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Detection of pepsin in mouth swab: correlation with clinical gastroesophageal reflux in preterm infants

Autor: Barbara Amendolia, Zhaoping He, Kee H. Pyon, Dev Mehta, Vishwanath Bhat, Sam Soundar, Judy G. Saslow, Gary Stahl, Zubair H. Aghai, Sabeena Farhath

Publikováno v: The Journal of Maternal-Fetal & Neonatal Medicine. 26:819-824

To study the relationship between pepsinogen/pepsin in a mouth swab and clinical gastroesophageal reflux (GER) in preterm infants.Preterm infants (birth weight ≤ 2000 g) on full enteral feeds were enrolled. Mouth swabs from cheek and below the tong

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10d228f1d4e106894a29717f19f5323f
https://doi.org/10.3109/14767058.2013.764408

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A pilot randomized clinical trial assessing the effect of cricoid pressure on risk of aspiration

Autor: Augustine S. Lee, J. Kyle Bohman, Sam Soundar, Laura Bolling, Zhaoping He, Daryl J. Kor, Rahul Kashyap

Publikováno v: The clinical respiratory journal. 12(1)

Introduction Patients at risk for microaspiration during elective intubation often receive cricoid pressure in the hopes of mitigating such risk. However, there is scarce evidence to either support or reject this practice. The objective of this inves

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7607f447e45dfe18622ca64af24610d
https://pubmed.ncbi.nlm.nih.gov/27273863

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The Role of Extraesophageal Reflux in Otitis Media in Infants and Children

Autor: Ellen S. Deutsch, Patrick Barth, Steven P. Cook, Sam Soundar, Laura Bolling, Zhaoping He, Blake Papsin, Richard J. Schmidt, James S. Reilly, Esa Bloedon, Robert C. O’Reilly, Larry B. Lundy, Devendra I. Mehta

Publikováno v: The Laryngoscope. 118:1-9

Objectives/Hypothesis: Gastroesophageal reflux disease (GERD) is common in children, and extraesophageal reflux disease (EORD) has been implicated in the pathophysiology of otitis media (OM). We sought to 1) determine the incidence of pepsin/pepsinog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33d4d4cbf61c90fb9ce4fb553b8bfe6a
https://doi.org/10.1097/mlg.0b013e31817924a3

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Assessment of the prevalence of microaspiration by gastric pepsin in the airway of ventilated children

Autor: Scott Penfil, Mansi Shah, Devendra I. Mehta, John J. McCloskey, Sam Soundar, Vani V. Gopalareddy, Laura Bolling, Zhaoping He

Publikováno v: Acta Paediatrica. 97:55-60

Aim: Mechanically ventilated patients are at risk for aspiration of gastric contents. The aim of this observational study was to determine the prevalence of micro-aspiration in children with cuffed and uncuffed endotracheal (ET) tubes and with trache

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::573325466a56a215925208b809e20150
https://doi.org/10.1111/j.1651-2227.2007.00578.x

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Detection of Gastric Pepsin in Middle Ear Fluid of Children with Otitis Media

Autor: Richard J. Schmidt, Sam Soundar, Esa Bloedon, Steven P. Cook, Mansi Shah, Robert C. O’Reilly, Devendra I. Mehta, Laura Bolling, Zhaoping He

Publikováno v: Otolaryngology–Head and Neck Surgery. 137:59-64

Objective We sought to confirm the finding of pepsin/pepsinogen in the middle ear fluid of children with otitis media in a larger sample size using a sensitive and specific pepsin assay. Study Design and Setting We evaluated 152 children (225 ear sam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462e9154e1c54d022b4329dff7498742
https://doi.org/10.1016/j.otohns.2007.02.002

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The role of gastric pepsin in the inflammatory cascade of pediatric otitis media

Autor: Tracey Nadal, Sam Soundar, Laura Bolling, Zhaoping He, Estelle Yoo, Robert C. O’Reilly, Erin Field, Dalal Tonb, Christopher Grindle

Publikováno v: JAMA otolaryngology-- headneck surgery. 141(4)

Otitis media is characterized as an ongoing inflammation with accumulation of an effusion in the middle ear cleft. The molecular mechanisms underlying the pathogenesis, particularly the inflammatory response, remain largely unknown. We hypothesize th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d062ae567e72e7aac58bd21ccc08fac7
https://pubmed.ncbi.nlm.nih.gov/25633964

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Pepsin, a marker of gastric contents, is increased in tracheal aspirates from preterm infants who develop bronchopulmonary dysplasia

Autor: Devendra I. Mehta, Jeanette Camacho, Judy G. Saslow, Sabeena Farhath, Zhaoping He, Stephen Shaffer, Sam Soundar, Gary Stahl, Zubair H. Aghai, Tarek Nakhla

Publikováno v: Pediatrics. 121(2)

OBJECTIVE. The objective of this study was to study the association between pepsin in tracheal aspirate samples and the development of bronchopulmonary dysplasia in preterm infants. METHODS. Serial tracheal aspirate samples were collected during the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeb4196ce9c06777d1aa8d368f2cae89
https://pubmed.ncbi.nlm.nih.gov/18245400

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Assessment of the prevalence of microaspiration by gastric pepsin in the airway of ventilated children

Autor: Vani, Gopalareddy, Zhaoping, He, Sam, Soundar, Laura, Bolling, Mansi, Shah, Scott, Penfil, John J, McCloskey, Devendra I, Mehta

Publikováno v: Acta paediatrica (Oslo, Norway : 1992). 97(1)

Mechanically ventilated patients are at risk for aspiration of gastric contents. The aim of this observational study was to determine the prevalence of micro-aspiration in children with cuffed and uncuffed endotracheal (ET) tubes and with tracheostom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b008d4c64b5fe2edd1d8a1fc9c9eb643
https://pubmed.ncbi.nlm.nih.gov/18076720

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