)
Adult hematopoietic stem cells (HSCs) are predominantly quiescent and can be activated in response to acute stress such as infection or cytotoxic insults. STAT1 is a pivotal downstream mediator of interferon (IFN) signaling and is required for IFN-in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0b3473e03ba7545c979340a928a1812
https://pubmed.ncbi.nlm.nih.gov/35767701
https://pubmed.ncbi.nlm.nih.gov/35767701
Autor:
Hugo P. Bastos, Berthold Göttgens, Daniel Prins, Hyun Jung Park, Sam Watcham, Juan Li, Alexander Gerbaulet, Michele Vacca, Antonio Vidal-Puig, Anthony R. Green
Publikováno v:
Science Advances
Mutant CALR drives ET at multiple stages of hematopoiesis.
Frameshift mutations in CALR (calreticulin) are associated with essential thrombocythemia (ET), but the stages at and mechanisms by which mutant CALR drives transformation remain incompl
Frameshift mutations in CALR (calreticulin) are associated with essential thrombocythemia (ET), but the stages at and mechanisms by which mutant CALR drives transformation remain incompl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7582df2fd28b332fb195792da20f5ce9
https://pubmed.ncbi.nlm.nih.gov/33239297
https://pubmed.ncbi.nlm.nih.gov/33239297
Autor:
Tomoya Isobe, Iwo Kucinski, Xiaonan Wang, Melania Barile, Rebecca Hannah, George Giotopoulos, Sarah Horton, Ludovica Marando, Juan Li, Justyna Rak, Malgorzata Gozdecka, Meng Wang, Daniel Prins, Hyun Jung Park, Sam Watcham, Ketan Patel, Anthony Green, David Kent, George Vassiliou, Brian Huntly, Nicola Wilson, Berthold Göttgens
Publikováno v:
Experimental Hematology. 111:S35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25aaf11471d112d5125822f3f43a4cc2
https://doi.org/10.1016/j.exphem.2022.07.040
https://doi.org/10.1016/j.exphem.2022.07.040
Autor:
Etsuro Ito, Seiji Kojima, Kenichi Yoshida, Rui Yu, Camille Nadler, Paul S. Monks, Asuka Hira, Nicola K. Wilson, Motohiro Kato, Ashley N. Kamimae-Lanning, Satoru Miyano, Hiromasa Yabe, Tomoo Osumi, Minako Mori, Miharu Yabe, Michael R. G. Hodskinson, Minoru Takata, Hideki Muramatsu, Lucas B. Pontel, Seishi Ogawa, Toshinori Moriguchi, Christopher L. Millington, Yusuke Okamoto, Masayuki Kobayashi, Yuichi Shiraishi, Meng Wang, Ketan J. Patel, Frederic Langevin, Berthold Göttgens, Yusuke Okuno, Sam Watcham, Felix A. Dingler, Rebecca Cordell, Keitaro Matsuo, Nina Oberbeck, Anfeng Mu
Publikováno v:
Molecular Cell
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Summary Reactive aldehydes arise as by-products of metabolism and are normally cleared by multiple families of enzymes. We find that mice lacking two aldehyde detoxifying enzymes, mitochondrial ALDH2 and cytoplasmic ADH5, have greatly shortened lifes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79d65d6f96b03ddf58df2484332f40f7
http://hdl.handle.net/2433/255881
http://hdl.handle.net/2433/255881
Autor:
James Lok Chi Che, David G. Kent, Theodoros I. Roumeliotis, Berthold Göttgens, Sam Watcham, Daniel Bode, Craig McDonald, Miriam Belmonte, Jyoti S. Choudhary
Publikováno v:
Experimental Hematology. 88:S38
De-regulation of cell fate choices in adult stem cells has been implicated in ageing and tumorigenesis. Recent advances in single cell technologies have equipped researchers with unprecedented resolution of both the functional properties and transcri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::472864dae77e07d440efaec06b5d1a6c
https://doi.org/10.1016/j.exphem.2020.09.025
https://doi.org/10.1016/j.exphem.2020.09.025
Autor:
David G. Kent, Mairi Shepherd, Daniel Prins, Rebecca Hannah, Nicola K. Wilson, Anthony R. Green, Berthold Göttgens, Katherine Sturgess, Sam Watcham
Publikováno v:
Experimental Hematology. 88:S83
Hematopoietic stem and progenitor cells (HSPCs) maintain the adult blood system, and their dysregulation is linked to multitude of disease. Jak2V617F and Tet2 mutations are known to collaboratively lead to the formation of myeloproliferative disorder
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e771a04fdb0d177e250a36223bb3e885
https://doi.org/10.1016/j.exphem.2020.09.152
https://doi.org/10.1016/j.exphem.2020.09.152
Autor:
Bertie Gottgens, Kira Glatzel, Nicola Ruivo, Andrew M. Blagborough, Alexander Lipien, Sam Watcham, Cristina Lo Celso, Sara Gonzalez Anton, Myriam L. R. Haltalli
Publikováno v:
Experimental Hematology. 64:S70
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c59706bd9fde1f86c2081baade50af99
https://doi.org/10.1016/j.exphem.2018.06.239
https://doi.org/10.1016/j.exphem.2018.06.239