Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Sam Singer"'
Autor:
Juan Yan, Yuedan Chen, Amish J. Patel, Sarah Warda, Cindy J. Lee, Briana G. Nixon, Elissa W.P. Wong, Miguel A. Miranda-Román, Ning Yang, Yi Wang, Mohini R. Pachai, Jessica Sher, Emily Giff, Fanying Tang, Ekta Khurana, Sam Singer, Yang Liu, Phillip M. Galbo Jr., Jesper L.V. Maag, Richard P. Koche, Deyou Zheng, Cristina R. Antonescu, Liang Deng, Ming O. Li, Yu Chen, Ping Chi
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 17 (2022)
Immune checkpoint blockade (ICB) has demonstrated clinical success in “inflamed” tumors with substantial T cell infiltrates, but tumors with an immune-desert tumor microenvironment (TME) fail to benefit. The tumor cell–intrinsic molecular mecha
Externí odkaz:
https://doaj.org/article/5f861c04fcd24ec597718aa39450c410
Autor:
Michele L. Donato, Steven Park, Melissa Baker, Robert Korngold, Alison Morawski, Xue Geng, Ming Tan, Andrew Ip, Stuart Goldberg, Scott Rowley, Kar Chow, Emily Brown, Joshua Zenreich, Phyllis McKiernan, Kathryn Buttner, Anna Ullrich, Laura Long, Rena Feinman, Andrea Ricourt, Marlo Kemp, Mariefel Vendivil, Hyung Suh, Bindu Balani, Cristina Cicogna, Rani Sebti, Abdulla Al-Khan, Steven Sperber, Samit Desai, Stacey Fanning, Danit Arad, Ronaldo Go, Elizabeth Tam, Keith Rose, Sean Sadikot, David Siegel, Martin Gutierrez, Tatyana Feldman, Andre Goy, Andrew Pecora, Noa Biran, Lori Leslie, Alfred Gillio, Sarah Timmapuri, Michele Boonstra, Sam Singer, Sukhdeep Kaur, Ernest Richards, David S. Perlin
Publikováno v:
JCI Insight, Vol 6, Iss 6 (2021)
Here, we report on a phase IIa study to determine the intubation rate, survival, viral clearance, and development of endogenous Abs in patients with COVID-19 pneumonia treated with convalescent plasma (CCP) containing high levels of neutralizing anti
Externí odkaz:
https://doaj.org/article/4105869b8be542f7861f13287a3a1652
Autor:
Sam Singer
Publikováno v:
PLoS Medicine, Vol 4, Iss 1, p e51; author reply e44 (2007)
Externí odkaz:
https://doaj.org/article/010018a268254fd5923eab87d0c18d4b
Autor:
Gary K. Schwartz, Li-Xuan Qin, Naoko Takebe, William D. Tap, Sam Singer, Aimee M. Crago, Robert A. Lefkowitz, Moriah Martindale, Meera R. Hameed, Narasimhan Agaram, Cristina R. Antonescu, Joseph P. Erinjeri, Mary Lou Keohan, Ping Chi, Sandra P. D'Angelo, Tahir N. Sheikh, Mark A. Dickson, Nian Wu, Evan Rosenbaum, Mrinal M. Gounder
Purpose:Because the Hedgehog and Notch pathways are often overexpressed in mesenchymal malignancies, we evaluated the efficacy of concurrent inhibition of Notch and Hedgehog signaling using the gamma-secretase inhibitor (GSI) RO4929097 and the smooth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b51ea3a988bee341cdb569be8e5fdfcf
https://doi.org/10.1158/1078-0432.c.6532617
https://doi.org/10.1158/1078-0432.c.6532617
Autor:
Gary K. Schwartz, Li-Xuan Qin, Naoko Takebe, William D. Tap, Sam Singer, Aimee M. Crago, Robert A. Lefkowitz, Moriah Martindale, Meera R. Hameed, Narasimhan Agaram, Cristina R. Antonescu, Joseph P. Erinjeri, Mary Lou Keohan, Ping Chi, Sandra P. D'Angelo, Tahir N. Sheikh, Mark A. Dickson, Nian Wu, Evan Rosenbaum, Mrinal M. Gounder
Supplementary Data from A Phase Ib/II Randomized Study of RO4929097, a Gamma-Secretase or Notch Inhibitor with or without Vismodegib, a Hedgehog Inhibitor, in Advanced Sarcoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::717e6543c9369e97ed1ab5041b73a64c
https://doi.org/10.1158/1078-0432.22487940.v1
https://doi.org/10.1158/1078-0432.22487940.v1
Autor:
Mrinal M. Gounder, Evan Rosenbaum, Nian Wu, Mark A. Dickson, Tahir N. Sheikh, Sandra P. D'Angelo, Ping Chi, Mary Lou Keohan, Joseph P. Erinjeri, Cristina R. Antonescu, Narasimhan Agaram, Meera R. Hameed, Moriah Martindale, Robert A. Lefkowitz, Aimee M. Crago, Sam Singer, William D. Tap, Naoko Takebe, Li-Xuan Qin, Gary K. Schwartz
Publikováno v:
Clin Cancer Res
Purpose: Because the Hedgehog and Notch pathways are often overexpressed in mesenchymal malignancies, we evaluated the efficacy of concurrent inhibition of Notch and Hedgehog signaling using the gamma-secretase inhibitor (GSI) RO4929097 and the smoot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c0f7dc0f5b2ee00a9176021db8e9f8
https://doi.org/10.1158/1078-0432.ccr-21-3874
https://doi.org/10.1158/1078-0432.ccr-21-3874
Autor:
Juan Yan, Yuedan Chen, Amish J. Patel, Sarah Warda, Briana G. Nixon, Elissa W.P. Wong, Miguel A. Miranda-Román, Cindy J. Lee, Ning Yang, Yi Wang, Jessica Sher, Emily Giff, Fanying Tang, Ekta Khurana, Sam Singer, Yang Liu, Phillip M. Galbo, Jesper L. Maag, Richard P. Koche, Deyou Zheng, Liang Deng, Cristina R. Antonescu, Ming Li, Yu Chen, Ping Chi
Immune checkpoint blockade (ICB) has demonstrated clinical success in “inflamed” tumors with significant T-cell infiltrates, but tumors with an immune-desert tumor microenvironment (TME) fail to benefit. The tumor cell-intrinsic molecular mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c3e30d42629a5df69dc99352a3c9ef0
https://doi.org/10.1101/2022.05.27.493507
https://doi.org/10.1101/2022.05.27.493507
Autor:
Jason E. Chan, Jonathan Rub, Carleigh Sussman, Olivera Grbovic-huezo, William D. Tap, Cristina Antonescu, Sam Singer, Doron Betel, Tuomas Tammela
Publikováno v:
Clinical Cancer Research. 28:B008-B008
Undifferentiated soft tissue sarcomas (USTS) are an aggressive class of sarcomas with few effective treatment options. Because of the rarity of these sarcomas and the paucity of representative disease models, little is known about how they develop. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6faa6cb50134d38b85dd28278ceccc5
https://doi.org/10.1158/1557-3265.sarcomas22-b008
https://doi.org/10.1158/1557-3265.sarcomas22-b008
Autor:
Juan Yan, Yuedan Chen, Amish J. Patel, Sarah Warda, Cindy J. Lee, Briana G. Nixon, Elissa W.P. Wong, Miguel A. Miranda-Román, Ning Yang, Yi Wang, Mohini R. Pachai, Jessica Sher, Emily Giff, Fanying Tang, Ekta Khurana, Sam Singer, Yang Liu, Phillip M. Galbo, Jesper L.V. Maag, Richard P. Koche, Deyou Zheng, Cristina R. Antonescu, Liang Deng, Ming O. Li, Yu Chen, Ping Chi
Publikováno v:
The Journal of clinical investigation. 132(17)
Immune checkpoint blockade (ICB) has demonstrated clinical success in "inflamed" tumors with substantial T cell infiltrates, but tumors with an immune-desert tumor microenvironment (TME) fail to benefit. The tumor cell-intrinsic molecular mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c931fb44c66ea5c53605e85e8a92e709
https://pubmed.ncbi.nlm.nih.gov/35852856
https://pubmed.ncbi.nlm.nih.gov/35852856
Autor:
Juan Yan, Yuedan Chen, Amish J. Patel, Cindy J. Lee, Sarah Warda, Briana G. Nixon, Elissa W. P. Wong, Miguel A. Miranda-Román, Ning Yang, Yi Wang, Jessica Sher, Emily Giff, Fanying Tang, Ekta Khurana, Sam Singer, Yang Liu, Phillip M. Galbo, Jesper L. Maag, Richard P. Koche, Deyou Zheng, Cristina R. Antonescu, Ming Li, Liang Deng, Yu Chen, Ping Chi
Publikováno v:
Cancer Research. 82:6164-6164
Immune checkpoint blockade (ICB) has demonstrated clinical success in “inflamed” tumors with significant T-cell infiltrates, but tumors with an immune-desert tumor microenvironment (TME) fail to benefit. The tumor cell-intrinsic molecular mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ae8c39ba3a73e2a4e838118ef88b866
https://doi.org/10.1158/1538-7445.am2022-6164
https://doi.org/10.1158/1538-7445.am2022-6164