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Patients with paroxysmal nocturnal hemoglobinuria demonstrate a prothrombotic clotting phenotype which is improved by complement inhibition with eculizumab

Autor: Fraser L. Macrae, Claire E McKinley, Emma Linton, Polly Bowman, Anita Hill, Sam Quested, Stephen R. Baker, Robert A. S. Ariëns, Barnaby Peacock-Young, Darren J. Newton, Talha Munir, Peter Hillmen, Morag Griffin, Daniel Payne, Deborah Clarke

Publikováno v: American Journal of Hematology. 95:944-952

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematological disorder, characterized by complement-mediated intravascular hemolysis and thrombosis. The increased incidence of PNH-driven thrombosis is still poorly understood, but unlike other thr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f3e51d1f5bbeb8236f1006ba103c3a2
https://doi.org/10.1002/ajh.25841

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1439 Analysis of the children’s abdominal pain pathway pre and during COVID and implementation of the paediatric appendicitis score (PAS) in the Mid-Yorkshire Trust

Autor: Fiona Costigan, Sam Quested

Publikováno v: Abstracts.

1439 Table 1Histologically positive appendectomies and PAS interpretationHistologically positive and PAS PRE-Covid Post-initial wave Total 0–2 0 0 0 3–6 1 (100%) 2 (66.7%) 3 (75%) 7+ 5 (100%) 13 (92.3%) 18 (94.5%) Not adhered 3 (75%) 4 (100%) 7 (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7226e747441ece30bd10e159922ad92
https://doi.org/10.1136/archdischild-2021-rcpch.644

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