A comparative transcriptomic analysis of replicating and dormant liver stages of the relapsing malaria parasite Plasmodium cynomolgi

Autor: Annemarie Voorberg-van der Wel, Guglielmo Roma, Devendra Kumar Gupta, Sven Schuierer, Florian Nigsch, Walter Carbone, Anne-Marie Zeeman, Boon Heng Lee, Sam O Hofman, Bart W Faber, Judith Knehr, Erica Pasini, Bernd Kinzel, Pablo Bifani, Ghislain M C Bonamy, Tewis Bouwmeester, Clemens H M Kocken, Thierry Tidiane Diagana

Publikováno v: eLife, Vol 6 (2017)

Plasmodium liver hypnozoites, which cause disease relapse, are widely considered to be the last barrier towards malaria eradication. The biology of this quiescent form of the parasite is poorly understood which hinders drug discovery. We report a com

Externí odkaz: https://doaj.org/article/fe01f6ed27ac49e38c3c509c4167af68

Sterile protection against relapsing malaria with a single-shot vaccine

Autor: Erica M. Pasini, Annemarie Voorberg van der Wel, Nicole Heijmans, Onny Klop, Anne-Marie Zeeman, Herman Oostermeijer, Ivonne Nieuwenhuis, Roberto Rodriguez Garcia, Nicole Onur van der Werff, Sam O. Hofman, Frank A. W. Verreck, Edmond J. Remarque, Bart W. Faber, Clemens H. M. Kocken

Publikováno v: npj Vaccines. 7

Vaccine development for Plasmodium vivax, an important human relapsing malaria, is lagging behind. In the case of the most deadly human malaria P. falciparum, unprecedented high levels of protection have been obtained by immunization with live sporoz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c7c3e3794d2879db5fea0b6b11c520a
https://doi.org/10.1038/s41541-022-00555-0

Evaluation of heterologous prime-boost vaccination strategies using chimpanzee adenovirus and modified vaccinia virus for TB subunit vaccination in rhesus macaques

Autor: Krista G. Haanstra, Chantal Hoffmann, Aurelio Bonavia, Patricia A. Darrah, Stéphane Leung-Theung-Long, H. Jacob Borish, Dominick Laddy, Robert A. Seder, Danilo R. Casimiro, Frank A. W. Verreck, Claudia C. Sombroek, Charelle Boot, Nathalie Silvestre, Mary Limbach, Geneviève Inchauspé, Richard A. W. Vervenne, Alexander G. White, Karin Dijkman, Mohamed A Khayum, Michel P.M. Vierboom, Doris Schmitt, Marieke A. Stammes, Maria Lempicki, Nadia Ouaked, Ravi Anantha, Sam O. Hofman, Agnes L Chenine, Thomas G. Evans

Publikováno v: NPJ Vaccines
npj Vaccines, Vol 5, Iss 1, Pp 1-12 (2020)

Tuberculosis (TB) still is the principal cause of death from infectious disease and improved vaccination strategies are required to reduce the disease burden and break TB transmission. Here, we investigated different routes of administration of vecto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84b2a93ee3e47f724bb957e2d68bd132
https://pubmed.ncbi.nlm.nih.gov/32435513

Involvement of the Red Nucleus in the Compensation of Parkinsonism may Explain why Primates can develop Stable Parkinson’s Disease

Autor: Jan A.M. Langermans, Sam O. Hofman, Ingrid H.C.H.M. Philippens, Sigrid K. Franke, Jacqueline Wubben

Publikováno v: Scientific Reports, 9:880, 1-9. Nature Publishing Group
Scientific Reports
Scientific Reports, 9(1). NLM (Medline)
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Philippens, I H C H M, Wubben, J A, Franke, S K, Hofman, S & Langermans, J A M 2019, ' Involvement of the Red Nucleus in the Compensation of Parkinsonism may Explain why Primates can develop Stable Parkinson’s Disease ', Scientific Reports, vol. 9, 880, pp. 1-9 . https://doi.org/10.1038/s41598-018-37381-1

Neurological compensatory mechanisms help our brain to adjust to neurodegeneration as in Parkinson’s disease. It is suggested that the compensation of the damaged striato-thalamo-cortical circuit is focused on the intact thalamo-rubro-cerebellar pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae090b2248635460ea4d302005f1399c
https://research.vu.nl/en/publications/1ece4d82-5f1b-4609-8fd6-35bfdddf40f8

Individual and Familial Susceptibility to MPTP in a Common Marmoset Model for Parkinson's Disease

Autor: August B. Smit, Sam O. Hofman, Ronald E. van Kesteren, Sigrid K. Franke, Jacqueline Wubben, Ingrid H.C.H.M. Philippens

Publikováno v: van Kesteren, R E, Hofman, S, Wubben, J A M, Smit, A B & Philippens, I H C H M 2016, ' Individual and Familial Susceptibility to MPTP in a Common Marmoset Model for Parkinson's Disease ', Neurodegenerative Diseases, vol. 16, no. 5-6, pp. 293-303 . https://doi.org/10.1159/000442574
Neurodegenerative Diseases, 16(5-6), 293-303. S. Karger AG

Introduction: Insight into susceptibility mechanisms underlying Parkinson's disease (PD) would aid the understanding of disease etiology, enable target finding and benefit the development of more refined disease-modifying strategies. Methods: We used

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a1cf0e693d00d416092a73f222888f1
https://doi.org/10.1159/000442574