Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Sam Mesiano"'
Autor:
Nollaig M. Bourke, Sharon L. Achilles, Stephanie U-Shane Huang, Helen E. Cumming, San S. Lim, Irene Papageorgiou, Linden J. Gearing, Ross Chapman, Suruchi Thakore, Niamh E. Mangan, Sam Mesiano, Paul J. Hertzog
Publikováno v:
JCI Insight, Vol 7, Iss 18 (2022)
Although published studies have demonstrated that IFN-ε has a crucial role in regulating protective immunity in the mouse female reproductive tract, expression and regulation of IFN-ε in the human female reproductive tract (hFRT) have not been char
Externí odkaz:
https://doaj.org/article/617002a4f4874767b54742108c6286e8
Autor:
Chong Qiao, Ramkumar Menon, Ki Hoon Ahn, Shunji Suzuki, Pallavi Kshetrapal, Harry Michael Georgiou, Sam Mesiano, Nanbert Zhong
Publikováno v:
Frontiers in Pediatrics, Vol 10 (2022)
Preterm birth (PTB) is one of the most important problems that pose dilemmas for both the obstetrician and neonatologist, placing a heavy burden psychologically and financially on the families involved, and triggering high socio-economic costs to the
Externí odkaz:
https://doaj.org/article/3a61dea7cd6b49af81877c3728cc511f
Autor:
Ashley L. Severance, Jeremy M. Kinder, Lijun Xin, Ashley R. Burg, Tzu-Yu Shao, Giang Pham, Tamara Tilburgs, Wendy A. Goodman, Sam Mesiano, Sing Sing Way
Publikováno v:
iScience, Vol 25, Iss 6, Pp 104400- (2022)
Summary: Pregnancy stimulates an intricately coordinated assortment of physiological changes to accommodate growth of the developing fetus, while simultaneously averting rejection of genetically foreign fetal cells and tissues. Despite increasing evi
Externí odkaz:
https://doaj.org/article/7b95a0586b3243009339a6e36f9ae471
Autor:
Pei F. Lai, Kaiyu Lei, Xiaoyu Zhan, Gavin Sooranna, Jonathan K. H. Li, Ektoras X. Georgiou, Ananya Das, Natasha Singh, Qiye Li, Zachary Stanfield, Guojie Zhang, Rachel M. Tribe, Sam Mesiano, Mark R. Johnson
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
High throughput sequencing has previously identified differentially expressed genes (DEGs) and enriched signalling networks in human myometrium for term (≥37 weeks) gestation labour, when defined as a singular state of activity at comparison to the
Externí odkaz:
https://doaj.org/article/679dd01ccbe94cde95427de4260db516
Publikováno v:
eLife, Vol 9 (2020)
Eutherian mammals have characteristic lengths of gestation that are key for reproductive success, but relatively little is known about the processes that determine the timing of parturition, the process of birth, and how they are coordinated with fet
Externí odkaz:
https://doaj.org/article/be11f3de411e43069e7bf424ab07bbf7
Autor:
Zachary Stanfield, Pei F. Lai, Kaiyu Lei, Mark R. Johnson, Andrew M. Blanks, Roberto Romero, Mark R. Chance, Sam Mesiano, Mehmet Koyutürk
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Externí odkaz:
https://doaj.org/article/e51519a3ab1c4a94b3e132e42e83f75f
Autor:
Zachary Stanfield, Pei F. Lai, Kaiyu Lei, Mark R. Johnson, Andrew M. Blanks, Roberto Romero, Mark R. Chance, Sam Mesiano, Mehmet Koyutürk
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
The process of parturition involves the transformation of the quiescent myometrium (uterine smooth muscle) to the highly contractile laboring state. This is thought to be driven by changes in gene expression in myometrial cells. Despite the existence
Externí odkaz:
https://doaj.org/article/6960c99feb5d480eb5df38c97f07e6b8
Autor:
Lubna Nadeem, Oksana Shynlova, Elzbieta Matysiak-Zablocki, Sam Mesiano, Xuesen Dong, Stephen Lye
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
How human labour is initiated in the presence of high circulating progesterone is still unclear. Here, the authors show that during a reduction in myometrial nuclear progesterone levels, there is an increased transcription of the key labour gene, Cx4
Externí odkaz:
https://doaj.org/article/a9cbb860df8546a38946568c449db560
Publikováno v:
Frontiers in Endocrinology, Vol 8 (2017)
Human parturition is an inflammatory process that involves both fetal and maternal compartments. The precise immune cell interactions have not been well delineated in human uterine tissues during parturition, but insights into human labor initiation
Externí odkaz:
https://doaj.org/article/2ed83c55fc11408a80177a4c9ceaf5c1
Autor:
Andrew M Bisits, Roger Smith, Sam Mesiano, George Yeo, Kenneth Kwek, David MacIntyre, Eng C Chan
Publikováno v:
PLoS Computational Biology, Vol 1, Iss 2, Pp 132-136 (2005)
There are three main hypotheses for the activation of the human uterus at labour: functional progesterone withdrawal, inflammatory stimulation, and oxytocin receptor activation. To test these alternatives we have taken information and data from the l
Externí odkaz:
https://doaj.org/article/bbe97720309b4764ad1ff63db63846cd