Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Sam Mulders"'
Autor:
Annemieke Aartsma-Rus, Gjb van Ommen, Sam Mulders, J.T. den Dunnen, Melvin M. Evers, Hoang-Dai Tran, Wmc van Roon-Mom, Jct van Deutekom
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 83:A52.1-A52
There has been a recent surge in research using antisense oligonucleotides (AONs) to reduce huntingtin transcript levels and thus huntingtin protein levels both in vitro an in vivo. This can be done in a non-allele specific manner by targeting both m
Autor:
Jct van Deutekom, J van de Giessen, Sam Mulders, A Jahanshahianvar, Yasin Temel, Rinske Vlamings
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 83:A52.2-A52
Background Huntington9s disease (HD) is caused by an expanded (CAG)n tract in the Huntingtin gene ( HTT) that is translated into an expanded polyglutamine (polyQ) stretch in the protein. The polyQ stretch causes a toxic gain of function and plays a c
Autor:
González-Barriga, Anchel, Nillessen, Bram, Kranzen, Julia, van Kessel, Ingeborg D.G., Croes, Huib J.E., Aguilera, Begoña, de Visser, Peter C., Datson, Nicole A., Mulders, Susan A.M., van Deutekom, Judith C.T., Wieringa, Bé, Wansink, Derick G.
Publikováno v:
Nucleic Acid Therapeutics; Jun2017, Vol. 27 Issue 3, p144-158, 15p