Výsledky vyhledávání - "Sam Osseiran"

Longitudinal monitoring of cancer cell subpopulations in monolayers, 3D spheroids, and xenografts using the photoconvertible dye DiR

Autor: David M. Langenau, Taylor M. Cannon, Lauren A. Austin, Sam Osseiran, Conor L. Evans, Chuan Yan

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports

A central challenge in cancer biology is the identification, longitudinal tracking, and -omics analysis of specific cells in vivo. To this aim, photoconvertible fluorescent dyes are reporters that are characterized by a set of excitation and emission

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4893f7bb46064ae07bd40735603091ff
http://link.springer.com/article/10.1038/s41598-019-42165-2

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Neural Selective Cryoneurolysis with Ice Slurry Injection in a Rat Model

Autor: Sara Moradi Tuchayi, Martin Purschke, Sam Osseiran, R. Rox Anderson, Gary R. Strichartz, Lilit Garibyan, Jianren Mao, Alla Khodorova, Ying Wang, Anat Stemmer-Rachamimov, Conor L. Evans

Publikováno v: Anesthesiology

Background Postoperative pain caused by trauma to nerves and tissue around the surgical site is a major problem. Perioperative steps to reduce postoperative pain include local anesthetics and opioids, the latter of which are addictive and have contri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e90acbeecf989fb6b342a6b7b3c7cead
https://europepmc.org/articles/PMC7299828/

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Non-destructive two-photon excited fluorescence imaging identifies early nodules in calcific aortic-valve disease

Autor: Conor L. Evans, Lauren Baugh, Sam Osseiran, Philip W. Hinds, Irene Georgakoudi, Kyle P. Quinn, Gordon S. Huggins, Zhiyi Liu, Lauren D. Black

Publikováno v: Nature Biomedical Engineering. 1:914-924

Calcifications occur during the development of healthy bone, and at the onset of calcific aortic-valve disease (CAVD) and many other pathologies. Although the mechanisms regulating early calcium deposition are not fully understood, they may provide t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be5257a5ab1a2f1f603e12e457bd584
https://doi.org/10.1038/s41551-017-0152-3

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Fluorescence lifetime imaging microscopy along with non-Euclidean phasor analysis for visualization of drug distribution of a topical drug in human facial skin (Conference Presentation)

Autor: Tanvee Sawant, Sam Osseiran, Conor L. Evans, Alexander Fast, Sinyoung Jeong, Kin F. Chan, Maiko Hermsmeier

Publikováno v: Visualizing and Quantifying Drug Distribution in Tissue III.

We recently proposed a method for selective visualization of topical drug distribution within human facial skin using two-photon fluorescence lifetime imaging along with non-Euclidean phasor analysis as a pharmacokinetics and pharmacodynamics imaging

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ca80dab43d01a9db16d0bfe063045d74
https://doi.org/10.1117/12.2510218

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Characterizing stratum corneum structure, barrier function, and chemical content of human skin with coherent Raman scattering imaging

Autor: Sam Osseiran, Hequn Wang, Christina G. Fthenakis, Sinyoung Jeong, Jomer Dela Cruz, Conor L. Evans

The most superficial layer of the epidermis, the stratum corneum, plays a crucial role in retaining hydration; if its structure or composition is compromised, dry skin may result as a consequence of poor water retention. Dry skin is typically treated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c4eeb7c3bd34347733700b339418d69
https://europepmc.org/articles/PMC6490993/

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Fluorescence lifetime imaging microscopy (FLIM) for visualization of targeted drug delivery and local distribution in skin of a single daily dose of topical minocycline gel: an update on translational research from preclinical to clinical (Conference Presentation)

Autor: Xin Chen, Sinyoung Jeong, Akira Yamamoto, Maiko Hermsmeier, AnnaMarie Daniels, Sam Osseiran, Conor L. Evans, Kin F. Chan, Usha Nagavarapu

Publikováno v: Photonics in Dermatology and Plastic Surgery 2018.

Oral minocycline has been the standard of care for the treatment of non-nodular moderate to severe inflammatory acne vulgaris due to its inhibitory effects on the acne-causing Propionibacterium acnes bacterium and its anti-inflammatory properties, De

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd1274d9773a2f19f89e3faaff6fb797
https://doi.org/10.1117/12.2294084

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Phasor approach to fluorescence lifetime imaging microscopy for visualization and quantification of drug distribution of a topical minocycline gel in human facial skin (Conference Presentation)

Autor: Akira Yamamoto, Maiko Hermsmeier, Usha Nagavarapu, Conor L. Evans, Sam Osseiran, Kin F. Chan, Sinyoung Jeong

Publikováno v: Visualizing and Quantifying Drug Distribution in Tissue II.

Acne vulgaris is a common chronic skin disease in teenagers and young adults. Minocycline, an antibiotic, has thus far been widely utilized to treat acne, but only via oral administration. Recently, a topical minocycline gel (BPX-01) was developed to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0eecde4c6f86b386c62093778f9825a3
https://doi.org/10.1117/12.2290898

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A non-Euclidean phasor approach for distinction of fluorescent compounds using two-photon fluorescence lifetime imaging microscopy in ex vivo human skin (Conference Presentation)

Autor: Yusuke Suita, Elisabeth Roider, Michael C. Murphy, Sam Osseiran, Conor L. Evans, Hequn Wang, David E. Fisher

Publikováno v: Multiphoton Microscopy in the Biomedical Sciences XVIII.

Two-photon fluorescence lifetime imaging microscopy (FLIM) is a technique that not only probes the intensity of fluorophores, but also provides the temporal decay trace of said fluorophores on a pixel-by-pixel basis. These traces can then be transfor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e892ab4c5d544012f280aa8dac9fc634
https://doi.org/10.1117/12.2291211

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