Výsledky vyhledávání - "Sam S. K. Lee"

Origin-specific unwinding of herpes simplex virus 1 DNA by the viral UL9 and ICP8 proteins: Visualization of a specific preunwinding complex

Autor: I. Robert Lehman, Alexander M. Makhov, Jack D. Griffith, Sam S. K. Lee

Publikováno v: Proceedings of the National Academy of Sciences. 100:898-903

Herpes simplex virus 1 contains three origins of replication; two copies of oriS and one of a similar sequence, oriL. Here, the combined action of multiple factors known or thought to influence the opening of oriS are examined. These include the vira

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e59db3be52d403006e5312ce039a56e2
https://doi.org/10.1073/pnas.0237171100

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The Interaction of Herpes Simplex Type 1 Virus Origin-binding Protein (UL9 Protein) with Box I, the High Affinity Element of the Viral Origin of DNA Replication

Autor: I. R. Lehman, Sam S. K. Lee

Publikováno v: Journal of Biological Chemistry. 274:18613-18617

The herpes simplex type 1 (HSV-1) origin binding protein, the UL9 protein, exists in solution as a homodimer of 94-kDa monomers. It binds to Box I, the high affinity element of the HSV-1 origin, Oris, as a dimer. The UL9 protein also binds the HSV-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0708151efa72936ed49482b1f7d089b9
https://doi.org/10.1074/jbc.274.26.18613

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A polyphosphate kinase 1 (ppk1) mutant of Pseudomonas aeruginosa exhibits multiple ultrastructural and functional defects

Autor: M. Harunur Rashid, Janine Harrison, Rebecca J. Gottschalk, Cresson D. Fraley, Sam S. K. Lee, Arthur Kornberg, Michael R. W. Brown, Pauline J. Wood

Pseudomonas aeruginosa , of medical, environmental, and industrial importance, depends on inorganic polyphosphate (poly P) for a wide range of functions, especially survival. Mutants of PAO1 lacking poly P kinase 1, PPK1, the enzyme responsible for m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9aafa593740683be164a57df2367c3c
https://europepmc.org/articles/PMC1803759/

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Unwinding of the box I element of a herpes simplex virus type 1 origin by a complex of the viral origin binding protein, single-strand DNA binding protein, and single-stranded DNA

Autor: I. R. Lehman, Sam S. K. Lee

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 94(7)

The herpes simplex virus type 1 (HSV-1) genome contains three origins of replication: ori L and two copies of ori S . These origins contain specific sequences, box I and box II, linked by an AT-rich segment, that are recognized by an HSV-1-encoded or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::829d9098af4db33c938203ed3cb5f6d5
https://pubmed.ncbi.nlm.nih.gov/9096307

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Interaction of herpes simplex virus 1 origin-binding protein with DNA polymerase alpha

Autor: I. R. Lehman, Teresa S.-F. Wang, Sam S. K. Lee, Qun Dong

The herpes simplex virus 1 (HSV-1) genome encodes seven polypeptides that are required for its replication. These include a heterodimeric DNA polymerase, a single-strand-DNA-binding protein, a heterotrimeric helicase/primase, and a protein (UL9 prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::121b146a2ca00c4598eb75090a0d64ee
https://europepmc.org/articles/PMC41250/

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