Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Sam Massa"'
Autor:
Quentin Lecocq, Katty Zeven, Yannick De Vlaeminck, Sandrina Martens, Sam Massa, Cleo Goyvaerts, Geert Raes, Marleen Keyaerts, Karine Breckpot, Nick Devoogdt
Publikováno v:
Biomolecules, Vol 9, Iss 10, p 548 (2019)
Immune checkpoint inhibition (ICI) is a promising cancer therapy, which has progressed rapidly from a preclinical concept to clinical implementation. Commonly considered targets in ICI are CTLA-4, PD-1/PD-L1, and LAG-3, and the list grows. As ICI is
Externí odkaz:
https://doaj.org/article/2cad000699384e4e8bdccf532a675f49
Autor:
Nick Devoogdt, Tony Lahoutte, Michael R. Zalutsky, Vicky Caveliers, Geert Raes, Sam Massa, Yann G.J. Sterckx, Marek Pruszynski, Catarina Xavier, Jens De Vos, Matthias D'Huyvetter
Supplementary Table S5 shows the ex vivo biodistribution of 131I-2Rs15d after 1h in mice with BT474/M1 xenografts that were pre-treated 72h earlier with a 100-fold molar excess of trastuzumab, pertuzumab or a combination of both.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2734222273f7d0ee6abe43e986834f4
https://doi.org/10.1158/1078-0432.22468586.v1
https://doi.org/10.1158/1078-0432.22468586.v1
Autor:
Nick Devoogdt, Tony Lahoutte, Michael R. Zalutsky, Vicky Caveliers, Geert Raes, Sam Massa, Yann G.J. Sterckx, Marek Pruszynski, Catarina Xavier, Jens De Vos, Matthias D'Huyvetter
Purpose: Camelid single-domain antibody-fragments (sdAb) have beneficial pharmacokinetic properties, and those targeted to HER2 can be used for imaging of HER2-overexpressing cancer. Labeled with a therapeutic radionuclide, they may be used for HER2-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0df94826128d37a28124562b009a8d4e
https://doi.org/10.1158/1078-0432.c.6527000.v1
https://doi.org/10.1158/1078-0432.c.6527000.v1
Autor:
Nick Devoogdt, Tony Lahoutte, Michael R. Zalutsky, Vicky Caveliers, Geert Raes, Sam Massa, Yann G.J. Sterckx, Marek Pruszynski, Catarina Xavier, Jens De Vos, Matthias D'Huyvetter
A detailed description of the materials and methods used for the HER2-2Rs15d structure determination, the radioiodination of sdAbs, and all flow cytometry experiments.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1fb4552e292abbaed6e7e922ede3c0b
https://doi.org/10.1158/1078-0432.22468601.v1
https://doi.org/10.1158/1078-0432.22468601.v1
Autor:
Nick Devoogdt, Tony Lahoutte, Michael R. Zalutsky, Vicky Caveliers, Geert Raes, Sam Massa, Yann G.J. Sterckx, Marek Pruszynski, Catarina Xavier, Jens De Vos, Matthias D'Huyvetter
Supplementary figure S1 details the HER2-epitope recognized by 2Rs15d compared to those reported for other described HER2-binders and a view of HER2-ÂÃ,â2Rs15d interactions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b2c09a3063a53f6722e54527b5aa027
https://doi.org/10.1158/1078-0432.22468583.v1
https://doi.org/10.1158/1078-0432.22468583.v1
Autor:
Catarina Xavier, Yann G.-J. Sterckx, Michael R. Zalutsky, Geert Raes, Vicky Caveliers, Sam Massa, Marek Pruszynski, Nick Devoogdt, Tony Lahoutte, Matthias D'Huyvetter, Jens De Vos
Publikováno v:
Clinical Cancer Research. 23:6616-6628
Purpose: Camelid single-domain antibody-fragments (sdAb) have beneficial pharmacokinetic properties, and those targeted to HER2 can be used for imaging of HER2-overexpressing cancer. Labeled with a therapeutic radionuclide, they may be used for HER2-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09371574e9840eee5a3f88303a94ec57
https://doi.org/10.1158/1078-0432.ccr-17-0310
https://doi.org/10.1158/1078-0432.ccr-17-0310
Autor:
Hilde Jans, Tim Stakenborg, Serge Muyldermans, Charlotte Verstraete, Antoine D'Hollander, Liesbet Lagae, Sam Massa, Greetje Vande Velde, Uwe Himmelreich, Nick Devoogdt
Publikováno v:
Biomaterials. 123:15-23
Gold nanoparticles hold great promise as anti-cancer theranostic agents against cancer by actively targeting the tumor cells. As this potential has been supported numerously during in vitro experiments, the effective application is hampered by our li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::164054fc5417c183962c5c03b0fb68cd
https://doi.org/10.1016/j.biomaterials.2017.01.007
https://doi.org/10.1016/j.biomaterials.2017.01.007
Autor:
Robert Alvin Bernedo-Navarro, Sam Massa, Serge Muyldermans, Sadegh Hassania, Khosro Khajeh, Golnaz Sadeghnezhad, Ema Romão
Publikováno v:
International Journal of Molecular Sciences
Volume 20
Issue 19
International Journal of Molecular Sciences, Vol 20, Iss 19, p 4818 (2019)
Volume 20
Issue 19
International Journal of Molecular Sciences, Vol 20, Iss 19, p 4818 (2019)
Current cancer therapeutics suffer from a lack of specificity in targeting tumor cells and cause severe side effects. Therefore, the design of highly specialized drugs comprising antibody derivatives inducing apoptosis in targeted cancer cells is con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f423afd619e4b60be6b2d470fa07a3e6
Autor:
Nick Devoogdt, Sandrina Martens, Marleen Keyaerts, Sam Massa, Yannick De Vlaeminck, Karine Breckpot, Katty Zeven, Cleo Goyvaerts, Geert Raes, Quentin Lecocq
Publikováno v:
Biomolecules, Vol 9, Iss 10, p 548 (2019)
Biomolecules
Volume 9
Issue 10
Biomolecules
Volume 9
Issue 10
Immune checkpoint inhibition (ICI) is a promising cancer therapy, which has progressed rapidly from a preclinical concept to clinical implementation. Commonly considered targets in ICI are CTLA-4, PD-1/PD-L1, and LAG-3, and the list grows. As ICI is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c931ad1f7671a1bebb10f62f89270d23
https://www.mdpi.com/2218-273X/9/10/548
https://www.mdpi.com/2218-273X/9/10/548
Autor:
Catarina Xavier, Serge Muyldermans, Anton Bunschoten, Sophie Hernot, Sam Massa, Christian Vanhove, Vicky Caveliers, Steven Ballet, Benedicte Descamps, Nick Devoogdt, Fijs W. B. van Leeuwen, Tony Lahoutte, Jan Steyaert, Saskia Vanderhaegen, Niravkumar Arvindbhai Vikani, Cecilia Betti
Publikováno v:
Contrast Media & Molecular Imaging. 11:328-339
A generic site-specific conjugation method that generates a homogeneous product is of utmost importance in tracer development for molecular imaging and therapy. We explored the protein-ligation capacity of the enzyme Sortase A to label camelid single
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea955e90ceab1824ba1dfe1efa53f24c
https://doi.org/10.1002/cmmi.1696
https://doi.org/10.1002/cmmi.1696