Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Sam Vanherle"'
Autor:
Melanie Loix, Sam Vanherle, Marta Turri, Stephan Kemp, Karl J. L. Fernandes, Jerome J. A. Hendriks, Jeroen F. J. Bogie
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-15 (2024)
Abstract Disturbances in the fatty acid lipidome are increasingly recognized as key drivers in the progression of various brain disorders. In this review article, we delve into the impact of Δ9 fatty acid desaturases, with a particular focus on stea
Externí odkaz:
https://doaj.org/article/d0cd345d6a534169b3d87a3b0071d96d
Autor:
Sam Vanherle, Jeroen Guns, Melanie Loix, Fleur Mingneau, Tess Dierckx, Flore Wouters, Koen Kuipers, Tim Vangansewinkel, Esther Wolfs, Paula Pincela Lins, Annelies Bronckaers, Ivo Lambrichts, Jonas Dehairs, Johannes V. Swinnen, Sanne G. S. Verberk, Mansour Haidar, Jerome J. A. Hendriks, Jeroen F. J. Bogie
Publikováno v:
Journal of Extracellular Vesicles, Vol 12, Iss 12, Pp n/a-n/a (2023)
Abstract Macrophages play major roles in the pathophysiology of various neurological disorders, being involved in seemingly opposing processes such as lesion progression and resolution. Yet, the molecular mechanisms that drive their harmful and benig
Externí odkaz:
https://doaj.org/article/a6e816db044d4b4cb16b68a2c6586fad
Autor:
Tess Dierckx, Mansour Haidar, Elien Grajchen, Elien Wouters, Sam Vanherle, Melanie Loix, Annick Boeykens, Dany Bylemans, Kévin Hardonnière, Saadia Kerdine-Römer, Jeroen F. J. Bogie, Jerome J. A. Hendriks
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-15 (2021)
Abstract Background Macrophages play a dual role in neuroinflammatory disorders such as multiple sclerosis (MS). They are involved in lesion onset and progression but can also promote the resolution of inflammation and repair of damaged tissue. In th
Externí odkaz:
https://doaj.org/article/a5263a25384c45e78a99d4b06ce71e49
Publikováno v:
Cells, Vol 11, Iss 3, p 565 (2022)
Macrophages are present in all tissues within our body, where they promote tissue homeostasis by responding to microenvironmental triggers, not only through clearance of pathogens and apoptotic cells but also via trophic, regulatory, and repair funct
Externí odkaz:
https://doaj.org/article/a762dbc73e5d4e888e4ece587ae7b24f
Autor:
Elien Grajchen, Melanie Loix, Paulien Baeten, Beatriz F. Côrte-Real, Ibrahim Hamad, Sam Vanherle, Mansour Haidar, Jonas Dehairs, Jelle Y. Broos, James M. Ntambi, Robert Zimmermann, Rolf Breinbauer, Piet Stinissen, Niels Hellings, Sanne G. S. Verberk, Gijs Kooij, Martin Giera, Johannes V. Swinnen, Bieke Broux, Markus Kleinewietfeld, Jerome J. A. Hendriks, Jeroen F. J. Bogie
Publikováno v:
Cellular and Molecular Immunology, 20(6), 666-679. Nature Publishing Group
Grajchen, E, Loix, M, Baeten, P, Côrte-Real, B F, Hamad, I, Vanherle, S, Haidar, M, Dehairs, J, Broos, J Y, Ntambi, J M, Zimmermann, R, Breinbauer, R, Stinissen, P, Hellings, N, Verberk, S G S, Kooij, G, Giera, M, Swinnen, J V, Broux, B, Kleinewietfeld, M, Hendriks, J J A & Bogie, J F J 2023, ' Fatty acid desaturation by stearoyl-CoA desaturase-1 controls regulatory T cell differentiation and autoimmunity ', Cellular and Molecular Immunology, vol. 20, no. 6, pp. 666-679 . https://doi.org/10.1038/s41423-023-01011-2
Grajchen, E, Loix, M, Baeten, P, Côrte-Real, B F, Hamad, I, Vanherle, S, Haidar, M, Dehairs, J, Broos, J Y, Ntambi, J M, Zimmermann, R, Breinbauer, R, Stinissen, P, Hellings, N, Verberk, S G S, Kooij, G, Giera, M, Swinnen, J V, Broux, B, Kleinewietfeld, M, Hendriks, J J A & Bogie, J F J 2023, ' Fatty acid desaturation by stearoyl-CoA desaturase-1 controls regulatory T cell differentiation and autoimmunity ', Cellular and Molecular Immunology, vol. 20, no. 6, pp. 666-679 . https://doi.org/10.1038/s41423-023-01011-2
The imbalance between pathogenic and protective T cell subsets is a cardinal feature of autoimmune disorders such as multiple sclerosis (MS). Emerging evidence indicates that endogenous and dietary-induced changes in fatty acid metabolism have a majo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0453077196c63a160f7fb022361b2740
https://cris.maastrichtuniversity.nl/en/publications/91c2f0c1-489d-4001-92ff-b59bf00eacea
https://cris.maastrichtuniversity.nl/en/publications/91c2f0c1-489d-4001-92ff-b59bf00eacea
Autor:
Mansour Haidar, Melanie Loix, Sam Vanherle, Tess Dierckx, Tim Vangansewinkel, Pascal Gervois, Esther Wolfs, Ivo Lambrichts, Jeroen F.J. Bogie, Jerome J.A. Hendriks
Publikováno v:
Autophagy
Foamy macrophages containing abundant intracellular myelin remnants are an important pathological hallmark of multiple sclerosis. Reducing the intracellular lipid burden in foamy macrophages is considered a promising therapeutic strategy to induce a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d882da3eeaea280ad99303c81d247483
https://doi.org/10.1080/15548627.2022.2047343
https://doi.org/10.1080/15548627.2022.2047343
Autor:
Sam Vanherle, Jeroen Guns, Melanie Loix, Fleur Mingneau, Tess Dierckx, Tim Vangansewinkel, Esther Wolfs, Paula Pincela Lins, Annelies Bronckaers, Ivo Lambrichts, Jonas Dehairs, Johannes V. Swinnen, Sanne G.S. Verberk, Mansour Haidar, Jerome J.A. Hendriks, Jeroen F.J. Bogie
Macrophages play major roles in the pathophysiology of various neurological disorders, being involved in seemingly opposing processes such as lesion progression and resolution. Yet, the molecular mechanisms that drive their harmful and benign effecto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99b120ea3d280c88a5f9ab4c9c9f6f88
https://doi.org/10.1101/2022.12.23.521775
https://doi.org/10.1101/2022.12.23.521775
Autor:
Tess Dierckx, Sam Vanherle, Mansour Haidar, Elien Grajchen, Fleur Mingneau, Pascal Gervois, Esther Wolfs, Dany Bylemans, Arnout Voet, Tien Nguyen, Ibrahim Hamad, Markus Kleinewietfeld, Jeroen F. J. Bogie, Jerome J. A. Hendriks
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Failure of remyelination underlies the progressive nature of demyelinating diseases such as multiple sclerosis. Why endogenous repair mechanisms frequently fail in these disorders is poorly understood. However, there is now evidence indicating that t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f024a9bb3e5f1f919c32faaa47810597
https://doi.org/10.1073/pnas.2120393119
https://doi.org/10.1073/pnas.2120393119
Autor:
Melanie Loix, Elien Wouters, Sam Vanherle, Jonas Dehairs, James L. McManaman, Hannelore Kemps, Johannes V. Swinnen, Mansour Haidar, Jeroen F. J. Bogie, Jerome J. A. Hendriks
Publikováno v:
Cellular and molecular life sciences : CMLS. 79(10)
Foamy macrophages and microglia containing lipid droplets (LDs) are a pathological hallmark of demyelinating disorders affecting the central nervous system (CNS). We and others showed that excessive accumulation of intracellular lipids drives these p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66bae9b5fb0b2fc17c0a9ac4aaeef635
https://pubmed.ncbi.nlm.nih.gov/36100764
https://pubmed.ncbi.nlm.nih.gov/36100764
Autor:
Sam Vanherle, Winde Jorissen, Tess Dierckx, Melanie Loix, Elien Grajchen, Fleur Mingneau, Jeroen Guns, Pascal Gervois, Ivo Lambrichts, Jonas Dehairs, Johannes V. Swinnen, Monique T. Mulder, Alan T. Remaley, Mansour Haidar, Jerome J.A. Hendriks, Jeroen J.F. Bogie
Publikováno v:
Cell Reports, 41(6):111591. Cell Press
The progressive nature of demyelinating diseases lies in the inability of the central nervous system (CNS) to induce proper remyelination. Recently, we and others demonstrated that a dysregulated innate immune response partially underlies failure of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a987079cca7a30d80a99841aa1e71327
https://doi.org/10.1016/j.celrep.2022.111591
https://doi.org/10.1016/j.celrep.2022.111591