Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Sam Virtue"'
Autor:
Jake P Mann, Xiaowen Duan, Satish Patel, Luis Carlos Tábara, Fabio Scurria, Anna Alvarez-Guaita, Afreen Haider, Ineke Luijten, Matthew Page, Margherita Protasoni, Koini Lim, Sam Virtue, Stephen O'Rahilly, Martin Armstrong, Julien Prudent, Robert K Semple, David B Savage
Publikováno v:
eLife, Vol 12 (2023)
Mitochondrial dysfunction has been reported in obesity and insulin resistance, but primary genetic mitochondrial dysfunction is generally not associated with these, arguing against a straightforward causal relationship. A rare exception, recently ide
Externí odkaz:
https://doaj.org/article/10fcb30f48a744fd966e20290cf355fb
Autor:
Ionel Sandovici, Constanze M. Hammerle, Sam Virtue, Yurena Vivas-Garcia, Adriana Izquierdo-Lahuerta, Susan E. Ozanne, Antonio Vidal-Puig, Gema Medina-Gómez, Miguel Constância
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract When exposed to nutrient excess and insulin resistance, pancreatic β-cells undergo adaptive changes in order to maintain glucose homeostasis. The role that growth control genes, highly expressed in early pancreas development, might exert in
Externí odkaz:
https://doaj.org/article/418fc450d39f40d4b1305155c0e3ac81
Macrophage beta2-adrenergic receptor is dispensable for the adipose tissue inflammation and function
Autor:
Kasparas Petkevicius, Guillaume Bidault, Sam Virtue, Stephen A. Newland, Martin Dale, Aurelien Dugourd, Julio Saez-Rodriguez, Ziad Mallat, Antonio Vidal-Puig
Publikováno v:
Molecular Metabolism, Vol 48, Iss , Pp 101220- (2021)
Objective: Neuroimmune interactions between the sympathetic nervous system (SNS) and macrophages are required for the homeostasis of multiple tissues, including the adipose tissue. It has been proposed that the SNS maintains adipose tissue macrophage
Externí odkaz:
https://doaj.org/article/43fac836b1c44a4ea72e2508bfc56a08
Autor:
Caroline Araiz, Anqi Yan, Lucia Bettedi, Isabella Samuelson, Sam Virtue, Anne K. McGavigan, Christian Dani, Antonio Vidal-Puig, Lazaros C. Foukas
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Insulin/IGF-1 signalling plays an important role in the regulation of metabolism and ageing. Here the authors show that inactivation of the pathway component PI3K p110α in the adipose tissue of mice produces a beneficial metabolic effect by enhancin
Externí odkaz:
https://doaj.org/article/f62feb23d732418d85b428408797a4db
Autor:
Albert Kwok, Ilona Zvetkova, Sam Virtue, Ineke Luijten, Isabel Huang-Doran, Patsy Tomlinson, David A. Bulger, James West, Steven Murfitt, Julian Griffin, Rafeah Alam, Daniel Hart, Rachel Knox, Peter Voshol, Antonio Vidal-Puig, Jørgen Jensen, Stephen O'Rahilly, Robert K. Semple
Publikováno v:
Molecular Metabolism, Vol 40, Iss , Pp 101020- (2020)
Objective: Insulin signalling via phosphoinositide 3-kinase (PI3K) requires PIK3R1-encoded regulatory subunits. C-terminal PIK3R1 mutations cause SHORT syndrome, as well as lipodystrophy and insulin resistance (IR), surprisingly without fatty liver o
Externí odkaz:
https://doaj.org/article/82f6d95279d840059ee0a0ab5c79af2b
Autor:
Deniz Senyilmaz-Tiebe, Daniel H. Pfaff, Sam Virtue, Kathrin V. Schwarz, Thomas Fleming, Sandro Altamura, Martina U. Muckenthaler, Jürgen G. Okun, Antonio Vidal-Puig, Peter Nawroth, Aurelio A. Teleman
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Dietary fatty acids have different effects on human health. Here, the authors show that ingestion of the fatty acid C18:0, but not of C16:0, rapidly leads to fusion of mitochondria and fatty acid oxidation in humans, possibly explaining the health be
Externí odkaz:
https://doaj.org/article/3f128c8068494e1d909d48898d9d1215
Autor:
Kasparas Petkevicius, Sam Virtue, Guillaume Bidault, Benjamin Jenkins, Cankut Çubuk, Cecilia Morgantini, Myriam Aouadi, Joaquin Dopazo, Mireille J Serlie, Albert Koulman, Antonio Vidal-Puig
Publikováno v:
eLife, Vol 8 (2019)
White adipose tissue (WAT) inflammation contributes to the development of insulin resistance in obesity. While the role of adipose tissue macrophage (ATM) pro-inflammatory signalling in the development of insulin resistance has been established, it i
Externí odkaz:
https://doaj.org/article/f5d125c747c944b4b0db66dbaee6e08b
Autor:
Caroline Araiz, Anqi Yan, Lucia Bettedi, Isabella Samuelson, Sam Virtue, Anne K. McGavigan, Christian Dani, Antonio Vidal-Puig, Lazaros C. Foukas
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/280545492a2b43cfbd5468960feae291
Publikováno v:
Frontiers in Nutrition, Vol 4 (2017)
Externí odkaz:
https://doaj.org/article/cc80dabddebc4433aa180c9c2bead2cd
Autor:
Luke K Burke, Tamana Darwish, Althea R Cavanaugh, Sam Virtue, Emma Roth, Joanna Morro, Shun-Mei Liu, Jing Xia, Jeffrey W Dalley, Keith Burling, Streamson Chua, Toni Vidal-Puig, Gary J Schwartz, Clémence Blouet
Publikováno v:
eLife, Vol 6 (2017)
Energy dissipation through interscapular brown adipose tissue (iBAT) thermogenesis is an important contributor to adaptive energy expenditure. However, it remains unresolved how acute and chronic changes in energy availability are detected by the bra
Externí odkaz:
https://doaj.org/article/cfa6ba77c17c4c99b02a679f8fe69bff