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Akademický článek

Dendritic calcium signals in rhesus macaque motor cortex drive an optical brain-computer interface

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)

Surface two-photon imaging of the brain cannot access somatic calcium signals of neurons from deep layers of the macaque cortex. Here, the authors present an implant and imaging system for chronic motion-stabilized two-photon imaging of dendritic cal

Externí odkaz: https://doaj.org/article/862821d7098a4f46ba50d01c4f46809e

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Akademický článek

In Vivo Interrogation of Spinal Mechanosensory Circuits

Autor: Amelia J. Christensen, Shrivats M. Iyer, Amaury François, Saurabh Vyas, Charu Ramakrishnan, Sam Vesuna, Karl Deisseroth, Grégory Scherrer, Scott L. Delp

Publikováno v: Cell Reports, Vol 17, Iss 6, Pp 1699-1710 (2016)

Spinal dorsal horn circuits receive, process, and transmit somatosensory information. To understand how specific components of these circuits contribute to behavior, it is critical to be able to directly modulate their activity in unanesthetized in v

Externí odkaz: https://doaj.org/article/e897a05e89ac4a5d94efcdeb77716b10

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Deep posteromedial cortical rhythm in dissociation

Autor: Paul Nuyujukian, Josef Parvizi, Tomiko Oskotsky, Sam Vesuna, Ethan B. Richman, Jaimie M. Henderson, Liqun Luo, Felicity Gore, Robert C. Malenka, Karl Deisseroth, Isaac Kauvar, Clara Sava-Segal

Publikováno v: Nature, vol 586, iss 7827
Nature

Advanced imaging methods now allow cell-type-specific recording of neural activity across the mammalian brain, potentially enabling the exploration of how brain-wide dynamical patterns give rise to complex behavioural states1–12. Dissociation is an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32b9815289eedf314209542950b9de11
https://doi.org/10.1038/s41586-020-2731-9

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Dendritic calcium signals in rhesus macaque motor cortex drive an optical brain-computer interface

Publikováno v: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)

Calcium imaging is a powerful tool for recording from large populations of neurons in vivo. Imaging in rhesus macaque motor cortex can enable the discovery of fundamental principles of motor cortical function and can inform the design of next generat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081866091d7a6378023ee1d410127b0a
https://doi.org/10.1038/s41467-021-23884-5

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Cell-type-specific population dynamics of diverse reward computations

Autor: Emily L. Sylwestrak, YoungJu Jo, Sam Vesuna, Xiao Wang, Blake Holcomb, Rebecca H. Tien, Doo Kyung Kim, Lief Fenno, Charu Ramakrishnan, William E. Allen, Ritchie Chen, Krishna V. Shenoy, David Sussillo, Karl Deisseroth

Publikováno v: Cell. 185(19)

Computational analysis of cellular activity has developed largely independently of modern transcriptomic cell typology, but integrating these approaches may be essential for full insight into cellular-level mechanisms underlying brain function and dy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ba84af4478fbc2e664a807167f3f784
https://pubmed.ncbi.nlm.nih.gov/36113428

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Comprehensive dual- and triple-feature intersectional single-vector delivery of diverse functional payloads to cells of behaving mammals

Autor: Kathy Y.M. Cheung, Charu Ramakrishnan, Yoon Seok Kim, Alice S. O. Hong, Nandini Pichamoorthy, Elle Yuen, Masatoshi Inoue, Maisie Lo, Sam Vesuna, Lief E. Fenno, Karl Deisseroth, Kathryn E. Evans

Publikováno v: Neuron

Both the resolution and dimensionality with which biologists can characterize cell types have expanded dramatically in recent years, and intersectional consideration of such features (e.g. multiple gene-expression and anatomical parameters) is increa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c67d75947deaaeac16086902092f099f
https://europepmc.org/articles/PMC7687746/

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Three-dimensional intact-tissue sequencing of single-cell transcriptional states

Autor: Matthew Wright, Sam Vesuna, Cindy Zang Liu, Emily L. Sylwestrak, Karl Deisseroth, Charu Ramakrishnan, Felice-Alessio Bava, Kathryn E. Evans, William E. Allen, Xiao Wang, Garry P. Nolan, Nikolay Samusik, Jia Liu

Publikováno v: Science. 361

Transcriptome mapping in the 3D brain RNA sequencing samples the entire transcriptome but lacks anatomical information. In situ hybridization, on the other hand, can only profile a small number of transcripts. In situ sequencing technologies address

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3c9396fcd66602757cee1118e4e8ed5
https://doi.org/10.1126/science.aat5691

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