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Metabolomics of Prostate Cancer Gleason Score in Tumor Tissue and Serum

Autor: Michelangelo Fiorentino, Mark Pomerantz, Giorgia Zadra, Hannah Coulson, Jacob Rosenthal, Giuseppe Nicolò Fanelli, Ryan Carelli, Sam Peisch, Renato Umeton, Habiba El Fandy, Massimo Loda, Rosina T. Lis, Stephanie Borgstein, Svitlana Tyekucheva, Kathryn L. Penney, Adam S. Kibel, Francesca Giunchi, Lavinia Stefanizzi

Publikováno v: Mol Cancer Res

Gleason score, a measure of prostate tumor differentiation, is the strongest predictor of lethal prostate cancer at the time of diagnosis. Metabolomic profiling of tumor and of patient serum could identify biomarkers of aggressive disease and lead to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32653dfc57d19f2e43c850479077e7d4
https://doi.org/10.1158/1541-7786.mcr-20-0548

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Association between Trichomonas vaginalis and prostate cancer mortality

Autor: Sam Peisch, Amparo G. Gonzalez-Feliciano, Sabrina H. Tsang, Elizabeth A. Platz, Lorelei A. Mucci, Siobhan Sutcliffe, Ericka M. Ebot, Sarah C. Markt, Brendan Rowan

Publikováno v: Int J Cancer

We previously observed a positive association between seropositivity for the parasite Trichomonas vaginalis and risk of clinically significant prostate cancer at diagnosis. Here, we examined whether T. vaginalis seropositivity was associated with inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d607d79fdedc49f131466f80ea32da
https://doi.org/10.1002/ijc.31885

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Family History of Breast or Prostate Cancer and Prostate Cancer Risk

Autor: Travis Gerke, Thomas U. Ahearn, Lauren E. Barber, Kathryn M. Wilson, Lorelei A. Mucci, Sam Peisch, Edward Giovannucci, Giovanni Parmigiani, Sarah C. Markt

Publikováno v: Clinical Cancer Research. 24:5910-5917

Purpose: Breast and prostate cancer co-occur in families, and women with a family history of prostate cancer are at increased breast cancer risk. Prostate cancer is among the most heritable cancers, but few studies have investigated its association w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7de93cce26c8c2d7b7901e842d6c987b
https://doi.org/10.1158/1078-0432.ccr-18-0370

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A Prospective Study of Aspirin Use and Prostate Cancer Risk by TMPRSS2:ERG Status

Autor: Rebecca E. Graff, Konrad H. Stopsack, Andreas Pettersson, Mary K. Downer, Sam Peisch, Stephen P. Finn, Massimo Loda, Philip W. Kantoff, Lorelei A. Mucci, Claire H. Pernar, Rosina T. Lis, Riley A. Gage, Amparo G. Gonzalez-Feliciano, Thomas U. Ahearn

Publikováno v: Cancer Epidemiology, Biomarkers & Prevention. 27:1231-1233

Background: In a case–control study, aspirin use was associated with a lower risk of a common prostate cancer molecular subtype, the TMPRSS2:ERG gene fusion. We sought to validate this finding in a prospective cohort. Methods: In the Health Profess

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::83c83e932609acbdb5a77384f1d94bfe
https://doi.org/10.1158/1055-9965.epi-18-0510

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Diversity of Enrollment in Prostate Cancer Clinical Trials: Current Status and Future Directions

Autor: Rana R. McKay, Sam Peisch, Philip W. Kantoff, Kelly Hawthorne, Lorelei A. Mucci, Stacey Simmons, Jelani C. Zarif, Daniel J. George, Paul Villanti, Adam Friedant, Franklin W. Huang, Jake Vinson, Elisabeth I. Heath, Latifa Bazzi, Emily M. Rencsok

Publikováno v: Cancer Epidemiol Biomarkers Prev

Background: Although there are considerable racial and ethnic disparities in prostate cancer incidence and mortality in the United States and globally, clinical trials often do not reflect disease incidence across racial and ethnic subgroups. This st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dec2ce607c779d4f71b161914bad6f3
https://pubmed.ncbi.nlm.nih.gov/32503813

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Baldness and Risk of Prostate Cancer in the Health Professionals Follow-up Study

Autor: Amparo G. Gonzalez-Feliciano, Edward Giovannucci, Joshua Caldwell, Sam Peisch, Kathryn M. Wilson, Lorelei A. Mucci, Sarah C. Markt, Travis Gerke, Rebecca E. Graff, Saud Khan, Claire H. Pernar

Publikováno v: Cancer Epidemiol Biomarkers Prev

Background: The association between male pattern baldness and prostate cancer has been inconsistent. We prospectively investigated the association between baldness at age 45 and prostate cancer risk in the Health Professionals Follow-up Study (HPFS),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57377bb6e6ce578dc5495537df59d137
https://pubmed.ncbi.nlm.nih.gov/32277004

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Prognostic Utility of a New mRNA Expression Signature of Gleason Score

Autor: Sam Peisch, Michelangelo Fiorentino, Kathryn L. Penney, Lorelei A. Mucci, Massimo Loda, Jennifer A. Sinnott, Jennifer R. Rider, Meir J. Stampfer, Rosina T. Lis, Svitlana Tyekucheva, Travis Gerke

Publikováno v: Clinical Cancer Research. 23:81-87

Purpose: Gleason score strongly predicts prostate cancer mortality; however, scoring varies among pathologists, and many men are diagnosed with intermediate-risk Gleason score 7. We previously developed a 157-gene signature for Gleason score using a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b2612b02cb73daacb5c9fba768a96fe
https://doi.org/10.1158/1078-0432.ccr-16-1245

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