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Akademický článek

Antenatal dexamethasone after asphyxia increases neural injury in preterm fetal sheep.

Autor: Miriam E Koome, Joanne O Davidson, Paul P Drury, Sam Mathai, Lindsea C Booth, Alistair Jan Gunn, Laura Bennet

Publikováno v: PLoS ONE, Vol 8, Iss 10, p e77480 (2013)

BACKGROUND AND PURPOSE: Maternal glucocorticoid treatment for threatened premature delivery dramatically improves neonatal survival and short-term morbidity; however, its effects on neurodevelopmental outcome are variable. We investigated the effect

Externí odkaz: https://doaj.org/article/3880844cd506416493237e7dbb56d9cd

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Protective effects of delayed intraventricular TLR7 agonist administration on cerebral white and gray matter following asphyxia in the preterm fetal sheep

Autor: Kenta H T Cho, Mhoyra Fraser, Luke Weaver-Mikaere, Joanne O. Davidson, Simerdeep K Dhillon, Lotte G. van den Heuij, Laura Bennet, Guido Wassink, Alistair J. Gunn, Bing Xu, Sam Mathai, Robert Galinsky

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
Scientific Reports

Preterm brain injury is highly associated with inflammation, which is likely related in part to sterile responses to hypoxia-ischemia. We have recently shown that neuroprotection with inflammatory pre-conditioning in the immature brain is associated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dfda8e7bedbde97a444d9278af0b23f
http://link.springer.com/article/10.1038/s41598-019-45872-y

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Lipopolysaccharide-Induced Preconditioning Attenuates Apoptosis and Differentially Regulates TLR4 and TLR7 Gene Expression after Ischemia in the Preterm Ovine Fetal Brain

Autor: Yewon Jung, Sam Mathai, Alistair J. Gunn, Laura Bennet, Mhoyra Fraser, Simerdeep K Dhillon

Publikováno v: Developmental Neuroscience. 37:497-514

Acute exposure to subclinical infection modulates subsequent hypoxia-ischemia (HI) injury in a time-dependent manner, likely by cross-talk through Toll-like receptors (TLRs), but the specific pathways are unclear in the preterm-equivalent brain. In t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5226ccbb1fc80a1d155f3d3d3ce4c95f
https://doi.org/10.1159/000433422

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Window of Opportunity for Neuroprotection with an Antioxidant, Allene Oxide Synthase, after Hypoxia-Ischemia in Adult Male Rats

Autor: Sam Mathai, Alistair J. Gunn, Ralph Andrew Backhaus, Jian Guan

Publikováno v: CNS Neuroscience & Therapeutics. 18:887-894

Summary Aims Oxidative stress is an early event in the cascade leading in neuronal damage after hypoxic–ischemic (HI) brain injury. In the present study, we examined the dose response and window of opportunity for neuroprotection after HI injury wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a44c08c5a1ff9eea69d1a930fdf34ad7
https://doi.org/10.1111/cns.12004

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Limited predictive value of early changes in EEG spectral power for neural injury after asphyxia in preterm fetal sheep

Autor: Michael J. Keogh, Eleanor R. Gunn, Paul P. Drury, Lindsea C. Booth, Alistair J. Gunn, Sam Mathai, Joanne O. Davidson, Laura Bennet

Publikováno v: Pediatric Research. 71:345-353

This study examined whether spectral analysis of the electroencephalogram (EEG) can discriminate between mild and severe hypoxic-ischemic injury in the immature brain.Total EEG power was profoundly suppressed after umbilical cord occlusion and recove

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb470396af8bb7ccfbe3b4261c6e6f78
https://doi.org/10.1038/pr.2011.80

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Peripheral administration of a novel diketopiperazine, NNZ 2591, prevents brain injury and improves somatosensory-motor function following hypoxia–ischemia in adult rats

Autor: Margaret A. Brimble, Sam Mathai, Jingyuan Wen, Jian Guan, Rong Zhang, Peter D. Gluckman, Paul W. R. Harris

Publikováno v: Neuropharmacology. 53:749-762

The current study describes the neuroprotective effects of an endogenous diketopiperazine, cyclo-glycyl-proline (cyclic GP), in rats with hypoxic-ischemic brain injury and the pre-clinical development of an analogue, cyclo-L-glycyl-L-2-allylproline (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e16beec33c7523577e26d5aa09bf7e
https://doi.org/10.1016/j.neuropharm.2007.08.010

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Neuroprotective effects of the N-terminal tripeptide of insulin-like growth factor-1, glycine-proline-glutamate (GPE) following intravenous infusion in hypoxic–ischemic adult rats

Autor: Sam Mathai, H Lin, D.C. Bachelor, Jian Guan, Peter D. Gluckman, S. George, G.B. Thomas

Publikováno v: Neuropharmacology. 47:892-903

The N-terminal tripeptide of insulin-like growth factor-1, GPE is neuroprotective when given intracerebroventricularly 2 h after hypoxic-ischemic (HI) brain injury in rats. We have now examined whether GPE can cross the blood-brain barrier and exert

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90526aa111dac8362789b0125b5811e0
https://doi.org/10.1016/j.neuropharm.2004.07.002

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Synergistic white matter protection with acute-on-chronic endotoxin and subsequent asphyxia in preterm fetal sheep

Autor: Lindsea C. Booth, Alistair J. Gunn, Christopher A. Lear, Mhoyra Fraser, Sam Mathai, Joanne O. Davidson, Lotte G. van den Heuij, Laura Bennet

Publikováno v: Journal of Neuroinflammation

Background Perinatal asphyxia and exposure to intrauterine infection are associated with impaired neurodevelopment in preterm infants. Acute exposure to non-injurious infection and/or inflammation can either protect or sensitize the brain to subseque

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4d9a0a532e4a32a4e63e430609a5b50
https://doi.org/10.1186/1742-2094-11-89

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nNOS inhibition during profound asphyxia reduces seizure burden and improves survival of striatal phenotypic neurons in preterm fetal sheep

Autor: Sam Mathai, Alistair J. Gunn, Sidhartha Tan, Richard B. Silverman, Paul P. Drury, Haitao Ji, Lotte G. van den Heuij, Laura Bennet, Joanne O. Davidson

Basal ganglia injury after hypoxia-ischemia remains common in preterm infants, and is closely associated with later cerebral palsy. In the present study we tested the hypothesis that a highly selective neuronal nitric oxide synthase (nNOS) inhibitor,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::253fb15ed82ea26b271f1308f82d53ff
https://europepmc.org/articles/PMC4077724/

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