Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Sam Walcott"'
Autor:
Andrew T. Lombardo, Shane R. Nelson, M. Yusuf Ali, Guy G. Kennedy, Kathleen M. Trybus, Sam Walcott, David M. Warshaw
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Cellular cargo transported along actin filaments is faced with a directional choice at an intersection. Here the authors show that myosin Va-bound cargo prefers to go straight through the intersection, and propose a model to explain this by a tug-of-
Externí odkaz:
https://doaj.org/article/9cbbb6d752f74a68bb343e25f12b6f66
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract For muscles to effectively power locomotion, trillions of myosin molecules must rapidly attach and detach from the actin thin filament. This is accomplished by precise regulation of the availability of the myosin binding sites on actin (i.e.
Externí odkaz:
https://doaj.org/article/091849787be54845a0c1a0d42faf0dc2
Autor:
Sam Walcott, Neil M Kad
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 11, p e1004599 (2015)
Muscle contracts due to ATP-dependent interactions of myosin motors with thin filaments composed of the proteins actin, troponin, and tropomyosin. Contraction is initiated when calcium binds to troponin, which changes conformation and displaces tropo
Externí odkaz:
https://doaj.org/article/b3bf72f0402c4b62ae8e3f56b1d74c0d
Autor:
Brandon M. Bensel, Samantha B. Previs, Carol S. Bookwalter, Sam Walcott, Kathleen M. Trybus, David M. Warshaw
Publikováno v:
Biophysical Journal. 122:270a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bb624cc856888a9fdc9c26ad8e1d971
https://doi.org/10.1016/j.bpj.2022.11.1543
https://doi.org/10.1016/j.bpj.2022.11.1543
Autor:
Sam Walcott, Shuyue Liu, Christopher Marang, Mike Woodward, Venus Joumaa, Tim Leonard, Brent Scott, Edward P. Debold, Walter Herzog
Publikováno v:
Biophysical Journal. 122:29a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::589f41dd74877acfea4b2395e2461fea
https://doi.org/10.1016/j.bpj.2022.11.377
https://doi.org/10.1016/j.bpj.2022.11.377
Autor:
Sam Walcott, David M. Warshaw
Myosin Va (myoVa) motors transport membrane-bound cargo through three-dimensional, intracellular actin filament networks. We developed a coarse-grained, in silico model to predict how actin filament density (3-800 filaments) within a randomly oriente
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98712710749c71daa0442cc891171ec3
https://doi.org/10.1101/2021.08.10.455842
https://doi.org/10.1101/2021.08.10.455842
Publikováno v:
Am J Physiol Cell Physiol
The hyperbolic shape of the muscle force-velocity relationship (FVR) is characteristic of all muscle fiber types. The degree of curvature of the hyperbola varies between muscle fiber types and is thought to be set by force-dependent properties of dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef09ae0479de981b10c33b429d431b09
https://doi.org/10.1152/ajpcell.00494.2018
https://doi.org/10.1152/ajpcell.00494.2018
Autor:
Kathleen M. Trybus, Sam Walcott, David M. Warshaw, Shane R. Nelson, Guy G. Kennedy, Andrew T. Lombardo
Publikováno v:
Proceedings of the National Academy of Sciences. 116:8326-8335
The cell's dense three-dimensional (3D) actin filament network presents numerous challenges to vesicular transport by teams of myosin Va (MyoVa) molecular motors. These teams must navigate their cargo through diverse actin structures ranging from Arp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41151364c48e321c56a95390e21a8e7e
https://doi.org/10.1073/pnas.1901176116
https://doi.org/10.1073/pnas.1901176116
Publikováno v:
Arch Biochem Biophys
Muscle contraction is a fundamental biological process where molecular interactions between the myosin molecular motor and actin filaments result in contraction of a whole muscle, a process spanning size scales differing in eight orders of magnitude.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e74e286830ff0b057a296314178d2231
https://europepmc.org/articles/PMC7986577/
https://europepmc.org/articles/PMC7986577/
Autor:
Sam Walcott, Guy G. Kennedy, Kathleen M. Trybus, Shane R. Nelson, David M. Warshaw, Andrew T. Lombardo, M. Yusuf Ali
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Nature Communications
Nature Communications
Intracellular cargo transport relies on myosin Va molecular motor ensembles to travel along the cell's three-dimensional (3D) highway of actin filaments. At actin filament intersections, the intersecting filament is a structural barrier to and an alt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f079055d88c3ae6a1276fbf43bbc58cd
https://doaj.org/article/9cbbb6d752f74a68bb343e25f12b6f66
https://doaj.org/article/9cbbb6d752f74a68bb343e25f12b6f66